TBCC1_MOUSE
ID TBCC1_MOUSE Reviewed; 552 AA.
AC Q640P7; Q68FM1; Q8CA17; Q9CYG4;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=TBCC domain-containing protein 1;
GN Name=Tbccd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Embryo, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=20168327; DOI=10.1038/embor.2010.5;
RA Goncalves J., Nolasco S., Nascimento R., Lopez Fanarraga M., Zabala J.C.,
RA Soares H.;
RT "TBCCD1, a new centrosomal protein, is required for centrosome and Golgi
RT apparatus positioning.";
RL EMBO Rep. 11:194-200(2010).
CC -!- FUNCTION: Plays a role in the regulation of centrosome and Golgi
CC apparatus positioning, with consequences on cell shape and cell
CC migration. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole
CC {ECO:0000250}. Note=Localizes at the spindle midzone, midbody and basal
CC bodies of primary and motile cilia. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q640P7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q640P7-2; Sequence=VSP_028139, VSP_028140;
CC -!- TISSUE SPECIFICITY: Expressed in brain and testis (at protein level).
CC {ECO:0000269|PubMed:20168327}.
CC -!- SIMILARITY: Belongs to the TBCC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC30476.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK017705; BAB30885.1; -; mRNA.
DR EMBL; AK039905; BAC30476.1; ALT_FRAME; mRNA.
DR EMBL; AK043059; BAC31450.1; -; mRNA.
DR EMBL; BC079629; AAH79629.1; -; mRNA.
DR EMBL; BC082558; AAH82558.1; -; mRNA.
DR CCDS; CCDS49798.1; -. [Q640P7-1]
DR RefSeq; NP_001074837.1; NM_001081368.2. [Q640P7-1]
DR RefSeq; NP_001303675.1; NM_001316746.1. [Q640P7-1]
DR RefSeq; XP_006522630.1; XM_006522567.3. [Q640P7-1]
DR RefSeq; XP_006522631.1; XM_006522568.3. [Q640P7-1]
DR AlphaFoldDB; Q640P7; -.
DR SMR; Q640P7; -.
DR STRING; 10090.ENSMUSP00000004576; -.
DR iPTMnet; Q640P7; -.
DR PhosphoSitePlus; Q640P7; -.
DR PaxDb; Q640P7; -.
DR PRIDE; Q640P7; -.
DR ProteomicsDB; 263134; -. [Q640P7-1]
DR ProteomicsDB; 263135; -. [Q640P7-2]
DR Antibodypedia; 46838; 76 antibodies from 15 providers.
DR Ensembl; ENSMUST00000004576; ENSMUSP00000004576; ENSMUSG00000004462. [Q640P7-1]
DR Ensembl; ENSMUST00000232075; ENSMUSP00000156210; ENSMUSG00000004462. [Q640P7-1]
DR GeneID; 70573; -.
DR KEGG; mmu:70573; -.
DR UCSC; uc007ysk.1; mouse. [Q640P7-1]
DR UCSC; uc007ysm.1; mouse. [Q640P7-2]
DR CTD; 55171; -.
DR MGI; MGI:1917823; Tbccd1.
DR VEuPathDB; HostDB:ENSMUSG00000004462; -.
DR eggNOG; KOG4416; Eukaryota.
DR GeneTree; ENSGT00470000042284; -.
DR HOGENOM; CLU_016712_1_1_1; -.
DR InParanoid; Q640P7; -.
DR OMA; SMHYLRK; -.
DR OrthoDB; 433967at2759; -.
DR PhylomeDB; Q640P7; -.
DR TreeFam; TF329418; -.
DR BioGRID-ORCS; 70573; 0 hits in 70 CRISPR screens.
DR ChiTaRS; Tbccd1; mouse.
DR PRO; PR:Q640P7; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q640P7; protein.
DR Bgee; ENSMUSG00000004462; Expressed in spermatocyte and 226 other tissues.
DR ExpressionAtlas; Q640P7; baseline and differential.
DR Genevisible; Q640P7; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0031616; C:spindle pole centrosome; ISS:UniProtKB.
DR GO; GO:0051661; P:maintenance of centrosome location; ISS:UniProtKB.
DR GO; GO:0051684; P:maintenance of Golgi location; ISS:UniProtKB.
DR GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
DR Gene3D; 2.160.20.70; -; 1.
DR InterPro; IPR017901; C-CAP_CF_C-like.
DR InterPro; IPR016098; CAP/MinC_C.
DR InterPro; IPR036223; CAP_C_sf.
DR InterPro; IPR006599; CARP_motif.
DR InterPro; IPR039589; TBCC1.
DR InterPro; IPR012945; Tubulin-bd_cofactor_C_dom.
DR PANTHER; PTHR16052; PTHR16052; 1.
DR Pfam; PF07986; TBCC; 1.
DR SMART; SM00673; CARP; 2.
DR SUPFAM; SSF69340; SSF69340; 1.
DR PROSITE; PS51329; C_CAP_COFACTOR_C; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..552
FT /note="TBCC domain-containing protein 1"
FT /id="PRO_0000304945"
FT DOMAIN 304..435
FT /note="C-CAP/cofactor C-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00659"
FT VAR_SEQ 287..288
FT /note="VE -> GI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028139"
FT VAR_SEQ 289..552
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_028140"
FT CONFLICT 6..7
FT /note="VL -> AS (in Ref. 1; BAC30476)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 552 AA; 62848 MW; A3E5EAAC0224E7ED CRC64;
MDQSGVLLWV KAEPFLVGAL QEPPPSKFSL HYLRKIATYV RTRATEGAYP HLYWPTWRHI
ACGKLQLAKD LAWLYFEMFD NLSVRTPEER LEWSEILSNC ATEEEVEKQR SQLYVDTLQF
LLFLYIQQLN RISLRTSLIG EEWPSRRSRP QSPSPAERPS CHNKNWNDYS HQAFVCNHLS
ELLELLLDPE QLTASFHSTH SSLLSRDAVT ALSFLIEGTV SRAKKVYPLH QLALWQPLHV
ASGFSKSSKT FSLYKLEAWL RASLTTNPFG PSACLKSGKK LAWAHQVEGS TKRAKIACNA
HMAPRLHRIV VMSQVYKQTL AKSSETLVGA HVRAHRCSES FIYLLSPLRS MTIEKCRNST
FVLGPVETTL HLHDCENLKV IAVCHRLSIS STTSCTFHIM TPSRPLILSG NQTVTFAPFH
THYPMLEDHM ARTGLATVPN YWDNPMVVCK EGSVTSLFRL LPPSEFYIFV IPFEMEGDTA
EIPGGLPSAY QKALAQREES IHIWQKTVKE ARLTKEQRKQ FQALVENKFY EWLVSTGHRQ
QLDSLVPTPA AS
