位置:首页 > 蛋白库 > TBB_EUGGR
TBB_EUGGR
ID   TBB_EUGGR               Reviewed;         442 AA.
AC   P12457;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Tubulin beta chain;
DE   AltName: Full=Beta-tubulin;
GN   Name=TUBB;
OS   Euglena gracilis.
OC   Eukaryota; Discoba; Euglenozoa; Euglenida; Spirocuta; Euglenophyceae;
OC   Euglenales; Euglenaceae; Euglena.
OX   NCBI_TaxID=3039;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Z 1224 5/25;
RX   PubMed=2506525; DOI=10.1093/nar/17.16.6727;
RA   Schantz M.-L., Schantz R.;
RT   "Sequence of a cDNA clone encoding beta tubulin from Euglena gracilis.";
RL   Nucleic Acids Res. 17:6727-6727(1989).
CC   -!- FUNCTION: Tubulin is the major constituent of microtubules. It binds
CC       two moles of GTP, one at an exchangeable site on the beta chain and one
CC       at a non-exchangeable site on the alpha chain.
CC   -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC       hollow water-filled tube with an outer diameter of 25 nm and an inner
CC       diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC       form protofilaments running lengthwise along the microtubule wall with
CC       the beta-tubulin subunit facing the microtubule plus end conferring a
CC       structural polarity. Microtubules usually have 13 protofilaments but
CC       different protofilament numbers can be found in some organisms and
CC       specialized cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X15797; CAA33797.1; -; mRNA.
DR   PIR; S05496; S05496.
DR   AlphaFoldDB; P12457; -.
DR   SMR; P12457; -.
DR   PRIDE; P12457; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   Gene3D; 1.10.287.600; -; 1.
DR   Gene3D; 3.30.1330.20; -; 1.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR013838; Beta-tubulin_BS.
DR   InterPro; IPR002453; Beta_tubulin.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR   InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR023123; Tubulin_C.
DR   InterPro; IPR017975; Tubulin_CS.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   Pfam; PF03953; Tubulin_C; 1.
DR   PRINTS; PR01163; BETATUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SMART; SM00864; Tubulin; 1.
DR   SMART; SM00865; Tubulin_C; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
DR   SUPFAM; SSF55307; SSF55307; 1.
DR   PROSITE; PS00227; TUBULIN; 1.
DR   PROSITE; PS00228; TUBULIN_B_AUTOREG; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding.
FT   CHAIN           1..442
FT                   /note="Tubulin beta chain"
FT                   /id="PRO_0000048346"
FT   BINDING         138..144
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   442 AA;  49418 MW;  F25CBFA9C7496989 CRC64;
     MREIVHIQAG QCGNQIGSKF WEVISDEQGV DPPDIPGDSD LQLERINVYY NEATGGRYVP
     AILMDLEPGT MDSVRAGPYG QIFRPDNFVF GQTGAGNNWA KGHYTEGPEL IDSVLDVVRK
     EAESCDCLQG FQIAHSLGGG TGSGMGTLLI SKIREEYPDR MMMTFSVIPS PKVSDTVVEP
     YNTTLSVHQL VENADEVMCI GNEALYDICL PTLKLTTPTF GHETLVSAVM SGVTCCLRFP
     GQLNSDLRKL AVNLIPFPRL HFFLVGFAPL TSRGSQQYRA LTVPELTQQM FDAKNMMAAS
     DPAHGRYLTA SAMFRGRMST KEVDEQMLNV QNKNSSYFVE WIPNNIKSSV CDIPPKGLKM
     SATFIGNNTA IQEMFKRVSE QFTAMFRRKA FLHWYTGEGM DEMEFTEAES NMNDLVSEYQ
     QYQDATVEEE GEFDEEEDVE QY
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024