TBC31_MOUSE
ID TBC31_MOUSE Reviewed; 996 AA.
AC Q6NXY1; Q3TBW4; Q3U4F6; Q5KSA3; Q810J7; Q8C3Y2;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=TBC1 domain family member 31;
DE AltName: Full=Protein 4-B-3;
DE AltName: Full=WD repeat-containing protein 67;
GN Name=Tbc1d31; Synonyms=Wdr67;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-833 (ISOFORM 1).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Dendritic cell, and Embryonic heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Embryonic germ cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-833 (ISOFORM 1).
RC TISSUE=Neuron;
RA Ishii T., Tomooka Y.;
RT "Mus musculus hypothetical protein 4-B-3.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6NXY1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NXY1-4; Sequence=VSP_016185, VSP_016186, VSP_016187;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD83881.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BAE32475.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC Sequence=BAE42193.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
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DR EMBL; AK084542; BAC39214.1; -; mRNA.
DR EMBL; AK154264; BAE32475.1; ALT_SEQ; mRNA.
DR EMBL; AK171024; BAE42193.1; ALT_SEQ; mRNA.
DR EMBL; BC050039; AAH50039.1; -; mRNA.
DR EMBL; BC066830; AAH66830.1; -; mRNA.
DR EMBL; AB185844; BAD83881.1; ALT_SEQ; mRNA.
DR CCDS; CCDS37077.2; -. [Q6NXY1-1]
DR RefSeq; NP_001074865.2; NM_001081396.2. [Q6NXY1-1]
DR RefSeq; NP_001161151.1; NM_001167679.1.
DR AlphaFoldDB; Q6NXY1; -.
DR SMR; Q6NXY1; -.
DR BioGRID; 229163; 2.
DR IntAct; Q6NXY1; 1.
DR STRING; 10090.ENSMUSP00000022992; -.
DR iPTMnet; Q6NXY1; -.
DR PhosphoSitePlus; Q6NXY1; -.
DR EPD; Q6NXY1; -.
DR MaxQB; Q6NXY1; -.
DR PaxDb; Q6NXY1; -.
DR PRIDE; Q6NXY1; -.
DR ProteomicsDB; 254653; -. [Q6NXY1-1]
DR ProteomicsDB; 254654; -. [Q6NXY1-4]
DR Antibodypedia; 13779; 40 antibodies from 11 providers.
DR Ensembl; ENSMUST00000022992; ENSMUSP00000022992; ENSMUSG00000022364. [Q6NXY1-1]
DR GeneID; 210544; -.
DR KEGG; mmu:210544; -.
DR UCSC; uc007vss.1; mouse. [Q6NXY1-1]
DR UCSC; uc007vsy.1; mouse. [Q6NXY1-4]
DR CTD; 93594; -.
DR MGI; MGI:2684931; Tbc1d31.
DR VEuPathDB; HostDB:ENSMUSG00000022364; -.
DR eggNOG; KOG0295; Eukaryota.
DR eggNOG; KOG1093; Eukaryota.
DR GeneTree; ENSGT00940000153859; -.
DR HOGENOM; CLU_003330_0_0_1; -.
DR InParanoid; Q6NXY1; -.
DR OMA; WFEYHPL; -.
DR OrthoDB; 858041at2759; -.
DR PhylomeDB; Q6NXY1; -.
DR TreeFam; TF324799; -.
DR BioGRID-ORCS; 210544; 7 hits in 74 CRISPR screens.
DR PRO; PR:Q6NXY1; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q6NXY1; protein.
DR Bgee; ENSMUSG00000022364; Expressed in spermatid and 185 other tissues.
DR ExpressionAtlas; Q6NXY1; baseline and differential.
DR Genevisible; Q6NXY1; MM.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF47923; SSF47923; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..996
FT /note="TBC1 domain family member 31"
FT /id="PRO_0000051421"
FT REPEAT 33..74
FT /note="WD 1"
FT REPEAT 75..116
FT /note="WD 2"
FT REPEAT 117..157
FT /note="WD 3"
FT REPEAT 158..200
FT /note="WD 4"
FT REPEAT 201..248
FT /note="WD 5"
FT REPEAT 249..296
FT /note="WD 6"
FT REPEAT 297..334
FT /note="WD 7"
FT DOMAIN 424..599
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT COILED 388..414
FT /evidence="ECO:0000255"
FT COILED 699..844
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..121
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_016185"
FT VAR_SEQ 758..766
FT /note="LAAVKRELE -> CGPHDPAKT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_016186"
FT VAR_SEQ 767..996
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_016187"
FT CONFLICT 55
FT /note="D -> N (in Ref. 2; AAH50039)"
FT /evidence="ECO:0000305"
FT CONFLICT 197
FT /note="C -> R (in Ref. 2; AAH50039)"
FT /evidence="ECO:0000305"
FT CONFLICT 400
FT /note="E -> G (in Ref. 1; BAE32475)"
FT /evidence="ECO:0000305"
FT CONFLICT 806
FT /note="R -> G (in Ref. 2; AAH50039)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 996 AA; 115838 MW; D7AD620F12F9A2B1 CRC64;
MQSTDLGNKE SGKIWHRKPS PATHDGIIVN IVHSTSEYHP KVLRFLNVAF DGSGDSFIAG
DHQGNIYVFD LHGNRFNLVQ RTAQACTALA FNLRRKSEFL VALADYSIKC FDTVTKELVS
WMRGHESSVC SISVHASGRY AITTSSDTAQ LWDLDTFQRK RKLNIRQSVG IQKVFFLPLS
NTILSCFKDN SIFAWECDTL FCKYQLPGPP EGSNILYKVF AVTRDGRILA AGGKSNHLHL
WCLEATGLFR IIQMPAKVRA VRHLEFLPDS FDAGSNQVLG VLSQDGIMRF VNIQTCKLLF
EIGTVEEGIS SSVISPHGRY IASIMENGSL NVYSVQALTQ EINKPPPPLV KVIEDLPSNT
VSSSNLKMKI MPGRVQRPAR CKESKIPTRV LKQDLTGDLE NKENELSEGL NKKRLQILLK
GYGEYPTKYR MFIWRSLLQL PENHTAFSSL VDKGTHAAYL SLQKKYPIKS RKLLRVLQRT
LSALAHWSAI FSDTPYLPLL AFPFVKLFQN NQLICFEVVA TLIINWCQHW FEYFPNPPIN
ILSMIENVLA FHDKELLQHF IDRDITSQVY AWPLLETLFS EVLTREEWLR LFDNIFSNHP
SFLLMTVVAY STCSRAPLLN CTLKNDFEYF FHHRNNLDIN VVIREVYHLM ETTPADIHPN
SMLDAFVALT KGQYPIFNQY PKFIVDYQTR EWERIRNDEL DFLRERQTVE NMQAEVDEQR
AKDEAWYQKQ ELLRRAEETR REILLQEEEK MAQQRQRLAA VKRELEIKEI HLQDAARRRL
LKLQQDQREM ELRRLEDEIE RKVQMRDQEI AATAKDLEIR QLELEAQKRL YEKDLTTSQE
AVAKEIREDT DAHRRKAALE EHMFQKLLEN SQMGGRRAQR WKEAEEKEFH LQSAKKASAL
SDASRKWFLR QETSAALEHE EMPWLQRQYM DSAYLPQTSR LHDVSDMDPS THIFSRNYPT
EWNHMEHDLL KNVRDLRRRL TARARNSCRH PHLLVT
