ID   TBCC1_RAT               Reviewed;         569 AA.
AC   Q5FVR8;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=TBCC domain-containing protein 1;
GN   Name=Tbccd1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in the regulation of centrosome and Golgi
CC       apparatus positioning, with consequences on cell shape and cell
CC       migration. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250}. Note=Localizes at the spindle midzone, midbody and basal
CC       bodies of primary and motile cilia. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TBCC family. {ECO:0000305}.
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DR   EMBL; BC089823; AAH89823.1; -; mRNA.
DR   RefSeq; NP_001012016.1; NM_001012016.1.
DR   RefSeq; XP_006248608.1; XM_006248546.3.
DR   AlphaFoldDB; Q5FVR8; -.
DR   SMR; Q5FVR8; -.
DR   STRING; 10116.ENSRNOP00000036828; -.
DR   PhosphoSitePlus; Q5FVR8; -.
DR   PaxDb; Q5FVR8; -.
DR   PRIDE; Q5FVR8; -.
DR   Ensembl; ENSRNOT00000111940; ENSRNOP00000088290; ENSRNOG00000026458.
DR   GeneID; 303830; -.
DR   KEGG; rno:303830; -.
DR   UCSC; RGD:1309604; rat.
DR   CTD; 55171; -.
DR   RGD; 1309604; Tbccd1.
DR   eggNOG; KOG4416; Eukaryota.
DR   GeneTree; ENSGT00470000042284; -.
DR   InParanoid; Q5FVR8; -.
DR   OMA; SMHYLRK; -.
DR   OrthoDB; 433967at2759; -.
DR   PhylomeDB; Q5FVR8; -.
DR   TreeFam; TF329418; -.
DR   PRO; PR:Q5FVR8; -.
DR   Proteomes; UP000002494; Chromosome 11.
DR   Bgee; ENSRNOG00000026458; Expressed in testis and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031616; C:spindle pole centrosome; ISS:UniProtKB.
DR   GO; GO:0051661; P:maintenance of centrosome location; ISS:UniProtKB.
DR   GO; GO:0051684; P:maintenance of Golgi location; ISS:UniProtKB.
DR   GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
DR   Gene3D; 2.160.20.70; -; 1.
DR   InterPro; IPR017901; C-CAP_CF_C-like.
DR   InterPro; IPR016098; CAP/MinC_C.
DR   InterPro; IPR006599; CARP_motif.
DR   InterPro; IPR039589; TBCC1.
DR   InterPro; IPR012945; Tubulin-bd_cofactor_C_dom.
DR   PANTHER; PTHR16052; PTHR16052; 1.
DR   Pfam; PF07986; TBCC; 1.
DR   SMART; SM00673; CARP; 2.
DR   PROSITE; PS51329; C_CAP_COFACTOR_C; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..569
FT                   /note="TBCC domain-containing protein 1"
FT                   /id="PRO_0000304946"
FT   DOMAIN          304..435
FT                   /note="C-CAP/cofactor C-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00659"
SQ   SEQUENCE   569 AA;  64693 MW;  A8552C503BBEA3DD CRC64;
     MDQSGVLLWV KAEPFIVGAL QEPPPSKLSL HYLKKVAAYV RTRATERAYP RLYWPTWRHI
     ACGKLQLAKD LAWLYFEIFD NLSERTPEER LEWSEILSNC TTKDEVEKQR NQLSVDTLQF
     LLFLYIQQLN KISLRTSFIG EEWPSPRNRP KSPSPAERSS CHNKNWNDYN HQAFVCDHLS
     ELLELLLDPE QLTESFHSTQ SSLLSREAVT ALSFLIEGTV SRTKKVYPLH ELALWQPLHA
     ANGFSKISKT FSLYKLEAWL RACLTTNPFG LSACLQSGKK LAWAHKVEGA TKRAKIACNA
     HMAPRSHRIV VMSQVCNQTL AKSSETLVGA HVRAHRCNES FIYLLSPLRS MTIEKCRNST
     FVLGPVETAL HLHGCENLKV IAVCHRLSVS STIGCTFHIM TPSRPLILSG NQTVTFAPFH
     THYPMLEDHM ARTGLATVPN YWDDPMVLGG EGTDTRVFQL LPPSEFYVFV TPFEMEGDTA
     EIPGGLPPAY QKALAHREQR IHNWQKTVKE ARLTKEQRKQ FQVLVENKFY EWLVSTGHRQ
     QLDSLVPPPA ASNQVAKKDL TWSHGALET