TBC5B_DICDI
ID TBC5B_DICDI Reviewed; 1016 AA.
AC Q54TA5;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=TBC1 domain family member 5 homolog B;
GN Name=tbc1d5B; ORFNames=DDB_G0281891;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May act as a GTPase-activating protein for Rab family
CC protein(s). {ECO:0000250}.
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DR EMBL; AAFI02000043; EAL66505.1; -; Genomic_DNA.
DR RefSeq; XP_640484.1; XM_635392.1.
DR AlphaFoldDB; Q54TA5; -.
DR SMR; Q54TA5; -.
DR STRING; 44689.DDB0235326; -.
DR PaxDb; Q54TA5; -.
DR EnsemblProtists; EAL66505; EAL66505; DDB_G0281891.
DR GeneID; 8623298; -.
DR KEGG; ddi:DDB_G0281891; -.
DR dictyBase; DDB_G0281891; rbg3.
DR eggNOG; KOG1091; Eukaryota.
DR HOGENOM; CLU_296919_0_0_1; -.
DR InParanoid; Q54TA5; -.
DR OMA; GLAWRIF; -.
DR PRO; PR:Q54TA5; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0031252; C:cell leading edge; IDA:dictyBase.
DR GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IMP:dictyBase.
DR GO; GO:1903665; P:negative regulation of asexual reproduction; IMP:dictyBase.
DR GO; GO:0031156; P:regulation of sorocarp development; IMP:dictyBase.
DR GO; GO:0031000; P:response to caffeine; IMP:dictyBase.
DR InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR Pfam; PF00566; RabGAP-TBC; 2.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47923; SSF47923; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW GTPase activation; Reference proteome.
FT CHAIN 1..1016
FT /note="TBC1 domain family member 5 homolog B"
FT /id="PRO_0000388364"
FT DOMAIN 280..636
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..547
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1016 AA; 112407 MW; E78F473653A0F4DC CRC64;
MDTSGFLDLD INSGTTTPNI RNSVTTSNDI MSSIFDTIPT KEKKVDAAVE SIFGTEAANS
PLISSSIPPI PIEASTSTQQ QQQQQQQQEE IIPSQPISVT KENTVTTTTT TTATTAVPTT
TTTPTSTLIN SEPIVVNPLE VNINTKVDDS DSDQDEQIKK ENVVHEIFTP IVSIINNNNN
NNNNEIDNNN NGNSNENTTT TTTNKDMNNS FSMGVTTASK DEHIISTTTV GTIEQEIHEK
QEEPLISPLQ SEFNKIFFST IPLEKKPLEI LKMNAFTGAL KYSPLRGIAW KLFLGGLDIN
RVDKWERDIT QQRKRYEKLK EEHCFDPRNS NSTYDPLSQN DDSPWNKFFK NLDTQKIIKI
DLERTHPDND FFSNPVIREM MATILFVYSK TNGIISYRQG MHELLAPIIY LYNQEYSSYK
KLDENSSSTL VDFIYNIKYL EHDTFAIFER LMKFTSDWYA PAPTQQTNNS NNSNNTNNNN
TTTSPSSSSS SSSSSTTTAA ATTVSSSTST SSSSSTITSS SSSTVSPPPP SSSSSPSPPP
PPPLGSNSPT VASSSSSSVQ DNEEEELSSK CNDVVLKCKY IHSILLKQKD FELYQHLDSL
DIEPQIYLLR WIRLLFGREF HFDDVLNIWD ALFAYGENLI LIDYFCISML TYIREHLLKS
DSIYALKRIY KYPPVEDVYM LIKKALEIKD SNCSIAGMVK TAQPPTTLSS SGSRQIPNNN
NNNNNNNNNN NNNNNNNNNS NNNINNNNNN SNNNITTPST QANTLPFPET STFESTTSSF
QPYSSQLSSA NTTPIDPLSN KTTPLISSTS NVSNTPNITS TSTLLSSSSS SSSSTTTPLQ
SHTPILTHNN NNSHFSPSPS SSSSSLNNSS HVSIPVKSNV KDIFANSKES DLFSLFSTAT
TPINNNTSSL SISNPTISIG QARTLNKHKS MTLPSSPLIS QDSEALKQLK NTQIEFGNQL
KEVLPFLEKG KNFLLGNEDE LSKSEIDDFI KALEKVKQIQ EILSNNNINN NNENKL
