ID   TBCC_SCHPO              Reviewed;         259 AA.
AC   Q9P3T8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Tubulin-specific chaperone C;
DE   AltName: Full=Tubulin-folding cofactor C;
DE            Short=CFC;
GN   Name=cin2; ORFNames=SPAC328.08c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Tubulin-folding protein; involved in the final step of the
CC       tubulin folding pathway. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TBCC family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB96003.1; -; Genomic_DNA.
DR   RefSeq; NP_594210.1; NM_001019633.2.
DR   AlphaFoldDB; Q9P3T8; -.
DR   SMR; Q9P3T8; -.
DR   BioGRID; 279617; 6.
DR   STRING; 4896.SPAC328.08c.1; -.
DR   MaxQB; Q9P3T8; -.
DR   PaxDb; Q9P3T8; -.
DR   EnsemblFungi; SPAC328.08c.1; SPAC328.08c.1:pep; SPAC328.08c.
DR   GeneID; 2543188; -.
DR   KEGG; spo:SPAC328.08c; -.
DR   PomBase; SPAC328.08c; -.
DR   VEuPathDB; FungiDB:SPAC328.08c; -.
DR   eggNOG; KOG2512; Eukaryota.
DR   HOGENOM; CLU_1094821_0_0_1; -.
DR   InParanoid; Q9P3T8; -.
DR   OMA; HQFRLHE; -.
DR   PhylomeDB; Q9P3T8; -.
DR   PRO; PR:Q9P3T8; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:1990727; C:tubulin folding cofactor complex; NAS:PomBase.
DR   GO; GO:0005096; F:GTPase activator activity; ISO:PomBase.
DR   GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   GO; GO:0007021; P:tubulin complex assembly; IBA:GO_Central.
DR   Gene3D; 1.20.58.1250; -; 1.
DR   Gene3D; 2.160.20.70; -; 1.
DR   InterPro; IPR017901; C-CAP_CF_C-like.
DR   InterPro; IPR016098; CAP/MinC_C.
DR   InterPro; IPR006599; CARP_motif.
DR   InterPro; IPR027684; TBCC.
DR   InterPro; IPR038397; TBCC_N_sf.
DR   InterPro; IPR012945; Tubulin-bd_cofactor_C_dom.
DR   PANTHER; PTHR15139; PTHR15139; 1.
DR   Pfam; PF07986; TBCC; 1.
DR   SMART; SM00673; CARP; 2.
DR   PROSITE; PS51329; C_CAP_COFACTOR_C; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT   CHAIN           1..259
FT                   /note="Tubulin-specific chaperone C"
FT                   /id="PRO_0000337255"
FT   DOMAIN          112..241
FT                   /note="C-CAP/cofactor C-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00659"
SQ   SEQUENCE   259 AA;  30075 MW;  F1CB0C9AE4D0A38C CRC64;
     MSEKFVELRK EFLTKLYKST PSEQTSRSEK ETWLEEKSKY LGEMTRELNE VQDQIAPYDR
     RVCMEQLVDL TRRLQQIRHD ILPRQPFRFQ RALHVKSSQK PVKNITVNAE APEVYFENDT
     LYLANLKNQN IGDNVIPYPN NKAVKVSAKS LRSCNISISN CSSVNLHNAT KCNFTFPTIQ
     GSIHLSDIND STICVSCHQF RLHHSTNLRV HLRCKTSPVI EESKEISFSY KDEHPILDFT
     WARSDPSPHF RITSDLFDA