TBCC_YEAST
ID TBCC_YEAST Reviewed; 268 AA.
AC P46670; D6W3D0; Q08973;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Tubulin-specific chaperone C;
DE AltName: Full=Chromosome instability protein 2;
DE AltName: Full=Tubulin-folding cofactor C;
GN Name=CIN2; OrderedLocusNames=YPL241C; ORFNames=P1043;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Stearns T., Kwon D., Shin K.;
RL Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Tubulin-folding protein; involved in the early step of the
CC tubulin folding pathway.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- MISCELLANEOUS: Present with 1630 molecules/cell.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U34961; AAA78272.1; -; Genomic_DNA.
DR EMBL; Z73597; CAA97962.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11196.1; -; Genomic_DNA.
DR PIR; S65270; S65270.
DR RefSeq; NP_015083.1; NM_001184055.1.
DR PDB; 5CYA; X-ray; 2.00 A; A/B=1-268.
DR PDBsum; 5CYA; -.
DR AlphaFoldDB; P46670; -.
DR SMR; P46670; -.
DR BioGRID; 35922; 260.
DR DIP; DIP-3960N; -.
DR IntAct; P46670; 1.
DR STRING; 4932.YPL241C; -.
DR MaxQB; P46670; -.
DR PaxDb; P46670; -.
DR PRIDE; P46670; -.
DR EnsemblFungi; YPL241C_mRNA; YPL241C; YPL241C.
DR GeneID; 855835; -.
DR KEGG; sce:YPL241C; -.
DR SGD; S000006162; CIN2.
DR VEuPathDB; FungiDB:YPL241C; -.
DR eggNOG; ENOG502S4TX; Eukaryota.
DR HOGENOM; CLU_095426_0_0_1; -.
DR InParanoid; P46670; -.
DR OMA; NERITQS; -.
DR BioCyc; YEAST:G3O-34127-MON; -.
DR PRO; PR:P46670; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; P46670; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IDA:SGD.
DR GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IGI:SGD.
DR GO; GO:0007021; P:tubulin complex assembly; IMP:SGD.
DR DisProt; DP00778; -.
DR Gene3D; 2.160.20.70; -; 1.
DR InterPro; IPR017901; C-CAP_CF_C-like.
DR InterPro; IPR016098; CAP/MinC_C.
DR InterPro; IPR027684; TBCC.
DR PANTHER; PTHR15139; PTHR15139; 1.
DR PROSITE; PS51329; C_CAP_COFACTOR_C; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chaperone; Cytoplasm; Cytoskeleton; Microtubule;
KW Reference proteome.
FT CHAIN 1..268
FT /note="Tubulin-specific chaperone C"
FT /id="PRO_0000089762"
FT DOMAIN 98..255
FT /note="C-CAP/cofactor C-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00659"
FT CONFLICT 66
FT /note="E -> Y (in Ref. 1; AAA78272)"
FT /evidence="ECO:0000305"
FT STRAND 103..105
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 107..110
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 116..122
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 124..127
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 136..148
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 150..154
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 157..170
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 172..177
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 184..192
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 194..199
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 208..214
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 216..221
FT /evidence="ECO:0007829|PDB:5CYA"
FT HELIX 222..227
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 228..232
FT /evidence="ECO:0007829|PDB:5CYA"
FT STRAND 248..251
FT /evidence="ECO:0007829|PDB:5CYA"
FT HELIX 256..258
FT /evidence="ECO:0007829|PDB:5CYA"
FT HELIX 260..267
FT /evidence="ECO:0007829|PDB:5CYA"
SQ SEQUENCE 268 AA; 30709 MW; CE9F2DB6B76997A8 CRC64;
MDFTAKIKEL ERELSETSDY KTLQKKTISL RSELNTLSHS LTSYEKEHFS NDIENVLKSI
NAKLSESKGK KRLFSFKQKN SSSAVHKNVE RTELANAPAY TTTLKKHYVL EKGDSAFENL
EFCTVTSTTD YSGNSALSGS LCFRNITKCV INLQRIFFQT GSIFITDCTD SIIFLRSPSD
KDFQIRLRDL KNCKILIEKL SPSIDCKQVV IIENCHKCIF NASTRDHLII QDFSNPFQSE
ETEDNSAFAF EDFDICNKDT MQLFRAYL
