ID   TBC23_XENLA             Reviewed;         682 AA.
AC   Q6NRC7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=TBC1 domain family member 23;
GN   Name=tbc1d23;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative Rab GTPase-activating protein which plays a role in
CC       vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts
CC       as a bridging protein by binding simultaneously to golgins, located at
CC       the trans-Golgi, and to the WASH complex, located on endosome-derived
CC       vesicles (By similarity). Plays a role in brain development (By
CC       similarity). May act as a general inhibitor of innate immunity
CC       signaling (By similarity). {ECO:0000250|UniProtKB:Q7SXV1,
CC       ECO:0000250|UniProtKB:Q8K0F1, ECO:0000250|UniProtKB:Q9NUY8}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC       {ECO:0000250|UniProtKB:Q9NUY8}. Cytoplasmic vesicle
CC       {ECO:0000250|UniProtKB:Q9NUY8}.
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DR   EMBL; BC070830; AAH70830.1; -; mRNA.
DR   RefSeq; NP_001084850.1; NM_001091381.1.
DR   AlphaFoldDB; Q6NRC7; -.
DR   SMR; Q6NRC7; -.
DR   DNASU; 431896; -.
DR   GeneID; 431896; -.
DR   KEGG; xla:431896; -.
DR   CTD; 431896; -.
DR   Xenbase; XB-GENE-5893511; tbc1d23.S.
DR   OrthoDB; 429640at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 431896; Expressed in liver and 19 other tissues.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
DR   GO; GO:1990403; P:embryonic brain development; ISS:UniProtKB.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR   GO; GO:0099041; P:vesicle tethering to Golgi; ISS:UniProtKB.
DR   Gene3D; 3.40.250.10; -; 1.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR036873; Rhodanese-like_dom_sf.
DR   InterPro; IPR039755; TBC1D23.
DR   InterPro; IPR045799; TBC1D23_C.
DR   PANTHER; PTHR13297; PTHR13297; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   Pfam; PF00581; Rhodanese; 1.
DR   Pfam; PF19430; TBC1D23_C; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 1.
DR   SUPFAM; SSF52821; SSF52821; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Developmental protein; Golgi apparatus;
KW   Reference proteome.
FT   CHAIN           1..682
FT                   /note="TBC1 domain family member 23"
FT                   /id="PRO_0000287502"
FT   DOMAIN          29..210
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   DOMAIN          318..426
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
SQ   SEQUENCE   682 AA;  76850 MW;  AAD2C7BF9699A044 CRC64;
     MCREADLSEA LEAGGCDLET VRNIIQGRPV PCDLRTKVWK IALNVSGKGD SLASWDGSLD
     LQEQPLIHRD CQNLIDRLSV AEERKTALLE DIESVVTFYC KSRNVKYQED ASWIHLLNPL
     VGLQLPRSDL YNCFYAIMNK YIPRDCNRKG KPFHLFRLLL QYHEPELCSF LDTKKITPDL
     YALNWFGSLF AFHCSVEVTQ AIWDNYLQQA DPFFMYFLML IMLVNSKETV LGQDMDDKEE
     LIKCLENTPS SLEVEDIEDL FSLAQYYYSK TPASFRKDHQ SLFGSSLIAF KDDTDLSQAL
     CLAVSVSEIL QANQQQGDGV RFFVVDCRPA EQYNSGHLST AFHLDSDLML QNPGEFALSV
     KSLLEAQKQS IESGSIAGGE HLCFMGSGRD EEDMYINMVL AHFLQKNKEY ISIAKGGFMA
     LQQHLADFNM ENGYGHWIVS TSGSHSSISM YADGDSAVAA DDGKGMKSLV NKMTVAFKTK
     SVNVKDKVIS FIENTATPVD RITFNIPWPE RASLERHVSS SDRVGKPYRG VKPVFSIGDE
     EEYDTDEVDS SSMSDDDRKE IVNVQTWINK PDVKHHFPCD EVKDNGHRFP SHLLVTATHM
     YCLREILSKK GFAYIQSRQA LSTVVKITSK KKHPELITFK YGSSNASGVE ISAVERYLIP
     NAGDATKAIK QQIMKVLDAL ES