ID   TBC13_MOUSE             Reviewed;         400 AA.
AC   Q8R3D1;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=TBC1 domain family member 13;
GN   Name=Tbc1d13;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Kidney, Pancreas, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH RAB1A AND RAB10, AND
RP   TISSUE SPECIFICITY.
RX   PubMed=22762500; DOI=10.1111/j.1600-0854.2012.01397.x;
RA   Davey J.R., Humphrey S.J., Junutula J.R., Mishra A.K., Lambright D.G.,
RA   James D.E., Stoeckli J.;
RT   "TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4
RT   trafficking in adipocytes.";
RL   Traffic 13:1429-1441(2012).
CC   -!- FUNCTION: Acts as a GTPase-activating protein for RAB35. Together with
CC       RAB35 may be involved in regulation of insulin-induced glucose
CC       transporter SLC2A4/GLUT4 translocation to the plasma membrane in
CC       adipocytes. {ECO:0000269|PubMed:22762500}.
CC   -!- SUBUNIT: Interacts with RAB1A and RAB10; in a GTP-dependent manner.
CC       {ECO:0000269|PubMed:22762500}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:22762500}. Cytoplasm
CC       {ECO:0000269|PubMed:22762500}.
CC   -!- TISSUE SPECIFICITY: Expressed in adipocytes.
CC       {ECO:0000269|PubMed:22762500}.
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DR   EMBL; BC025586; AAH25586.1; -; mRNA.
DR   CCDS; CCDS15871.1; -.
DR   RefSeq; NP_666364.1; NM_146252.3.
DR   AlphaFoldDB; Q8R3D1; -.
DR   SMR; Q8R3D1; -.
DR   STRING; 10090.ENSMUSP00000048426; -.
DR   iPTMnet; Q8R3D1; -.
DR   PhosphoSitePlus; Q8R3D1; -.
DR   EPD; Q8R3D1; -.
DR   MaxQB; Q8R3D1; -.
DR   PaxDb; Q8R3D1; -.
DR   PRIDE; Q8R3D1; -.
DR   ProteomicsDB; 263130; -.
DR   Antibodypedia; 31273; 141 antibodies from 20 providers.
DR   Ensembl; ENSMUST00000044556; ENSMUSP00000048426; ENSMUSG00000039678.
DR   GeneID; 70296; -.
DR   KEGG; mmu:70296; -.
DR   UCSC; uc008jbj.1; mouse.
DR   CTD; 54662; -.
DR   MGI; MGI:2385326; Tbc1d13.
DR   VEuPathDB; HostDB:ENSMUSG00000039678; -.
DR   eggNOG; KOG4567; Eukaryota.
DR   GeneTree; ENSGT00940000158674; -.
DR   HOGENOM; CLU_018687_0_0_1; -.
DR   InParanoid; Q8R3D1; -.
DR   OMA; IHICCAM; -.
DR   OrthoDB; 683074at2759; -.
DR   PhylomeDB; Q8R3D1; -.
DR   TreeFam; TF105911; -.
DR   Reactome; R-MMU-8854214; TBC/RABGAPs.
DR   BioGRID-ORCS; 70296; 1 hit in 74 CRISPR screens.
DR   PRO; PR:Q8R3D1; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q8R3D1; protein.
DR   Bgee; ENSMUSG00000039678; Expressed in yolk sac and 193 other tissues.
DR   ExpressionAtlas; Q8R3D1; baseline and differential.
DR   Genevisible; Q8R3D1; MM.
DR   GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR   GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR   GO; GO:0005096; F:GTPase activator activity; IDA:UniProtKB.
DR   GO; GO:0031267; F:small GTPase binding; IDA:UniProtKB.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IDA:UniProtKB.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; GTPase activation; Membrane; Reference proteome.
FT   CHAIN           1..400
FT                   /note="TBC1 domain family member 13"
FT                   /id="PRO_0000208039"
FT   DOMAIN          35..345
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
SQ   SEQUENCE   400 AA;  46453 MW;  C2606C961CBF4EF4 CRC64;
     MSSLHKSRIA DFQDVLKEPS IVLEKLRELS FSGIPCEGGL RCLCWKILLN YLPLERASWT
     SILAKQRGLY SQFLREMIIQ PGIAKANMGV FREDVTFEDH PLNPNPDSRW NTYFKDNEVL
     LQIDKDVRRL CPDISFFQRA TEYPCLLILD PQNEFETLRK RVEQTTLKSQ TVARNRSGVT
     NMSSPHKNSA PSALNEYEVL PNGCEAHWEV VERILFIYAK LNPGIAYVQG MNEIVGPLYY
     TFATDPNSEW KEHAEADTFF CFTNLMAEIR DNFIKSLDDS QCGITYKMEK VYSTLKDKDV
     ELYLKLQEQS IKPQFFAFRW LTLLLSQEFL LPDVIRIWDS LFADGNRFDF LLLVCCAMLI
     LIREQLLEGD FTVNMRLLQD YPITDVCQIL QKAKELQDSK