ID   TBCC1_XENTR             Reviewed;         547 AA.
AC   A1L0Z4; Q28GJ9;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=TBCC domain-containing protein 1;
GN   Name=tbccd1; ORFNames=TEgg114l12.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the regulation of centrosome and Golgi
CC       apparatus positioning. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A1L0Z4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A1L0Z4-2; Sequence=VSP_028141, VSP_028142;
CC   -!- SIMILARITY: Belongs to the TBCC family. {ECO:0000305}.
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DR   EMBL; CR761361; CAJ81373.1; -; mRNA.
DR   EMBL; BC127345; AAI27346.1; -; mRNA.
DR   RefSeq; NP_001016961.2; NM_001016961.3. [A1L0Z4-1]
DR   AlphaFoldDB; A1L0Z4; -.
DR   SMR; A1L0Z4; -.
DR   STRING; 8364.ENSXETP00000053835; -.
DR   PaxDb; A1L0Z4; -.
DR   Ensembl; ENSXETT00000053835; ENSXETP00000053835; ENSXETG00000013351.
DR   GeneID; 549715; -.
DR   KEGG; xtr:549715; -.
DR   CTD; 55171; -.
DR   Xenbase; XB-GENE-5736157; tbccd1.
DR   eggNOG; KOG4416; Eukaryota.
DR   HOGENOM; CLU_016712_1_1_1; -.
DR   InParanoid; A1L0Z4; -.
DR   OMA; SMHYLRK; -.
DR   OrthoDB; 433967at2759; -.
DR   PhylomeDB; A1L0Z4; -.
DR   TreeFam; TF329418; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000013351; Expressed in egg cell and 12 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0031616; C:spindle pole centrosome; IBA:GO_Central.
DR   GO; GO:0051661; P:maintenance of centrosome location; IBA:GO_Central.
DR   GO; GO:0051684; P:maintenance of Golgi location; IBA:GO_Central.
DR   Gene3D; 2.160.20.70; -; 1.
DR   InterPro; IPR017901; C-CAP_CF_C-like.
DR   InterPro; IPR016098; CAP/MinC_C.
DR   InterPro; IPR036223; CAP_C_sf.
DR   InterPro; IPR006599; CARP_motif.
DR   InterPro; IPR039589; TBCC1.
DR   InterPro; IPR012945; Tubulin-bd_cofactor_C_dom.
DR   PANTHER; PTHR16052; PTHR16052; 1.
DR   Pfam; PF07986; TBCC; 1.
DR   SMART; SM00673; CARP; 2.
DR   SUPFAM; SSF69340; SSF69340; 1.
DR   PROSITE; PS51329; C_CAP_COFACTOR_C; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..547
FT                   /note="TBCC domain-containing protein 1"
FT                   /id="PRO_0000304950"
FT   DOMAIN          304..435
FT                   /note="C-CAP/cofactor C-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00659"
FT   VAR_SEQ         287..302
FT                   /note="VDGLNKRAKVACNTYK -> GQTTVFYGELCPHVCM (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_028141"
FT   VAR_SEQ         303..547
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_028142"
SQ   SEQUENCE   547 AA;  62766 MW;  026C9996FF81DC72 CRC64;
     MDDSRVQLWV KTDPFLLGAL QIPPPEKFSM HYLRKMATYV RTRASEGCYP RLCWCMWRHI
     ACGKLQILEE TAWLYFETFL SVFERSVAES LNWAEVASTC PSSEKYEEVK SKLSVDTLKF
     MLFLYIQQIN KISLRSPLIG NEWPSPRGRS PISDFAAQSS FYNKVWDDYS HYNFIHNHLT
     YILELLMEPN QLSKVSQFSH CILISAEVVT ALGFVIEGTV DKNRVVNAFL DLAIWQPVQI
     KSGFIETLGS FSFQKLQAWI KECLVINPFG ITSCIKSGTK LSWAQQVDGL NKRAKVACNT
     YKVPHTHRMV VMSQISKQTL AKSSKTLVDA RVKIHRCSDC YIYLLSPLRS VTVEKCQNCT
     IVLGPVQTVL HIQMCYNVKI IAVCQRLSLL STTNCTFHVL TPTRPLFYCG NQGVVLAPFH
     ISYSMLEDHM AHTGLATVPN SWDRPFFFST ESSNSHIWRL LLPEEFFTFV VPFEMEGDTT
     EIPGGLPPAY STSVQQRQQK IRMWQETVKD AGLTREQRKQ LQAVVEMKFN EWLIKTENRH
     QLDSLVS