ID   TBC31_XENTR             Reviewed;        1088 AA.
AC   Q6DEY8;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=TBC1 domain family member 31;
DE   AltName: Full=WD repeat-containing protein 67;
GN   Name=tbc1d31; Synonyms=wdr67;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; BC076955; AAH76955.1; -; mRNA.
DR   RefSeq; NP_001005061.1; NM_001005061.1.
DR   AlphaFoldDB; Q6DEY8; -.
DR   SMR; Q6DEY8; -.
DR   STRING; 8364.ENSXETP00000050138; -.
DR   PaxDb; Q6DEY8; -.
DR   PRIDE; Q6DEY8; -.
DR   GeneID; 448614; -.
DR   KEGG; xtr:448614; -.
DR   CTD; 93594; -.
DR   Xenbase; XB-GENE-969766; tbc1d31.
DR   eggNOG; KOG0295; Eukaryota.
DR   eggNOG; KOG1093; Eukaryota.
DR   InParanoid; Q6DEY8; -.
DR   OrthoDB; 858041at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF47923; SSF47923; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1088
FT                   /note="TBC1 domain family member 31"
FT                   /id="PRO_0000051424"
FT   REPEAT          33..74
FT                   /note="WD 1"
FT   REPEAT          75..116
FT                   /note="WD 2"
FT   REPEAT          117..157
FT                   /note="WD 3"
FT   REPEAT          158..200
FT                   /note="WD 4"
FT   REPEAT          201..248
FT                   /note="WD 5"
FT   REPEAT          249..296
FT                   /note="WD 6"
FT   REPEAT          297..334
FT                   /note="WD 7"
FT   DOMAIN          432..607
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          356..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          736..903
FT                   /evidence="ECO:0000255"
FT   COILED          1048..1076
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        362..379
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1088 AA;  126647 MW;  A11FD2957EAE101D CRC64;
     MQTTDLGNKE SGKIWHRKPN PSTNEGIIVN IVHVDASHPS KSARFLHAGF DSAGDSFIAG
     DHLGNVYLFN LNRNRFDLVQ KTMQACTAIA FNLHRRTEFL VALADNSVKC FDTGAKELVS
     WMRGHESAVT SISVHPSGRY AVTTSSDTAQ LWDLDTFQRK RKLNVRQSVG IQKVFFLPLS
     NTILSCFKDD SIFAWESDTL ACKYQLPIPE DGTKLRYKAF AITRDGRMLA AGGKSNNLHL
     WCLDSKQLFR IIQMPTKVRS VQQLEFLPEN FDGGSSQILG VLSQDGIMRF INIQTCKLVF
     DIGSHDNGIV TSSVSPNGRY ITSVMENGSL NIYSVQALSK ELNKPPPPLV KMVDLSKDKD
     STGNKSGVSG ASQEKVRVSS GRTCRPWKSK DQIVRTKYLR PEDTTTSEDK ENTLPAGLSK
     QRLQALLKGF GEYPAKYRMF IWRSLLQLPE NHAAFSSLLD KGTHTQYKLL HQEYPIKSRK
     LLRVLQRTLS ALAHWSAIFG ETKYLPLLAF PFVKLFQNNQ LICFEVVATV ITNWCQHWFE
     YFPNPPINIL GMVENLLAHH DKELLQHFIN YGVTSQVYAW PLLETLFSEV LTREEWLRLF
     DNVFSNHPSF LLMAVVSYII SSRSPLLHCN QKDDFEYFFH HRNNLDIGNM IREAYHLMDT
     SPAEIHPRRL LSDFEPLTRG QYPIFNKYPK FIVDYQGQER ERIRQEEIEY LRERQLTHKV
     EAEAVKRRLE DEAWYQQQEL LKGAEEQRRK LLMDEEQKLL HQRQRLATVK RELRLKELQL
     LDAARRRFLR YQQDQRKMEL RRLDDELERK MSLRERETAT IAKDVEIRQM ELEAQRRFFE
     QQLAKEQEAV TQEVKGEMDA NRRRADLEEQ MFWRLMETEE DLKDKKLLEE SLAKAERLCV
     ETDWKIQTLQ KQKCDDQERG KRYVEVSKMT DDVREKEREL CDVLKAMETR KWAEVSEKMT
     QLETEELASS ALRAKRNQFL QERLRQEAEP VNISEDGNEY FERLRDLSRN STQNDFSSSA
     ERHVAENVCL NDVSASDSST HFSLDRGRGE LENRERALIS EVRELRQKLA TQARRKYPQL
     HFSETNWT