ID   TBA_ENCCU               Reviewed;         441 AA.
AC   Q8SRI6;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Tubulin alpha chain;
GN   Name=TUB1; OrderedLocusNames=ECU07_1190;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- FUNCTION: Tubulin is the major constituent of microtubules. It binds
CC       two moles of GTP, one at an exchangeable site on the beta chain and one
CC       at a non-exchangeable site on the alpha chain.
CC   -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC       hollow water-filled tube with an outer diameter of 25 nm and an inner
CC       diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC       form protofilaments running lengthwise along the microtubule wall with
CC       the beta-tubulin subunit facing the microtubule plus end conferring a
CC       structural polarity. Microtubules usually have 13 protofilaments but
CC       different protofilament numbers can be found in some organisms and
CC       specialized cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR   EMBL; AL590447; CAD25652.1; -; Genomic_DNA.
DR   RefSeq; NP_586048.1; NM_001041670.1.
DR   AlphaFoldDB; Q8SRI6; -.
DR   SMR; Q8SRI6; -.
DR   STRING; 284813.Q8SRI6; -.
DR   PRIDE; Q8SRI6; -.
DR   GeneID; 859478; -.
DR   KEGG; ecu:ECU07_1190; -.
DR   VEuPathDB; MicrosporidiaDB:ECU07_1190; -.
DR   HOGENOM; CLU_015718_0_0_1; -.
DR   InParanoid; Q8SRI6; -.
DR   OMA; KVGICYQ; -.
DR   OrthoDB; 514396at2759; -.
DR   Proteomes; UP000000819; Chromosome VII.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   Gene3D; 1.10.287.600; -; 1.
DR   Gene3D; 3.30.1330.20; -; 1.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR002452; Alpha_tubulin.
DR   InterPro; IPR013838; Beta-tubulin_BS.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR   InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR023123; Tubulin_C.
DR   InterPro; IPR017975; Tubulin_CS.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   Pfam; PF03953; Tubulin_C; 1.
DR   PRINTS; PR01162; ALPHATUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SMART; SM00864; Tubulin; 1.
DR   SMART; SM00865; Tubulin_C; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
DR   SUPFAM; SSF55307; SSF55307; 1.
DR   PROSITE; PS00227; TUBULIN; 1.
DR   PROSITE; PS00228; TUBULIN_B_AUTOREG; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..441
FT                   /note="Tubulin alpha chain"
FT                   /id="PRO_0000048167"
FT   BINDING         139..145
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   SITE            441
FT                   /note="Involved in polymerization"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   441 AA;  49315 MW;  1195C73B376A6856 CRC64;
     MREIISLHIG QAGVQIGNAC WELYCKEHGI LPNGQLDQNK MDDESAESFF SPTSVGTYVP
     RTLMVDLEPG VLDSIKTGKY RELYHPGQLI SGKEDAANNY ARGHYTVGKE IIEPAMEQIR
     RMADSCDGLQ GFLIYHSFGG GTGSGFASLM MDRLAAEFGK KSKLEFSVYP APKIATAVVE
     PYNSILTTHT TLDYSDCSFL VDNEAIYDMC RNLGIQRPYY TDINRVIAQV VSSITASLRF
     PGSLNVDLTE FQTNLVPYPR IHFPLVAYSP MLSKEKAAHE KLSVQEITNA CFEPQNQMVR
     CDTRKGKYMA CCLLFRGDVN PKEANNATAN VKAKRTNQFV EWCPTGFKVG INSRKPTVLD
     GEAMAEVSRA VCALSNTTAI SEAWKRLNNK FDLMFSKRAF VHWYVGEGME EGEFSEARED
     LAMLEDDYER ISSNAEPVDE Y