TBC5A_DICDI
ID TBC5A_DICDI Reviewed; 1173 AA.
AC Q54VM3;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=TBC1 domain family member 5 homolog A;
GN Name=tbc1d5A; ORFNames=DDB_G0280253;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP PROTEIN SEQUENCE OF 331-347; 358-368 AND 937-945, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC STRAIN=AX2;
RA Bienvenut W.V., Sumpton D., Ura S., Insall R.H.;
RL Submitted (OCT-2008) to UniProtKB.
CC -!- FUNCTION: May act as a GTPase-activating protein for Rab family
CC protein(s). {ECO:0000250}.
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DR EMBL; AAFI02000035; EAL67353.1; -; Genomic_DNA.
DR RefSeq; XP_641332.1; XM_636240.1.
DR AlphaFoldDB; Q54VM3; -.
DR STRING; 44689.DDB0235314; -.
DR PaxDb; Q54VM3; -.
DR EnsemblProtists; EAL67353; EAL67353; DDB_G0280253.
DR GeneID; 8622466; -.
DR KEGG; ddi:DDB_G0280253; -.
DR dictyBase; DDB_G0280253; -.
DR eggNOG; KOG1091; Eukaryota.
DR HOGENOM; CLU_273905_0_0_1; -.
DR InParanoid; Q54VM3; -.
DR OMA; SLRWIRI; -.
DR PRO; PR:Q54VM3; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR Pfam; PF00566; RabGAP-TBC; 2.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47923; SSF47923; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Direct protein sequencing; GTPase activation;
KW Reference proteome.
FT CHAIN 1..1173
FT /note="TBC1 domain family member 5 homolog A"
FT /id="PRO_0000388363"
FT DOMAIN 374..729
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT REGION 22..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 425..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 983..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1054..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 163..214
FT /evidence="ECO:0000255"
FT COILED 885..930
FT /evidence="ECO:0000255"
FT COMPBIAS 217..294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 136362 MW; 678D64A6159BE2F5 CRC64;
MEDNDISFSI FGNSDDILDN TKKSKSNINN SGSSIFGNGN ENNNNMNTNN NNSNQNNNDI
NYNNNNNNNN NNNSNNSNNS NNNNNNINNN NNRNNNNFNN NNNNNVNYFE QDVDFGENAH
SSNYGDNNNI FSDESNNYNN NNNNNDYNNN NYYDNNNYNE NYNENYNENY NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNY YNENNNQQQL QQNYSNNNYN NEYINNFNNN DNSYNNNNNN
NNNNSNFNNY NNNNNGYDNS YSNSNNNNYY DNSNNNSKND NQYNQQQQYY QEEEQQQQQH
EEFEKEIEQK EQDSSPINVN RNPNNSVMIK IGEVEVPEDI YNQKVEKWRN DFNSIFRNLE
TLEIDYTKAT FGLPKDTTVR SIFWRIALGT LSKDPTTWVE RTNSSRKKYE TFKKNYIINP
RNSKDQDADL QQQQQQQQQQ QRKPVSLIDD PLSQSEDSLW NQFFDNENAQ REISHDISRT
YPGLGFFERL DIQDIMIRIL FIFSKQYPKI KYLQGMNEIL APILYSVYND SHWFNNRDVF
SKKNYDKKNK QYEHFDFVFD QQYQQDYYPD GPIQYPTNSN NFNGAGSSGS GGSVSRKDGG
IGAFLRDPQY FEHDSYFIFE SLMTIVGKWF TSPPSSPQPP PRVQGQFKKL YDLSERDASD
QAVNIVVVDQ CLRMFEDLKF IEPQLYSYLK QDLGIEPHLY SLRWIRIILA QVFPLDSLLI
LWDSIFKESV TEFLPYICLT MLIMIKDQII EKDYSECLQV LFHYPVTQDM PMLLNTAYSV
REKIQMAKQQ YNIPISTPVS TPLPTSLSRR SIKAYPVSTS STIVNQSTTT NSSSSSTTTS
TTSANRGLSH SSQSYRSSSG SGSGSISNQN KGNGQSGIFS SFTSTFKQII NDLNEYNEEF
QLAKENEQLK QQKSKLQKEV DTLKETQTHV ISRLERILFS FVDFKQKHIH DQDNFESVDA
MEKEVTSILN EVLNSQTTIA NLNNSKNRLP NKSVQQSTIS QQSTTPQQSI TQQTSSPNIV
LKQQQPITVI SQQQQSQQQQ SLQQEQQQST QQQQSTQQEQ QSTQQEQQQS TQPQQSQQNN
DNSPFQQYNN DNRQEKISLE DEVFFDNQFV SVQSTNKEFQ LKTLSLPNVE IHEDDLVEVK
THDSTVDEDE DGNPITEQYN YKQQLEARWG FNK
