ID   TBC12_XENTR             Reviewed;         684 AA.
AC   Q0IHY4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=TBC1 domain family member 12;
GN   Name=tbc1d12;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a GTPase-activating protein for Rab family
CC       protein(s).
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DR   EMBL; BC122911; AAI22912.1; -; mRNA.
DR   RefSeq; NP_001072568.1; NM_001079100.1.
DR   AlphaFoldDB; Q0IHY4; -.
DR   SMR; Q0IHY4; -.
DR   STRING; 8364.ENSXETP00000060998; -.
DR   PaxDb; Q0IHY4; -.
DR   Ensembl; ENSXETT00000073144; ENSXETP00000084388; ENSXETG00000030404.
DR   GeneID; 780023; -.
DR   KEGG; xtr:780023; -.
DR   CTD; 23232; -.
DR   eggNOG; KOG2223; Eukaryota.
DR   InParanoid; Q0IHY4; -.
DR   OrthoDB; 798837at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000030404; Expressed in early embryo and 13 other tissues.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; GTPase activation; Reference proteome.
FT   CHAIN           1..684
FT                   /note="TBC1 domain family member 12"
FT                   /id="PRO_0000327656"
FT   DOMAIN          392..602
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          119..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          169..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          219..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          331..365
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        251..275
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   684 AA;  76874 MW;  B6F5A8A72CB1D4CA CRC64;
     MVGPEDAGQG AVYRCGEERH GLTDAADEEE GEGEAGDRQT DILQLYISRP AIKMTNGDLN
     YLPQGGAGEG DMPSAGDMHS LSTHKEDIKQ PNGGLLVADS TRPQGCACHR QCCSLSEAVP
     SPGTPPGSSP ISSSSSSPVS ARTVAGYFVS EEADRFRFLD VSRQSCRNTF EGSRRQSAPD
     HLADGLSLPA ESPGTAEQDG DRPWKVGIAE FFSRNFFSKR TKDPKSSSSV PGWKLFGKVP
     PRETAQKDSK IIQQDDSSGS LSSVSTPNLL NTGEYEARTG RSCKAPSQST RKKKFEFEPL
     STTALILEDR PSNLPAKSVH ETLRHRQEYD EMVAEAKKRE VKEAQRRKKL MKERIRQEEN
     IASAMVIWNT EILPNWDVMR STRRVRDLWW QGLPPSIRGK VWSLAIGNEL NITPELYEIF
     LSRAKERWKS FSETNSENEN EDAGASLADR EASLELIKLD ISRTFPSLYI FQKGGPYHDL
     LHSILGAYTC YRPDVGYVQG MSFIAAVLIL NLEEADAFIA FANLLNKPCQ LAFFRVDHSM
     MLKYFAAFEV FFEENLPKLF FHFNAYSLTP DLYLIDWIFT LYSKSLPLDL ACRVWDVFCR
     DGEEFLFRTA LGILRLYEDI LLQMDFIHIA QFLTKLPEDI TSEKLFGCIA AIQMQNSNKK
     WTQVFTSLMK DYKEGDKMSQ ASKT