ID   TBC31_PONAB             Reviewed;         944 AA.
AC   Q5RD21;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=TBC1 domain family member 31;
DE   AltName: Full=WD repeat-containing protein 67;
GN   Name=TBC1D31; Synonyms=WDR67;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CR858097; CAH90336.1; -; mRNA.
DR   RefSeq; NP_001125159.1; NM_001131687.1.
DR   AlphaFoldDB; Q5RD21; -.
DR   SMR; Q5RD21; -.
DR   STRING; 9601.ENSPPYP00000021334; -.
DR   GeneID; 100172046; -.
DR   KEGG; pon:100172046; -.
DR   CTD; 93594; -.
DR   eggNOG; KOG0295; Eukaryota.
DR   eggNOG; KOG1093; Eukaryota.
DR   InParanoid; Q5RD21; -.
DR   Proteomes; UP000001595; Unplaced.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF47923; SSF47923; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..944
FT                   /note="TBC1 domain family member 31"
FT                   /id="PRO_0000051422"
FT   REPEAT          12..52
FT                   /note="WD 1"
FT   REPEAT          53..95
FT                   /note="WD 2"
FT   REPEAT          96..143
FT                   /note="WD 3"
FT   REPEAT          144..191
FT                   /note="WD 4"
FT   REPEAT          192..229
FT                   /note="WD 5"
FT   DOMAIN          300..476
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          262..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          865..900
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          605..735
FT                   /evidence="ECO:0000255"
FT   COILED          791..825
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        263..279
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        877..900
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   944 AA;  110150 MW;  38585E5540ED2385 CRC64;
     MFLTCMETVT KELVSWMRGH ESSVFSISVH ASGKYAITTS SDTAQLWDLD TFQRKRRLNI
     RQSVGIQKVF FLPLSNTILS CFKDNSIFAW ECDTLFCKYQ LPAPPESSSI LYKVFAVTRD
     GRILAAGGKS NHLHLWCLEA RQLFRIIQMP TKVRAIRHLE FLPDSFDAGS NQVLGVLSQD
     GIMRFINIQT CKLLFEIGSL DEGISSSAIS PHGRYIASIM EDGSLNIYSV QALTQEVNKP
     PPPLVKVIED LPKNKLSSSD LKRKVTSGRV QQPAKSRESK IQTRILKQDL TGDFESKKNE
     LPDGLNKERL QILLKGYGEY PTKYSTLIDK GTHVAFLNLQ KKYPIKSRKL LRVLQRTLSA
     LAHWSVIFSD TPYLPLLAFP FVKLFQNNQL ICFEVIATLI INWCQHWFEY FPNPPINILS
     MIENVLAFHD TELLQHFIDH DITSQLYAWP LLETVFSEVL TREEWLKLFD NIFSNHPSFL
     LMTVVAYNMC SRVPLLNCNL KDDFEFFFHH RNNLDINVVI RQVYHLMETT PTDIHPDSML
     NVFVALTKGQ HPVFNQYPKF IVDYQTQERE RIGNDELDYL RERQTVEDMQ AKVDQQRVED
     EAWYQKQELL RKAEETRREM LLQEEEKMIQ QRQRLAAVKR ELKVKEMHLQ DAARRRFLKL
     QQDQQEMELR RLDDEIGRKV YMRDREIAAT ARELEMRQLE LESQKRLYEK NLTENQEAVA
     KEMRADADAY RQKVDLEEHM FHKLIEAGET QSQKTQKVIK ENLAKAEQAC LNTDWQIQSL
     HKQKCDDLQR NKCYQEVAKL LRENRRKEIE IINAMVEEEA KKWKEAEGKE FCLRSAKKAS
     ALSDASRKWF LKQEINAAVE HAENPCHKEE PRFQNEQEDS SCLPRTSQLN DSSEMDPSTQ
     ISLNRRAVEW DTTGQYLIKK VRNLRQRLAA QARHRCQTAH LLAA