ID   AC23_NPVAC              Reviewed;         690 AA.
AC   P41428;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Protein AC23;
DE   AltName: Full=ORF 9;
DE   Flags: Precursor;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=E2;
RX   PubMed=1333113; DOI=10.1016/0042-6822(92)90281-s;
RA   Braunagel S.C., Daniel K.D., Reilly L.M., Guarino L.A., Hong T.,
RA   Summers M.D.;
RT   "Sequence, genomic organization of the EcoRI-A fragment of Autographa
RT   californica nuclear polyhedrosis virus, and identification of a viral-
RT   encoded protein resembling the outer capsid protein VP8 of rotavirus.";
RL   Virology 191:1003-1008(1992).
RN   [3]
RP   SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=12477838; DOI=10.1128/jvi.77.1.328-339.2003;
RA   Lung O.Y., Cruz-Alvarez M., Blissard G.W.;
RT   "Ac23, an envelope fusion protein homolog in the baculovirus Autographa
RT   californica multicapsid nucleopolyhedrovirus, is a viral pathogenicity
RT   factor.";
RL   J. Virol. 77:328-339(2003).
RN   [4]
RP   FUNCTION.
RX   PubMed=18653446; DOI=10.1128/jvi.00759-08;
RA   Wang M., Tan Y., Yin F., Deng F., Vlak J.M., Hu Z., Wang H.;
RT   "The F-like protein Ac23 enhances the infectivity of the budded virus of
RT   gp64-null Autographa californica multinucleocapsid nucleopolyhedrovirus
RT   pseudotyped with baculovirus envelope fusion protein F.";
RL   J. Virol. 82:9800-9804(2008).
CC   -!- FUNCTION: Pathogenicity factor that accelerates mortality in the host
CC       insect. {ECO:0000269|PubMed:12477838, ECO:0000269|PubMed:18653446}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:12477838}.
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DR   EMBL; L22858; AAA66653.1; -; Genomic_DNA.
DR   EMBL; M96361; AAA66793.1; -; Genomic_DNA.
DR   PIR; G72852; G72852.
DR   RefSeq; NP_054052.1; NC_001623.1.
DR   PRIDE; P41428; -.
DR   GeneID; 1403855; -.
DR   KEGG; vg:1403855; -.
DR   Proteomes; UP000008292; Genome.
DR   InterPro; IPR022048; Envelope_fusion-like.
DR   Pfam; PF12259; Baculo_F; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal; Virion.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000255"
FT   CHAIN           38..690
FT                   /note="Protein AC23"
FT                   /id="PRO_0000036749"
SQ   SEQUENCE   690 AA;  79857 MW;  05686E4088DCAA2C CRC64;
     MLACKFSQYQ AFIMDGVKLL GTCALIILLS TTSTVVGRDR ITFTPIEDSA GLMFERMYGL
     RHHTDDRFVF VKKFNFVSVL QELNNIKSKI ELYEAQVSTC TNVRQIKQNR SSIIKARIEN
     QLQFLTQLNK NLITYSVESS ILSNDVLDNI DLEYDDSGEF DVYDEYEQPS HWSNMTVSDA
     QALLRNPPKD RVMFLDTVTT SDVSSKYEEY INCIVSNRTV ENECMFLANM MNVLNDKLDD
     AAALAKMLER IVKQTRKNKL NISNTVIDDD TLLTEMKKLT QTLYNQNRVW VVDFNKDMNS
     YFDLSQAYKL HLYVDLNTVI MFITMPLLKS TAVSFNLYRV MTVPFCRGKM CLLIISGNEY
     FGITDSKNYY VPVSDNFRQD CQEFTGYNEF LCPETEPIAT MNSKVCEIEM FMGRYSDDVD
     NMCDIRVANY NPKKAYVNTL IDYRKWLYIF PNTTVSVHYY CHDALVEVDT KVSPGVGVMF
     STMAQTCSIR ITYDVTITVD SRFYVSHSTT YWPKKKFNFN NYIDQMLLEK ATTSFIPTVD
     NFTRPVLLQL PHKFHIKDYT STPHHFFHQS KIYTNSAAPD EDSQDDSNTT VVIIAIVAAM
     ILFCGLLLFL FCCIKKRCHQ SNNVVVQYKN NNEFVTICNN LEDNRAYINL PNEYDSDDMP
     KPLYPLLGFN DDLLKDDKPV LYPMIIERIK