ID   TBCA_DICDI              Reviewed;         113 AA.
AC   Q75JC8; Q55AM5;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 3.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Tubulin-specific chaperone A;
DE   AltName: Full=Tubulin-folding cofactor A;
DE            Short=CFA;
GN   Name=tbca; ORFNames=DDB_G0271706;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Tubulin-folding protein; involved in the early step of the
CC       tubulin folding pathway. {ECO:0000250}.
CC   -!- SUBUNIT: Supercomplex made of cofactors A to E. Cofactors A and D
CC       function by capturing and stabilizing tubulin in a quasi-native
CC       conformation. Cofactor E binds to the cofactor D-tubulin complex;
CC       interaction with cofactor C then causes the release of tubulin
CC       polypeptides that are committed to the native state (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TBCA family. {ECO:0000305}.
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DR   EMBL; AAFI02000006; EAL71543.2; -; Genomic_DNA.
DR   RefSeq; XP_645497.2; XM_640405.2.
DR   AlphaFoldDB; Q75JC8; -.
DR   SMR; Q75JC8; -.
DR   BioGRID; 1243128; 1.
DR   PaxDb; Q75JC8; -.
DR   PRIDE; Q75JC8; -.
DR   EnsemblProtists; EAL71543; EAL71543; DDB_G0271706.
DR   GeneID; 8618125; -.
DR   KEGG; ddi:DDB_G0271706; -.
DR   dictyBase; DDB_G0271706; tbcA.
DR   eggNOG; ENOG502SCKC; Eukaryota.
DR   HOGENOM; CLU_130569_1_1_1; -.
DR   InParanoid; Q75JC8; -.
DR   OMA; DDGSEIW; -.
DR   PhylomeDB; Q75JC8; -.
DR   PRO; PR:Q75JC8; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR   GO; GO:0048487; F:beta-tubulin binding; IEA:InterPro.
DR   GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR   GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   GO; GO:0007021; P:tubulin complex assembly; IBA:GO_Central.
DR   InterPro; IPR004226; TBCA.
DR   InterPro; IPR036126; TBCA_sf.
DR   PANTHER; PTHR21500; PTHR21500; 1.
DR   Pfam; PF02970; TBCA; 1.
DR   SUPFAM; SSF46988; SSF46988; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT   CHAIN           1..113
FT                   /note="Tubulin-specific chaperone A"
FT                   /id="PRO_0000330741"
SQ   SEQUENCE   113 AA;  13484 MW;  940B4B4DE828FCA5 CRC64;
     MVLDTKRSLK IKIDALKRLE KDYMLYKKEE QLQIENVERF KADETKDIYD VKKQIEILDE
     NKTMIIDSVS RVTAFLVQFS EFLEEHKNED DGSEIWKDSY DIIDQISTKF LGE