ID   TBC23_CHICK             Reviewed;         679 AA.
AC   Q5F415;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=TBC1 domain family member 23;
GN   Name=TBC1D23; ORFNames=RCJMB04_3n7;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Putative Rab GTPase-activating protein which plays a role in
CC       vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts
CC       as a bridging protein by binding simultaneously to golgins, located at
CC       the trans-Golgi, and to the WASH complex, located on endosome-derived
CC       vesicles (By similarity). Plays a role in brain development (By
CC       similarity). May act as a general inhibitor of innate immunity
CC       signaling (By similarity). {ECO:0000250|UniProtKB:Q7SXV1,
CC       ECO:0000250|UniProtKB:Q8K0F1, ECO:0000250|UniProtKB:Q9NUY8}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC       {ECO:0000250|UniProtKB:Q9NUY8}.
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DR   EMBL; AJ851485; CAH65119.1; -; mRNA.
DR   RefSeq; NP_001025955.1; NM_001030784.1.
DR   AlphaFoldDB; Q5F415; -.
DR   SMR; Q5F415; -.
DR   STRING; 9031.ENSGALP00000024604; -.
DR   PaxDb; Q5F415; -.
DR   GeneID; 418383; -.
DR   KEGG; gga:418383; -.
DR   CTD; 55773; -.
DR   VEuPathDB; HostDB:geneid_418383; -.
DR   eggNOG; KOG3636; Eukaryota.
DR   InParanoid; Q5F415; -.
DR   OrthoDB; 429640at2759; -.
DR   PhylomeDB; Q5F415; -.
DR   PRO; PR:Q5F415; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:1990403; P:embryonic brain development; ISS:UniProtKB.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   GO; GO:0099041; P:vesicle tethering to Golgi; IBA:GO_Central.
DR   Gene3D; 3.40.250.10; -; 1.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR036873; Rhodanese-like_dom_sf.
DR   InterPro; IPR039755; TBC1D23.
DR   InterPro; IPR045799; TBC1D23_C.
DR   PANTHER; PTHR13297; PTHR13297; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   Pfam; PF00581; Rhodanese; 1.
DR   Pfam; PF19430; TBC1D23_C; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   SUPFAM; SSF52821; SSF52821; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Golgi apparatus; Reference proteome.
FT   CHAIN           1..679
FT                   /note="TBC1 domain family member 23"
FT                   /id="PRO_0000287500"
FT   DOMAIN          38..219
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   DOMAIN          327..439
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
FT   REGION          454..478
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   679 AA;  76011 MW;  F4A773DD807909C9 CRC64;
     MAEGDGAPPS SWEKDLAEAL EEGGCDLETV RNIIQGRQLP ADLRAKVWKI ALNVVGKGDS
     LASWDGCLDL PEQSIIHKDC QELIDRLSVP EDEKSVLLLD IESVITFYCK SRNVKYSSCL
     GWIHLLRPLV HLRLPRSDLY NCFYAIMNKY IPRDCFLKGR PFHLFRLLLQ YHEPELCSFL
     DTKKMTPDSY ALNWLGSLFS YYCSTEVTQA IWDGYLQQAD PFFIYFLMLI ILVNAKDVIL
     AQESEKEEML KFLETSPANL EVEDIEDLFS LAQYYCSKTP ASFRKDNHSL FGSSLLGLKD
     DDTDLSQALC LAVSVSEILQ ANQQQGEGVR FFVVDCRPAE QYNAGHLSTA FHLDSDLMLQ
     NPSEFAQSVK SLLEAQKQSI ESGSIAGGEH LCFMGSGREE EDMYMNMVLA HFLQKNKEYV
     SIARGGFMAL QQHLADINVE GPENGYGHWI ASTSGSRSSI NSSVDGDSPN GSSDGKGVKS
     LVNKMTVALK TKSVNVKEKV ISFIENTSTP VDRHVSSSDR VGKPYRGVKP VFSIGDEEEY
     DTDGIDSSSM SDDDRKEVVN IQTWINKPDV KYNFPCNEVK ENGHMFPSHL LVTATNMYCL
     REIPSRKGLA YIQSRQALNS VVKITSKKKH PELITFKYGN SNTSGIEILA VERYLIPNAG
     DATKAIKQQI MKVLDALES