ID   TBC28_HUMAN             Reviewed;         210 AA.
AC   Q2M2D7; Q2M2E1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=TBC1 domain family member 28;
GN   Name=TBC1D28;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CAUTION: The Rab-GAP TBC domain is short and lacks the C-terminal part.
CC       It is therefore unclear whether the protein has GTPase-activating
CC       activity. {ECO:0000305}.
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DR   EMBL; BC112012; AAI12013.1; -; mRNA.
DR   EMBL; BC112016; AAI12017.1; -; mRNA.
DR   CCDS; CCDS42273.1; -.
DR   RefSeq; NP_001034486.2; NM_001039397.2.
DR   AlphaFoldDB; Q2M2D7; -.
DR   SMR; Q2M2D7; -.
DR   BioGRID; 129028; 6.
DR   IntAct; Q2M2D7; 2.
DR   STRING; 9606.ENSP00000339973; -.
DR   iPTMnet; Q2M2D7; -.
DR   PhosphoSitePlus; Q2M2D7; -.
DR   BioMuta; TBC1D28; -.
DR   DMDM; 121941423; -.
DR   PaxDb; Q2M2D7; -.
DR   PeptideAtlas; Q2M2D7; -.
DR   PRIDE; Q2M2D7; -.
DR   Antibodypedia; 63424; 99 antibodies from 13 providers.
DR   DNASU; 254272; -.
DR   Ensembl; ENST00000345096.8; ENSP00000339973.4; ENSG00000189375.12.
DR   Ensembl; ENST00000405044.6; ENSP00000385821.1; ENSG00000189375.12.
DR   GeneID; 254272; -.
DR   KEGG; hsa:254272; -.
DR   MANE-Select; ENST00000405044.7; ENSP00000385821.1; NM_001039397.3; NP_001034486.2.
DR   UCSC; uc002gud.2; human.
DR   CTD; 254272; -.
DR   GeneCards; TBC1D28; -.
DR   HGNC; HGNC:26858; TBC1D28.
DR   HPA; ENSG00000189375; Tissue enriched (testis).
DR   neXtProt; NX_Q2M2D7; -.
DR   PharmGKB; PA162405287; -.
DR   VEuPathDB; HostDB:ENSG00000189375; -.
DR   eggNOG; KOG1102; Eukaryota.
DR   GeneTree; ENSGT00940000162039; -.
DR   HOGENOM; CLU_005350_9_2_1; -.
DR   InParanoid; Q2M2D7; -.
DR   OMA; WIMHETE; -.
DR   OrthoDB; 976276at2759; -.
DR   PhylomeDB; Q2M2D7; -.
DR   TreeFam; TF343904; -.
DR   PathwayCommons; Q2M2D7; -.
DR   SignaLink; Q2M2D7; -.
DR   BioGRID-ORCS; 254272; 53 hits in 1025 CRISPR screens.
DR   ChiTaRS; TBC1D28; human.
DR   GenomeRNAi; 254272; -.
DR   Pharos; Q2M2D7; Tdark.
DR   PRO; PR:Q2M2D7; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q2M2D7; protein.
DR   Bgee; ENSG00000189375; Expressed in sperm and 36 other tissues.
DR   ExpressionAtlas; Q2M2D7; baseline and differential.
DR   Genevisible; Q2M2D7; HS.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..210
FT                   /note="TBC1 domain family member 28"
FT                   /id="PRO_0000337020"
FT   DOMAIN          101..210
FT                   /note="Rab-GAP TBC"
FT   CONFLICT        56
FT                   /note="E -> A (in Ref. 1; AAI12013)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   210 AA;  24072 MW;  A55A677E5D26B42E CRC64;
     MEMDEDPDNL PAQGQGNIII TKYEQGHRAG AAVDLGHEQV DVRKYTNNLG IVHEMELPRV
     SALEVKQRRK ESKRTNKWQK MLADWTKYRS TKKLSQRVCK VIPLAVRGRA LSLLLDIDKI
     KSQNPGKYKV MKEKGKRSSR IIHCIQLDVS HTLQKHMMFI QRFGVKQQEL CDILVAYSAY
     NPVSIPGQRY SWYLCPYSQA WVSLGGVATS