TBB2B_BOVIN
ID TBB2B_BOVIN Reviewed; 445 AA.
AC Q6B856;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Tubulin beta-2B chain;
GN Name=TUBB2B;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hwang K.C., Park S.Y., Cui X.S., Kim N.H.;
RT "Differentially expressed genes in bovine 8-cell embryo.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19390049; DOI=10.1126/science.1169588;
RG The bovine genome sequencing and analysis consortium;
RT "The genome sequence of taurine cattle: a window to ruminant biology and
RT evolution.";
RL Science 324:522-528(2009).
CC -!- FUNCTION: Tubulin is the major constituent of microtubules. It binds
CC two moles of GTP, one at an exchangeable site on the beta chain and one
CC at a non-exchangeable site on the alpha chain. Plays a critical role in
CC proper axon guidance in both central and peripheral axon tracts.
CC Implicated in neuronal migration. {ECO:0000250,
CC ECO:0000250|UniProtKB:Q9BVA1}.
CC -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC hollow water-filled tube with an outer diameter of 25 nm and an inner
CC diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC form protofilaments running lengthwise along the microtubule wall with
CC the beta-tubulin subunit facing the microtubule plus end conferring a
CC structural polarity. Microtubules usually have 13 protofilaments but
CC different protofilament numbers can be found in some organisms and
CC specialized cells. {ECO:0000250|UniProtKB:Q9BVA1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q9BVA1}.
CC -!- DOMAIN: The MREI motif is common among all beta-tubulin isoforms and
CC may be critical for tubulin autoregulation.
CC {ECO:0000250|UniProtKB:P07437}.
CC -!- PTM: Some glutamate residues at the C-terminus are polyglycylated,
CC resulting in polyglycine chains on the gamma-carboxyl group.
CC Glycylation is mainly limited to tubulin incorporated into axonemes
CC (cilia and flagella) whereas glutamylation is prevalent in neuronal
CC cells, centrioles, axonemes, and the mitotic spindle. Both
CC modifications can coexist on the same protein on adjacent residues, and
CC lowering polyglycylation levels increases polyglutamylation, and
CC reciprocally. The precise function of polyglycylation is still unclear.
CC {ECO:0000250|UniProtKB:A2AQ07}.
CC -!- PTM: Some glutamate residues at the C-terminus are polyglutamylated,
CC resulting in polyglutamate chains on the gamma-carboxyl group (By
CC similarity). Polyglutamylation plays a key role in microtubule severing
CC by spastin (SPAST). SPAST preferentially recognizes and acts on
CC microtubules decorated with short polyglutamate tails: severing
CC activity by SPAST increases as the number of glutamates per tubulin
CC rises from one to eight, but decreases beyond this glutamylation
CC threshold (By similarity). {ECO:0000250|UniProtKB:A2AQ07,
CC ECO:0000250|UniProtKB:Q71U36}.
CC -!- PTM: Phosphorylated on Ser-172 by CDK1 during the cell cycle, from
CC metaphase to telophase, but not in interphase. This phosphorylation
CC inhibits tubulin incorporation into microtubules.
CC {ECO:0000250|UniProtKB:Q9BVA1}.
CC -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR EMBL; AY675081; AAT84374.1; -; mRNA.
DR RefSeq; NP_001003900.1; NM_001003900.1.
DR PDB; 1SA0; X-ray; 3.58 A; B/D=1-439.
DR PDB; 1SA1; X-ray; 4.20 A; B/D=1-439.
DR PDB; 1TVK; X-ray; 2.89 A; B=1-427.
DR PDB; 1Z2B; X-ray; 4.10 A; B/D=1-445.
DR PDB; 2P4N; EM; 9.00 A; B=1-445.
DR PDB; 2WBE; EM; 9.40 A; B=1-445.
DR PDB; 2XRP; EM; 8.20 A; A/C/E/G=1-445.
DR PDB; 3DCO; EM; 1.90 A; B=1-445.
DR PDB; 3DU7; X-ray; 4.10 A; B/D=1-445.
DR PDB; 3E22; X-ray; 3.80 A; B/D=1-445.
DR PDB; 3IZ0; EM; 8.60 A; B=1-445.
DR PDB; 3J1T; EM; 9.70 A; C=1-427.
DR PDB; 3J1U; EM; 9.70 A; C=1-427.
DR PDB; 3J2U; EM; 10.80 A; B/D=1-445.
DR PDB; 4AQV; EM; 9.70 A; B=1-445.
DR PDB; 4AQW; EM; 9.50 A; B=1-445.
DR PDB; 4ATU; EM; 8.30 A; A/C/E/G=1-445.
DR PDB; 4ATX; EM; 8.20 A; A=1-445.
DR PDB; 4CK5; EM; 10.00 A; B=1-445.
DR PDB; 4CK6; EM; 9.20 A; B=1-445.
DR PDB; 4CK7; EM; 9.20 A; B=1-445.
DR PDB; 4I4T; X-ray; 1.80 A; B/D=1-445.
DR PDB; 4I50; X-ray; 2.30 A; B/D=1-445.
DR PDB; 4I55; X-ray; 2.20 A; B/D=1-445.
DR PDB; 4IHJ; X-ray; 2.00 A; B/D=1-445.
DR PDB; 4IIJ; X-ray; 2.60 A; B/D=1-445.
DR PDB; 4O2A; X-ray; 2.50 A; B/D=1-445.
DR PDB; 4O2B; X-ray; 2.30 A; B/D=1-445.
DR PDB; 4O4H; X-ray; 2.10 A; B/D=1-445.
DR PDB; 4O4I; X-ray; 2.40 A; B/D=1-445.
DR PDB; 4O4J; X-ray; 2.20 A; B/D=1-445.
DR PDB; 4O4L; X-ray; 2.20 A; B/D=1-445.
DR PDB; 4TUY; X-ray; 2.10 A; B/D=1-445.
DR PDB; 4TV8; X-ray; 2.10 A; B/D=1-445.
DR PDB; 4TV9; X-ray; 2.00 A; B/D=1-445.
DR PDB; 4UXO; EM; 6.30 A; B=1-445.
DR PDB; 4UXP; EM; 6.30 A; B=1-445.
DR PDB; 4UXR; EM; 7.00 A; B=1-445.
DR PDB; 4UXS; EM; 7.00 A; B=1-445.
DR PDB; 4UXT; EM; 7.40 A; B=1-445.
DR PDB; 4UXY; EM; 6.50 A; B=1-445.
DR PDB; 4UY0; EM; 7.70 A; B=2-427.
DR PDB; 4YJ2; X-ray; 2.60 A; B/D=1-445.
DR PDB; 4YJ3; X-ray; 3.75 A; B/D=1-445.
DR PDB; 5EIB; X-ray; 2.10 A; D=1-445.
DR PDB; 5EZY; X-ray; 2.05 A; B/D=1-445.
DR PDB; 5GON; X-ray; 2.48 A; B/D=1-431.
DR PDB; 5H74; X-ray; 2.60 A; B/D=1-445.
DR PDB; 5H7O; X-ray; 2.80 A; B/D=1-445.
DR PDB; 5HNW; EM; 6.60 A; B=2-445.
DR PDB; 5HNX; EM; 6.60 A; B=1-445.
DR PDB; 5HNY; EM; 6.30 A; B=2-427.
DR PDB; 5HNZ; EM; 5.80 A; B=1-445.
DR PDB; 5ITZ; X-ray; 2.20 A; B=1-445.
DR PDB; 5IYZ; X-ray; 1.80 A; B/D=1-445.
DR PDB; 5J2T; X-ray; 2.20 A; B/D=1-445.
DR PDB; 5J2U; X-ray; 2.50 A; B/D=1-445.
DR PDB; 5JH7; X-ray; 2.25 A; B/D=1-445.
DR PDB; 5JVD; X-ray; 2.39 A; B/D=1-445.
DR PDB; 5LA6; X-ray; 2.10 A; B/D=1-445.
DR PDB; 5LOV; X-ray; 2.40 A; B/D=1-445.
DR PDB; 5LP6; X-ray; 2.90 A; B/D=1-445.
DR PDB; 5LXS; X-ray; 2.20 A; B/D=1-445.
DR PDB; 5LXT; X-ray; 1.90 A; B/D=1-445.
DR PDB; 5LYJ; X-ray; 2.40 A; B/D=1-445.
DR PDB; 5M50; EM; 5.30 A; B/E=1-427.
DR PDB; 5M54; EM; 8.00 A; B/E=2-427.
DR PDB; 5M5C; EM; 4.80 A; B/E=2-427.
DR PDB; 5M5I; EM; 9.30 A; B=1-445.
DR PDB; 5M5L; EM; 9.30 A; B=1-445.
DR PDB; 5M5M; EM; 9.30 A; B=1-445.
DR PDB; 5M5N; EM; 9.30 A; B=1-445.
DR PDB; 5M5O; EM; 9.30 A; B=1-445.
DR PDB; 5M7E; X-ray; 2.05 A; B/D=1-445.
DR PDB; 5M7G; X-ray; 2.25 A; B/D=1-445.
DR PDB; 5M8D; X-ray; 2.25 A; B/D=1-445.
DR PDB; 5M8G; X-ray; 2.15 A; B/D=1-445.
DR PDB; 5MF4; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5ND2; EM; 5.80 A; B=1-445.
DR PDB; 5ND3; EM; 6.10 A; B=1-445.
DR PDB; 5ND4; EM; 4.40 A; B=2-427.
DR PDB; 5ND7; EM; 7.90 A; B=1-445.
DR PDB; 5NFZ; X-ray; 2.10 A; B/D=1-445.
DR PDB; 5NG1; X-ray; 2.20 A; B/D=1-445.
DR PDB; 5NJH; X-ray; 2.39 A; B/D=1-445.
DR PDB; 5NM5; X-ray; 2.05 A; B=1-445.
DR PDB; 5NQT; X-ray; 2.15 A; B=1-445.
DR PDB; 5NQU; X-ray; 1.80 A; B=1-445.
DR PDB; 5O7A; X-ray; 2.50 A; B/D=1-445.
DR PDB; 5OSK; X-ray; 2.11 A; B/D=1-445.
DR PDB; 5OV7; X-ray; 2.40 A; B/D=1-445.
DR PDB; 5S4L; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5S4M; X-ray; 2.15 A; B/D=1-445.
DR PDB; 5S4N; X-ray; 2.53 A; B/D=1-445.
DR PDB; 5S4O; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5S4P; X-ray; 2.29 A; B/D=1-445.
DR PDB; 5S4Q; X-ray; 2.59 A; B/D=1-445.
DR PDB; 5S4R; X-ray; 2.35 A; B/D=1-445.
DR PDB; 5S4S; X-ray; 2.35 A; B/D=1-445.
DR PDB; 5S4T; X-ray; 2.27 A; B/D=1-445.
DR PDB; 5S4U; X-ray; 2.39 A; B/D=1-445.
DR PDB; 5S4V; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5S4W; X-ray; 2.80 A; B/D=1-445.
DR PDB; 5S4X; X-ray; 2.53 A; B/D=1-445.
DR PDB; 5S4Y; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5S4Z; X-ray; 2.10 A; B/D=1-445.
DR PDB; 5S50; X-ray; 3.10 A; B/D=1-445.
DR PDB; 5S51; X-ray; 2.40 A; B/D=1-445.
DR PDB; 5S52; X-ray; 2.83 A; B/D=1-445.
DR PDB; 5S53; X-ray; 2.75 A; B/D=1-445.
DR PDB; 5S54; X-ray; 2.40 A; B/D=1-445.
DR PDB; 5S55; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5S56; X-ray; 2.25 A; B/D=1-445.
DR PDB; 5S57; X-ray; 2.45 A; B/D=1-445.
DR PDB; 5S58; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5S59; X-ray; 2.60 A; B/D=1-445.
DR PDB; 5S5A; X-ray; 2.35 A; B/D=1-445.
DR PDB; 5S5B; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5S5C; X-ray; 2.40 A; B/D=1-445.
DR PDB; 5S5D; X-ray; 1.90 A; B/D=1-445.
DR PDB; 5S5E; X-ray; 2.67 A; B/D=1-445.
DR PDB; 5S5F; X-ray; 2.24 A; B/D=1-445.
DR PDB; 5S5G; X-ray; 2.69 A; B/D=1-445.
DR PDB; 5S5H; X-ray; 2.50 A; B/D=1-445.
DR PDB; 5S5I; X-ray; 2.49 A; B/D=1-445.
DR PDB; 5S5J; X-ray; 2.25 A; B/D=1-445.
DR PDB; 5S5K; X-ray; 2.41 A; B/D=1-445.
DR PDB; 5S5L; X-ray; 2.25 A; B/D=1-445.
DR PDB; 5S5M; X-ray; 2.70 A; B/D=1-445.
DR PDB; 5S5N; X-ray; 2.90 A; B/D=1-445.
DR PDB; 5S5O; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5S5P; X-ray; 2.79 A; B/D=1-445.
DR PDB; 5S5Q; X-ray; 2.05 A; B/D=1-445.
DR PDB; 5S5R; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5S5S; X-ray; 2.36 A; B/D=1-445.
DR PDB; 5S5T; X-ray; 2.53 A; B/D=1-445.
DR PDB; 5S5U; X-ray; 2.50 A; B/D=1-445.
DR PDB; 5S5V; X-ray; 2.70 A; B/D=1-445.
DR PDB; 5S5W; X-ray; 2.35 A; B/D=1-445.
DR PDB; 5S5X; X-ray; 2.32 A; B/D=1-445.
DR PDB; 5S5Y; X-ray; 2.26 A; B/D=1-445.
DR PDB; 5S5Z; X-ray; 2.55 A; B/D=1-445.
DR PDB; 5S60; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5S61; X-ray; 1.95 A; B/D=1-445.
DR PDB; 5S62; X-ray; 2.75 A; B/D=1-445.
DR PDB; 5S63; X-ray; 2.60 A; B/D=1-445.
DR PDB; 5S64; X-ray; 2.75 A; B/D=1-445.
DR PDB; 5S65; X-ray; 2.25 A; B/D=1-445.
DR PDB; 5S66; X-ray; 2.10 A; B/D=1-445.
DR PDB; 5S67; X-ray; 2.10 A; B/D=1-445.
DR PDB; 5SB8; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5SB9; X-ray; 2.50 A; B/D=1-445.
DR PDB; 5SBA; X-ray; 2.25 A; B/D=1-445.
DR PDB; 5SBB; X-ray; 2.25 A; B/D=1-445.
DR PDB; 5SBC; X-ray; 2.32 A; B/D=1-445.
DR PDB; 5SBD; X-ray; 2.25 A; B/D=1-445.
DR PDB; 5SBE; X-ray; 2.75 A; B/D=1-445.
DR PDB; 5XAF; X-ray; 2.55 A; B/D=1-445.
DR PDB; 5XAG; X-ray; 2.56 A; B/D=1-445.
DR PDB; 5XLT; X-ray; 2.81 A; B/D=1-445.
DR PDB; 5XLZ; X-ray; 2.30 A; B/D=1-445.
DR PDB; 5YZ3; X-ray; 2.54 A; B/D=1-445.
DR PDB; 5Z4P; X-ray; 2.50 A; B=1-428, D=1-431.
DR PDB; 5Z4U; X-ray; 3.18 A; B/D=1-445.
DR PDB; 5ZXH; X-ray; 2.80 A; B/D=1-445.
DR PDB; 6AGK; X-ray; 2.80 A; B/D=1-445.
DR PDB; 6BBN; X-ray; 3.51 A; B/D=1-445.
DR PDB; 6EG5; X-ray; 2.45 A; B/D=1-445.
DR PDB; 6F7C; X-ray; 2.00 A; B/D=1-445.
DR PDB; 6FII; X-ray; 2.40 A; B/D=1-445.
DR PDB; 6FJF; X-ray; 2.40 A; B/D=1-445.
DR PDB; 6FJM; X-ray; 2.10 A; B/D=1-445.
DR PDB; 6FKJ; X-ray; 2.15 A; B/D=1-445.
DR PDB; 6FKL; X-ray; 2.10 A; B/D=1-445.
DR PDB; 6GF3; X-ray; 2.40 A; B/D=1-445.
DR PDB; 6GJ4; X-ray; 2.40 A; B/D=1-445.
DR PDB; 6GZE; X-ray; 2.49 A; B/D=1-445.
DR PDB; 6HX8; X-ray; 2.40 A; B/D=1-445.
DR PDB; 6I5C; X-ray; 2.95 A; B/D=1-445.
DR PDB; 6JCJ; X-ray; 2.50 A; B/D=1-445.
DR PDB; 6K9V; X-ray; 2.54 A; B/D=1-445.
DR PDB; 6KNZ; X-ray; 2.48 A; B/D=1-445.
DR PDB; 6N47; X-ray; 2.60 A; B/D=1-445.
DR PDB; 6OJQ; EM; 3.67 A; B=1-426.
DR PDB; 6QQN; X-ray; 2.30 A; B/D=1-445.
DR PDB; 6QTN; X-ray; 1.90 A; B/D=1-445.
DR PDB; 6REV; EM; 3.80 A; B/b=1-429.
DR PDB; 6RF2; EM; 4.20 A; B/b=1-429.
DR PDB; 6RF8; EM; 3.80 A; B/b=1-429.
DR PDB; 6RFD; EM; 3.90 A; B/b=1-429.
DR PDB; 6S8K; X-ray; 1.52 A; B=1-445.
DR PDB; 6S9E; X-ray; 2.25 A; B/D=1-445.
DR PDB; 6SES; X-ray; 2.00 A; B/D=1-445.
DR PDB; 6WVL; EM; 3.20 A; B/D=1-445.
DR PDB; 6WVM; EM; 3.30 A; B/D=1-445.
DR PDB; 6WVR; EM; 2.90 A; B/D=1-445.
DR PDB; 6Y6D; X-ray; 2.20 A; B/D=1-445.
DR PDB; 6ZWB; X-ray; 1.75 A; B=1-445.
DR PDB; 6ZWC; X-ray; 2.04 A; B=1-445.
DR PDB; 7AC5; X-ray; 2.26 A; B=1-445.
DR PDB; 7AU5; X-ray; 2.20 A; B/D=1-445.
DR PDB; 7CPD; X-ray; 2.51 A; B/D=1-445.
DR PDB; 7CPQ; X-ray; 2.60 A; B/D=1-445.
DR PDB; 7E4P; X-ray; 2.40 A; B/D=1-431.
DR PDB; 7E4Q; X-ray; 2.50 A; B/D=1-431.
DR PDB; 7E4R; X-ray; 2.60 A; B/D=1-431.
DR PDB; 7E4Y; X-ray; 2.71 A; B/D=1-431.
DR PDB; 7E4Z; X-ray; 2.69 A; B/D=1-431.
DR PDB; 7JFR; X-ray; 2.35 A; B/D=1-445.
DR PDB; 7OGN; X-ray; 2.20 A; B/D=1-445.
DR PDB; 7Z01; X-ray; 1.82 A; B=1-445.
DR PDB; 7Z02; X-ray; 2.36 A; B=1-445.
DR PDBsum; 1SA0; -.
DR PDBsum; 1SA1; -.
DR PDBsum; 1TVK; -.
DR PDBsum; 1Z2B; -.
DR PDBsum; 2P4N; -.
DR PDBsum; 2WBE; -.
DR PDBsum; 2XRP; -.
DR PDBsum; 3DCO; -.
DR PDBsum; 3DU7; -.
DR PDBsum; 3E22; -.
DR PDBsum; 3IZ0; -.
DR PDBsum; 3J1T; -.
DR PDBsum; 3J1U; -.
DR PDBsum; 3J2U; -.
DR PDBsum; 4AQV; -.
DR PDBsum; 4AQW; -.
DR PDBsum; 4ATU; -.
DR PDBsum; 4ATX; -.
DR PDBsum; 4CK5; -.
DR PDBsum; 4CK6; -.
DR PDBsum; 4CK7; -.
DR PDBsum; 4I4T; -.
DR PDBsum; 4I50; -.
DR PDBsum; 4I55; -.
DR PDBsum; 4IHJ; -.
DR PDBsum; 4IIJ; -.
DR PDBsum; 4O2A; -.
DR PDBsum; 4O2B; -.
DR PDBsum; 4O4H; -.
DR PDBsum; 4O4I; -.
DR PDBsum; 4O4J; -.
DR PDBsum; 4O4L; -.
DR PDBsum; 4TUY; -.
DR PDBsum; 4TV8; -.
DR PDBsum; 4TV9; -.
DR PDBsum; 4UXO; -.
DR PDBsum; 4UXP; -.
DR PDBsum; 4UXR; -.
DR PDBsum; 4UXS; -.
DR PDBsum; 4UXT; -.
DR PDBsum; 4UXY; -.
DR PDBsum; 4UY0; -.
DR PDBsum; 4YJ2; -.
DR PDBsum; 4YJ3; -.
DR PDBsum; 5EIB; -.
DR PDBsum; 5EZY; -.
DR PDBsum; 5GON; -.
DR PDBsum; 5H74; -.
DR PDBsum; 5H7O; -.
DR PDBsum; 5HNW; -.
DR PDBsum; 5HNX; -.
DR PDBsum; 5HNY; -.
DR PDBsum; 5HNZ; -.
DR PDBsum; 5ITZ; -.
DR PDBsum; 5IYZ; -.
DR PDBsum; 5J2T; -.
DR PDBsum; 5J2U; -.
DR PDBsum; 5JH7; -.
DR PDBsum; 5JVD; -.
DR PDBsum; 5LA6; -.
DR PDBsum; 5LOV; -.
DR PDBsum; 5LP6; -.
DR PDBsum; 5LXS; -.
DR PDBsum; 5LXT; -.
DR PDBsum; 5LYJ; -.
DR PDBsum; 5M50; -.
DR PDBsum; 5M54; -.
DR PDBsum; 5M5C; -.
DR PDBsum; 5M5I; -.
DR PDBsum; 5M5L; -.
DR PDBsum; 5M5M; -.
DR PDBsum; 5M5N; -.
DR PDBsum; 5M5O; -.
DR PDBsum; 5M7E; -.
DR PDBsum; 5M7G; -.
DR PDBsum; 5M8D; -.
DR PDBsum; 5M8G; -.
DR PDBsum; 5MF4; -.
DR PDBsum; 5ND2; -.
DR PDBsum; 5ND3; -.
DR PDBsum; 5ND4; -.
DR PDBsum; 5ND7; -.
DR PDBsum; 5NFZ; -.
DR PDBsum; 5NG1; -.
DR PDBsum; 5NJH; -.
DR PDBsum; 5NM5; -.
DR PDBsum; 5NQT; -.
DR PDBsum; 5NQU; -.
DR PDBsum; 5O7A; -.
DR PDBsum; 5OSK; -.
DR PDBsum; 5OV7; -.
DR PDBsum; 5S4L; -.
DR PDBsum; 5S4M; -.
DR PDBsum; 5S4N; -.
DR PDBsum; 5S4O; -.
DR PDBsum; 5S4P; -.
DR PDBsum; 5S4Q; -.
DR PDBsum; 5S4R; -.
DR PDBsum; 5S4S; -.
DR PDBsum; 5S4T; -.
DR PDBsum; 5S4U; -.
DR PDBsum; 5S4V; -.
DR PDBsum; 5S4W; -.
DR PDBsum; 5S4X; -.
DR PDBsum; 5S4Y; -.
DR PDBsum; 5S4Z; -.
DR PDBsum; 5S50; -.
DR PDBsum; 5S51; -.
DR PDBsum; 5S52; -.
DR PDBsum; 5S53; -.
DR PDBsum; 5S54; -.
DR PDBsum; 5S55; -.
DR PDBsum; 5S56; -.
DR PDBsum; 5S57; -.
DR PDBsum; 5S58; -.
DR PDBsum; 5S59; -.
DR PDBsum; 5S5A; -.
DR PDBsum; 5S5B; -.
DR PDBsum; 5S5C; -.
DR PDBsum; 5S5D; -.
DR PDBsum; 5S5E; -.
DR PDBsum; 5S5F; -.
DR PDBsum; 5S5G; -.
DR PDBsum; 5S5H; -.
DR PDBsum; 5S5I; -.
DR PDBsum; 5S5J; -.
DR PDBsum; 5S5K; -.
DR PDBsum; 5S5L; -.
DR PDBsum; 5S5M; -.
DR PDBsum; 5S5N; -.
DR PDBsum; 5S5O; -.
DR PDBsum; 5S5P; -.
DR PDBsum; 5S5Q; -.
DR PDBsum; 5S5R; -.
DR PDBsum; 5S5S; -.
DR PDBsum; 5S5T; -.
DR PDBsum; 5S5U; -.
DR PDBsum; 5S5V; -.
DR PDBsum; 5S5W; -.
DR PDBsum; 5S5X; -.
DR PDBsum; 5S5Y; -.
DR PDBsum; 5S5Z; -.
DR PDBsum; 5S60; -.
DR PDBsum; 5S61; -.
DR PDBsum; 5S62; -.
DR PDBsum; 5S63; -.
DR PDBsum; 5S64; -.
DR PDBsum; 5S65; -.
DR PDBsum; 5S66; -.
DR PDBsum; 5S67; -.
DR PDBsum; 5SB8; -.
DR PDBsum; 5SB9; -.
DR PDBsum; 5SBA; -.
DR PDBsum; 5SBB; -.
DR PDBsum; 5SBC; -.
DR PDBsum; 5SBD; -.
DR PDBsum; 5SBE; -.
DR PDBsum; 5XAF; -.
DR PDBsum; 5XAG; -.
DR PDBsum; 5XLT; -.
DR PDBsum; 5XLZ; -.
DR PDBsum; 5YZ3; -.
DR PDBsum; 5Z4P; -.
DR PDBsum; 5Z4U; -.
DR PDBsum; 5ZXH; -.
DR PDBsum; 6AGK; -.
DR PDBsum; 6BBN; -.
DR PDBsum; 6EG5; -.
DR PDBsum; 6F7C; -.
DR PDBsum; 6FII; -.
DR PDBsum; 6FJF; -.
DR PDBsum; 6FJM; -.
DR PDBsum; 6FKJ; -.
DR PDBsum; 6FKL; -.
DR PDBsum; 6GF3; -.
DR PDBsum; 6GJ4; -.
DR PDBsum; 6GZE; -.
DR PDBsum; 6HX8; -.
DR PDBsum; 6I5C; -.
DR PDBsum; 6JCJ; -.
DR PDBsum; 6K9V; -.
DR PDBsum; 6KNZ; -.
DR PDBsum; 6N47; -.
DR PDBsum; 6OJQ; -.
DR PDBsum; 6QQN; -.
DR PDBsum; 6QTN; -.
DR PDBsum; 6REV; -.
DR PDBsum; 6RF2; -.
DR PDBsum; 6RF8; -.
DR PDBsum; 6RFD; -.
DR PDBsum; 6S8K; -.
DR PDBsum; 6S9E; -.
DR PDBsum; 6SES; -.
DR PDBsum; 6WVL; -.
DR PDBsum; 6WVM; -.
DR PDBsum; 6WVR; -.
DR PDBsum; 6Y6D; -.
DR PDBsum; 6ZWB; -.
DR PDBsum; 6ZWC; -.
DR PDBsum; 7AC5; -.
DR PDBsum; 7AU5; -.
DR PDBsum; 7CPD; -.
DR PDBsum; 7CPQ; -.
DR PDBsum; 7E4P; -.
DR PDBsum; 7E4Q; -.
DR PDBsum; 7E4R; -.
DR PDBsum; 7E4Y; -.
DR PDBsum; 7E4Z; -.
DR PDBsum; 7JFR; -.
DR PDBsum; 7OGN; -.
DR PDBsum; 7Z01; -.
DR PDBsum; 7Z02; -.
DR AlphaFoldDB; Q6B856; -.
DR SASBDB; Q6B856; -.
DR SMR; Q6B856; -.
DR BioGRID; 158875; 3.
DR DIP; DIP-47524N; -.
DR IntAct; Q6B856; 7.
DR MINT; Q6B856; -.
DR STRING; 9913.ENSBTAP00000030869; -.
DR BindingDB; Q6B856; -.
DR ChEMBL; CHEMBL3394; -.
DR DrugCentral; Q6B856; -.
DR iPTMnet; Q6B856; -.
DR PaxDb; Q6B856; -.
DR PeptideAtlas; Q6B856; -.
DR PRIDE; Q6B856; -.
DR ABCD; Q6B856; 1 sequenced antibody.
DR GeneID; 281555; -.
DR KEGG; bta:281555; -.
DR CTD; 347733; -.
DR eggNOG; KOG1375; Eukaryota.
DR InParanoid; Q6B856; -.
DR OrthoDB; 962471at2759; -.
DR TreeFam; TF300298; -.
DR EvolutionaryTrace; Q6B856; -.
DR PRO; PR:Q6B856; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0015630; C:microtubule cytoskeleton; ISS:UniProtKB.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007017; P:microtubule-based process; ISS:UniProtKB.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:1902669; P:positive regulation of axon guidance; ISS:UniProtKB.
DR Gene3D; 1.10.287.600; -; 1.
DR Gene3D; 3.30.1330.20; -; 1.
DR Gene3D; 3.40.50.1440; -; 1.
DR InterPro; IPR013838; Beta-tubulin_BS.
DR InterPro; IPR002453; Beta_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; PTHR11588; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01163; BETATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF52490; SSF52490; 1.
DR SUPFAM; SSF55307; SSF55307; 1.
DR PROSITE; PS00227; TUBULIN; 1.
DR PROSITE; PS00228; TUBULIN_B_AUTOREG; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Cytoskeleton; GTP-binding;
KW Isopeptide bond; Methylation; Microtubule; Neurogenesis;
KW Nucleotide-binding; Phosphoprotein; Reference proteome; Ubl conjugation.
FT CHAIN 1..445
FT /note="Tubulin beta-2B chain"
FT /id="PRO_0000262654"
FT REGION 422..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 1..4
FT /note="MREI motif"
FT /evidence="ECO:0000250|UniProtKB:P07437"
FT COMPBIAS 431..445
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 40
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P99024"
FT MOD_RES 55
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q3KRE8"
FT MOD_RES 58
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P07437"
FT MOD_RES 58
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P99024"
FT MOD_RES 172
FT /note="Phosphoserine; by CDK1"
FT /evidence="ECO:0000250|UniProtKB:Q9BVA1"
FT MOD_RES 285
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P07437"
FT MOD_RES 290
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P07437"
FT MOD_RES 318
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:P07437"
FT MOD_RES 438
FT /note="5-glutamyl polyglutamate"
FT /evidence="ECO:0000250|UniProtKB:Q2T9S0"
FT CROSSLNK 58
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin); alternate"
FT /evidence="ECO:0000250|UniProtKB:P07437"
FT CROSSLNK 324
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:P07437"
FT CONFLICT 201
FT /note="C -> S (in Ref. 1; AAT84374)"
FT /evidence="ECO:0000305"
FT STRAND 4..9
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 10..28
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 34..36
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 39..41
FT /evidence="ECO:0007829|PDB:4IIJ"
FT HELIX 42..45
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 47..49
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 51..53
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 57..61
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 63..69
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 70..78
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 79..81
FT /evidence="ECO:0007829|PDB:5S5Q"
FT HELIX 82..84
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 87..89
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 90..92
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 101..106
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 108..125
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 126..128
FT /evidence="ECO:0007829|PDB:1TVK"
FT STRAND 132..142
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 143..158
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 162..170
FT /evidence="ECO:0007829|PDB:6S8K"
FT TURN 173..175
FT /evidence="ECO:0007829|PDB:5IYZ"
FT STRAND 177..179
FT /evidence="ECO:0007829|PDB:6GF3"
FT HELIX 181..195
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 197..203
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 204..213
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 222..241
FT /evidence="ECO:0007829|PDB:6S8K"
FT TURN 244..246
FT /evidence="ECO:0007829|PDB:6ZWB"
FT HELIX 250..257
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 259..262
FT /evidence="ECO:0007829|PDB:5S4S"
FT STRAND 265..272
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 278..280
FT /evidence="ECO:0007829|PDB:4I4T"
FT HELIX 286..294
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 296..298
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 299..302
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 305..307
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 310..320
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 323..336
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 338..340
FT /evidence="ECO:0007829|PDB:6S8K"
FT STRAND 343..345
FT /evidence="ECO:0007829|PDB:5M7E"
FT STRAND 349..356
FT /evidence="ECO:0007829|PDB:6S8K"
FT TURN 359..361
FT /evidence="ECO:0007829|PDB:5LOV"
FT STRAND 362..371
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 372..374
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 375..390
FT /evidence="ECO:0007829|PDB:6S8K"
FT TURN 391..395
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 396..399
FT /evidence="ECO:0007829|PDB:6S8K"
FT TURN 400..402
FT /evidence="ECO:0007829|PDB:6S8K"
FT HELIX 405..426
FT /evidence="ECO:0007829|PDB:6S8K"
SQ SEQUENCE 445 AA; 49953 MW; 4DC3956EFF880746 CRC64;
MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPTGSYHGDS DLQLERINVY YNEATGNKYV
PRAILVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDSVLDVV
RKESESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMNTFSVM PSPKVSDTVV
EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL
RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDSKNMM
AACDPRHGRY LTVAAIFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK TAVCDIPPRG
LKMSATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS
EYQQYQDATA DEQGEFEEEE GEDEA
