ID   TBB_GIAIN               Reviewed;         446 AA.
AC   P05304;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 3.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Tubulin beta chain;
DE   AltName: Full=Beta-tubulin;
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3267222; DOI=10.1093/nar/16.6.2733;
RA   Kirk-Mason K.E., Turner M.J., Chakraborty P.R.;
RT   "Cloning and sequence of beta tubulin cDNA from Giardia lamblia.";
RL   Nucleic Acids Res. 16:2733-2733(1988).
CC   -!- FUNCTION: Tubulin is the major constituent of microtubules. It binds
CC       two moles of GTP, one at an exchangeable site on the beta chain and one
CC       at a non-exchangeable site on the alpha chain.
CC   -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC       hollow water-filled tube with an outer diameter of 25 nm and an inner
CC       diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC       form protofilaments running lengthwise along the microtubule wall with
CC       the beta-tubulin subunit facing the microtubule plus end conferring a
CC       structural polarity. Microtubules usually have 13 protofilaments but
CC       different protofilament numbers can be found in some organisms and
CC       specialized cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X06748; CAA29923.1; -; mRNA.
DR   PIR; S00743; S00743.
DR   AlphaFoldDB; P05304; -.
DR   SMR; P05304; -.
DR   PRIDE; P05304; -.
DR   VEuPathDB; GiardiaDB:DHA2_153187; -.
DR   VEuPathDB; GiardiaDB:GL50581_1380; -.
DR   VEuPathDB; GiardiaDB:GL50803_00136021; -.
DR   eggNOG; KOG1375; Eukaryota.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   Gene3D; 1.10.287.600; -; 1.
DR   Gene3D; 3.30.1330.20; -; 1.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR013838; Beta-tubulin_BS.
DR   InterPro; IPR002453; Beta_tubulin.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR   InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR023123; Tubulin_C.
DR   InterPro; IPR017975; Tubulin_CS.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   Pfam; PF03953; Tubulin_C; 1.
DR   PRINTS; PR01163; BETATUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SMART; SM00864; Tubulin; 1.
DR   SMART; SM00865; Tubulin_C; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
DR   SUPFAM; SSF55307; SSF55307; 1.
DR   PROSITE; PS00227; TUBULIN; 1.
DR   PROSITE; PS00228; TUBULIN_B_AUTOREG; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding.
FT   CHAIN           1..446
FT                   /note="Tubulin beta chain"
FT                   /id="PRO_0000048297"
FT   REGION          427..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        428..446
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         140..146
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   446 AA;  49956 MW;  517FA5DDCE288FC7 CRC64;
     MREIVHIQAG QCGNQIGAKF WEVISDEHGV DPSGEYRGDS ELQIERINVY FNEAAGGRYV
     PRAILVDLEP GTMDSVRAGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDAVLDVV
     RKRSEACDCL QGFQICHSLG GGTGAGMGTL LIAKIREEYP DRMMCTFSVV PSPKVSDTVV
     EPYNATLSVH QLVEHADEVF CIDNEALYDI CFRTLKLTCP TYGDLNHLVS LVMSGCTSCL
     RFPGQLNADL RKLAVNLIPF PRLHFFLVGF APLTSRGSQI YRALTVPELV SQMFDNKNMM
     AASDPRHGRY LTAAAMFRGR MSTKEVDEQM LNIQNKNSSY FVEWIPNNMK VSVCDIPPRG
     LKMAATFIGN STCIQELFKR VGEQFSAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS
     EYQQYQEAGV DEGEEFEEEE DFGDEQ