ID   AC34_NPVAC              Reviewed;         215 AA.
AC   P21287;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   29-SEP-2021, entry version 52.
DE   RecName: Full=Protein Ac34;
GN   Name=Ac34; ORFNames=ORF2;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2219715; DOI=10.1016/0042-6822(90)90266-t;
RA   Guarino L.A., Smith M.W.;
RT   "Nucleotide sequence and characterization of the 39K gene region of
RT   Autographa californica nuclear polyhedrosis virus.";
RL   Virology 179:1-8(1990).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH HOST P40; P34 AND P20.
RX   PubMed=27900558; DOI=10.1007/s12250-016-3912-4;
RA   Mu J., Zhang Y., Hu Y., Hu X., Zhou Y., Chen X., Wang Y.;
RT   "The role of viral protein Ac34 in nuclear relocation of subunits of the
RT   actin-related protein 2/3 complex.";
RL   Virol. Sin. 31:480-489(2016).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=27802336; DOI=10.1371/journal.ppat.1005994;
RA   Mu J., Zhang Y., Hu Y., Hu X., Zhou Y., Zhao H., Pei R., Wu C., Chen J.,
RA   Zhao H., Yang K., Oers M.M., Chen X., Wang Y.;
RT   "Autographa californica Multiple Nucleopolyhedrovirus Ac34 Protein Retains
RT   Cellular Actin-Related Protein 2/3 Complex in the Nucleus by Subversion of
RT   CRM1-Dependent Nuclear Export.";
RL   PLoS Pathog. 12:E1005994-E1005994(2016).
CC   -!- FUNCTION: Plays a role in the translocation of the P40 subunit of host
CC       Arp2/3 to the nucleus. The robust nuclear accumulation of Arp2/3
CC       induces nuclear actin polymerization to assist in virus replication.
CC       Mechanistically, subverts the host CRM1-dependent nuclear export
CC       pathway leading to Arp2/3 acumulation in the host nucleus.
CC       {ECO:0000269|PubMed:27802336, ECO:0000269|PubMed:27900558}.
CC   -!- SUBUNIT: Interacts with host proteins P40, P34 ands P20.
CC       {ECO:0000269|PubMed:27900558}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:27802336}.
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DR   EMBL; L22858; AAA66664.1; -; Genomic_DNA.
DR   EMBL; M37122; AAA46686.1; -; Genomic_DNA.
DR   PIR; B72854; B72854.
DR   PIR; F45355; F45355.
DR   RefSeq; NP_054063.1; NC_001623.1.
DR   GeneID; 1403866; -.
DR   KEGG; vg:1403866; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009657; Protein_Ac34.
DR   Pfam; PF06851; DUF1247; 1.
PE   1: Evidence at protein level;
KW   Host nucleus; Reference proteome.
FT   CHAIN           1..215
FT                   /note="Protein Ac34"
FT                   /id="PRO_0000132973"
FT   CONFLICT        53..54
FT                   /note="ND -> DA (in Ref. 2; AAA46686)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   215 AA;  24885 MW;  C58FEF2FF6F4A99D CRC64;
     MTTVAVNAPL PPPLVELCNR RPIPTPRIIS LQRQLISTPV VKNYQADVQE AINDFKRLNI
     TPGHLGEVID TMGQQGKLLP EIIEADDDFK VNQTRNLSCK TVEYLNFLEN DKLFRCRLCY
     THADWLWCDF HRNHAYRGTR DITCNNYVEH LNSDMGVVML IEEYFYCLSS CNFKQDAKRA
     LQTLTKFESL SDLMASYNFS TPDLDTNAYE LMDFE