ID   TBA_PICAB               Reviewed;         113 AA.
AC   P33628;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Tubulin alpha chain;
DE   Flags: Fragment;
GN   Name=TUBA;
OS   Picea abies (Norway spruce) (Picea excelsa).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Pinopsida; Pinidae; Conifers I; Pinales; Pinaceae; Picea.
OX   NCBI_TaxID=3329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1373081; DOI=10.1007/bf00020013;
RA   Sundaas A., Tandre K., Holmstedt E., Engstroem P.;
RT   "Differential gene expression during germination and after the induction of
RT   adventitious bud formation in Norway spruce embryos.";
RL   Plant Mol. Biol. 18:713-724(1992).
CC   -!- FUNCTION: Tubulin is the major constituent of microtubules. It binds
CC       two moles of GTP, one at an exchangeable site on the beta chain and one
CC       at a non-exchangeable site on the alpha chain.
CC   -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC       hollow water-filled tube with an outer diameter of 25 nm and an inner
CC       diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC       form protofilaments running lengthwise along the microtubule wall with
CC       the beta-tubulin subunit facing the microtubule plus end conferring a
CC       structural polarity. Microtubules usually have 13 protofilaments but
CC       different protofilament numbers can be found in some organisms and
CC       specialized cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR   EMBL; X57980; CAA41045.1; -; mRNA.
DR   PIR; S20865; S20865.
DR   AlphaFoldDB; P33628; -.
DR   SMR; P33628; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR002452; Alpha_tubulin.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   PRINTS; PR01162; ALPHATUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SUPFAM; SSF52490; SSF52490; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding.
FT   CHAIN           <1..>113
FT                   /note="Tubulin alpha chain"
FT                   /id="PRO_0000048216"
FT   NON_TER         1
FT   NON_TER         113
SQ   SEQUENCE   113 AA;  12573 MW;  5E808FC30CFEB563 CRC64;
     CWELYWLEHG IQPDGMMPSD TTVGVGDDAF NTFFSETGAG KHVPRAVFVD LEPTVIDEVR
     TGAYRQLFHP EQLISGKEDA ANNFARGHYT VGEEIVDLCL DRVRKLADNC TGL