ID   TBCC1_DANRE             Reviewed;         582 AA.
AC   A4QP31; A8WHY2; Q5SQE5;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 3.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=TBCC domain-containing protein 1;
GN   Name=tbccd1; ORFNames=si:ch211-194d6.5, si:rp71-45g20.12, zgc:162789;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the regulation of centrosome and Golgi
CC       apparatus positioning. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TBCC family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL772198; CAI11699.2; -; Genomic_DNA.
DR   EMBL; BX511265; CAP19542.1; -; Genomic_DNA.
DR   EMBL; BC139633; AAI39634.1; -; mRNA.
DR   RefSeq; NP_001038617.2; NM_001045152.2.
DR   AlphaFoldDB; A4QP31; -.
DR   SMR; A4QP31; -.
DR   STRING; 7955.ENSDARP00000064155; -.
DR   PaxDb; A4QP31; -.
DR   PeptideAtlas; A4QP31; -.
DR   GeneID; 100037389; -.
DR   CTD; 55171; -.
DR   ZFIN; ZDB-GENE-041210-222; tbccd1.
DR   eggNOG; KOG4416; Eukaryota.
DR   InParanoid; A4QP31; -.
DR   OrthoDB; 433967at2759; -.
DR   PhylomeDB; A4QP31; -.
DR   TreeFam; TF329418; -.
DR   PRO; PR:A4QP31; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031616; C:spindle pole centrosome; IBA:GO_Central.
DR   GO; GO:0051661; P:maintenance of centrosome location; IBA:GO_Central.
DR   GO; GO:0051684; P:maintenance of Golgi location; IBA:GO_Central.
DR   Gene3D; 2.160.20.70; -; 1.
DR   InterPro; IPR017901; C-CAP_CF_C-like.
DR   InterPro; IPR016098; CAP/MinC_C.
DR   InterPro; IPR006599; CARP_motif.
DR   InterPro; IPR039589; TBCC1.
DR   InterPro; IPR012945; Tubulin-bd_cofactor_C_dom.
DR   PANTHER; PTHR16052; PTHR16052; 1.
DR   Pfam; PF07986; TBCC; 1.
DR   SMART; SM00673; CARP; 1.
DR   PROSITE; PS51329; C_CAP_COFACTOR_C; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..582
FT                   /note="TBCC domain-containing protein 1"
FT                   /id="PRO_0000304948"
FT   DOMAIN          305..451
FT                   /note="C-CAP/cofactor C-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00659"
FT   REGION          140..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          547..582
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        312
FT                   /note="L -> V (in Ref. 1; CAP19542)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        390
FT                   /note="I -> R (in Ref. 2; AAI39634)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        485
FT                   /note="I -> S (in Ref. 1; CAI11699)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        576
FT                   /note="Q -> H (in Ref. 2; AAI39634)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   582 AA;  65778 MW;  CD5B28A8A739E218 CRC64;
     MDKYTAYVWP RLEPFLVGVL PATPPSKFSM HYLRKMASYV RTRDGCFPRL GWQMWRHIAC
     GKLQLAEDLA WLYFETFDLL MPRSAEQRLE WAEALSQCHT QKELDRQRCK LSVDTLQFLL
     FLYLQQLNRI SLRTSLIGEE WPSPRSRSPS SSSSERDAKI SSQNKNWDVQ AHLTFIQTHL
     PELLELLVEP GQLSSSGQVL RDSHLTSEAV ESLSLLLEGS VSHSRTVHPV HKLLSRSQLQ
     SQAGFSKLSC SYSLQQFQDF LRQALCLNPF GISNCSQSGK KLSWALQVEG TLKKAKIFRN
     THAAPPGSRL VLMSQVCKQT LAKDSEKLND VNIKLHRCSE AFIYLLSPLW SVTLDKCRNS
     TLVLGPVRTS VHIQSCENVR VVCVAGRLTI GGSFNCTIHS LTPTRPLLLP GNASLTLGPF
     HTQYPTLEDH MASAGLAVVP NLWNQPLLFG VEGSAPDTGC YRIQPPSEFY PLVIPFQMDG
     DNCEIPCSLP EDFQKALESR EKTIEEWQKT VKDAHLNKAQ RRQFQALVEQ KFHEWLLETG
     QRQELDSLLP PTITPSSSAE HWSSNQNTLK EQTHEQPTGT VC