ID   TBC31_XENLA             Reviewed;        1089 AA.
AC   Q6DDI6;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=TBC1 domain family member 31;
DE   AltName: Full=WD repeat-containing protein 67;
GN   Name=tbc1d31; Synonyms=wdr67;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC077576; AAH77576.1; -; mRNA.
DR   RefSeq; NP_001086865.1; NM_001093396.1.
DR   AlphaFoldDB; Q6DDI6; -.
DR   SMR; Q6DDI6; -.
DR   PRIDE; Q6DDI6; -.
DR   DNASU; 446700; -.
DR   GeneID; 446700; -.
DR   KEGG; xla:446700; -.
DR   CTD; 446700; -.
DR   Xenbase; XB-GENE-969771; tbc1d31.L.
DR   OrthoDB; 858041at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 446700; Expressed in egg cell and 19 other tissues.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF47923; SSF47923; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1089
FT                   /note="TBC1 domain family member 31"
FT                   /id="PRO_0000051423"
FT   REPEAT          33..74
FT                   /note="WD 1"
FT   REPEAT          75..116
FT                   /note="WD 2"
FT   REPEAT          117..157
FT                   /note="WD 3"
FT   REPEAT          158..200
FT                   /note="WD 4"
FT   REPEAT          201..248
FT                   /note="WD 5"
FT   REPEAT          249..296
FT                   /note="WD 6"
FT   REPEAT          297..334
FT                   /note="WD 7"
FT   DOMAIN          432..607
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          355..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          698..852
FT                   /evidence="ECO:0000255"
FT   COILED          892..951
FT                   /evidence="ECO:0000255"
FT   COILED          1050..1077
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        365..379
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1089 AA;  126825 MW;  BD13E710A1AA7BA2 CRC64;
     MQTTDLGNKE YGKIWHRKPS PSTNEGIIVN IVHVDASHLS KSTRFLQAAF DSAGDCFLAG
     DHLGNVYMFN LNRNRFDLVQ KTMQACTAIA FNLHRKTEFL VALADNSVKC FDAGAKELVS
     WMRGHESAVT SISIHASGRY AVTTSSDTAQ LWDLDTFQRK RKLNVRQSVG IQKVFFLPLS
     NTILSCFKDD SIFAWESDTL ACKYQLPIPE DETKLHYKAF AITRDGRMLA AGGKSKNLHL
     WCLDSKQLFR IIQMPAKVRS VQQLEFLPDN FDGGSSQILG VLSQDGIMRF INIQTCKLVF
     DIGNPDNRVV TSSVSPNGRY ITSVMENGSL NIYSVQALSK ELNKPPPPLV KMVDLSKDKD
     STGNKSGVSR ASQEKVRVSS GRTCRPWKTK DPIVRTKYLR PEDTTASEDK ENALPAGLNK
     PRLQAMLKGF GEYPAKYRMF IWRSLLQLPE NHAAFSSLLD KGTHSQYKLL HQEYPIKSRK
     LLRVLQRTLS ALAHWSAIFG ETKYLPLLAF PFVKLFQNNQ LICFEVVATV ITNWCQHWFE
     YFPNPPINIL GMVENLLAHH DKELLQHFIN HGVNSQVYAW PILETLFSEV LTREEWLRLF
     DNVFSNHPSF LLMAVVSYII SSRSPLLHCN QKDDFEYFFH HRNNLDISNM IREAYHLMDT
     SPAEIHPQRL LSDFEPLTRG QYPIFNKYPK FIVDYQGQER ERIRQEEMEY LRERQLTQEV
     EAEAVKRRLE DQAWYQQQEL LKGAEEQRRK LLMDEEQKLL HQRQRLATVK RELRLKELQL
     LDAARRRFLR YQQDQRKMEL RRLDDEIERK VSLREQETAT IVKDVEIRQM ELEAQRRFFE
     QQLAKEQEAV TQDMKGELDA NRRRADLEEQ MFWRLMETEE DLKDQKLLEE SLAKAERLCV
     ETDWKIQSLQ KQKCDDWERG KRYEEISKLT EDVQEKEREL CNVLKDMETR KWAEVSQKMT
     ELEREKLAGS AQQAQRQQFL QEKLRQEAGP IDISGEDGNE YFERLRDLNR SSMQKDFSSS
     DEQHVPENVC LNDVSASDSS THFSLDRGRG ELERGERALI SEVRELRQKL ASQAHKKYPH
     LHFSQTSWS