ID   TBA_BLEJA               Reviewed;          50 AA.
AC   Q08628;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Tubulin alpha chain;
DE   Flags: Fragment;
OS   Blepharisma japonicum.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Postciliodesmatophora;
OC   Heterotrichea; Heterotrichida; Blepharismidae; Blepharisma.
OX   NCBI_TaxID=5961;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7685500; DOI=10.1007/bf01175738;
RA   Liang A., Heckmann K.;
RT   "Blepharisma uses UAA as a termination codon.";
RL   Naturwissenschaften 80:225-226(1993).
CC   -!- FUNCTION: Tubulin is the major constituent of microtubules. It binds
CC       two moles of GTP, one at an exchangeable site on the beta chain and one
CC       at a non-exchangeable site on the alpha chain.
CC   -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC       hollow water-filled tube with an outer diameter of 25 nm and an inner
CC       diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC       form protofilaments running lengthwise along the microtubule wall with
CC       the beta-tubulin subunit facing the microtubule plus end conferring a
CC       structural polarity. Microtubules usually have 13 protofilaments but
CC       different protofilament numbers can be found in some organisms and
CC       specialized cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR   EMBL; S62518; AAB27144.1; -; mRNA.
DR   PIR; S36687; S36687.
DR   AlphaFoldDB; Q08628; -.
DR   SMR; Q08628; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   Gene3D; 1.10.287.600; -; 1.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR023123; Tubulin_C.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   SUPFAM; SSF55307; SSF55307; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding.
FT   CHAIN           <1..50
FT                   /note="Tubulin alpha chain"
FT                   /id="PRO_0000048142"
FT   NON_TER         1
SQ   SEQUENCE   50 AA;  5659 MW;  3749548FCEA9E3F9 CRC64;
     FVHWYVGEGM EEGEFSEARE DLAALEKDYE EVGIETAEAE GEEEGYGEEL