TBCD7_BOVIN
ID TBCD7_BOVIN Reviewed; 293 AA.
AC Q5E9C4; F1MHE9; Q17QV4;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=TBC1 domain family member 7;
GN Name=TBC1D7;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the TSC-TBC complex, that contains TBC1D7 in
CC addition to the TSC1-TSC2 complex and consists of the functional
CC complex possessing GTPase-activating protein (GAP) activity toward RHEB
CC in response to alterations in specific cellular growth conditions. The
CC small GTPase RHEB is a direct activator of the protein kinase activity
CC of mTORC1 and the TSC-TBC complex acts as a negative regulator of
CC mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in
CC the proper sensing of growth factors and glucose, but not amino acids,
CC by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating
CC protein and additional studies are required to answer this question (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the TSC-TBC complex (also named Rhebulator
CC complex), composed of the TSC1-TSC2 heterodimer and TBC1D7. Interacts
CC with TSC1 (via C-terminal half of the coiled-coil domain) (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}. Note=Localizes
CC in the cytoplasmic vesicles of the endomembrane in association with
CC TSC1-TSC2 complex. {ECO:0000250}.
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DR EMBL; BT020996; AAX09013.1; -; mRNA.
DR EMBL; DAAA02055699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DAAA02055700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC118160; AAI18161.1; -; mRNA.
DR RefSeq; NP_001015643.1; NM_001015643.2.
DR AlphaFoldDB; Q5E9C4; -.
DR SMR; Q5E9C4; -.
DR STRING; 9913.ENSBTAP00000022819; -.
DR PaxDb; Q5E9C4; -.
DR PRIDE; Q5E9C4; -.
DR Ensembl; ENSBTAT00000022819; ENSBTAP00000022819; ENSBTAG00000017160.
DR GeneID; 532704; -.
DR KEGG; bta:532704; -.
DR CTD; 51256; -.
DR VEuPathDB; HostDB:ENSBTAG00000017160; -.
DR VGNC; VGNC:50071; TBC1D7.
DR eggNOG; ENOG502QPZD; Eukaryota.
DR GeneTree; ENSGT00390000009122; -.
DR HOGENOM; CLU_082520_0_0_1; -.
DR InParanoid; Q5E9C4; -.
DR OMA; VMHTMWL; -.
DR OrthoDB; 1440539at2759; -.
DR TreeFam; TF323655; -.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000017160; Expressed in oocyte and 105 other tissues.
DR ExpressionAtlas; Q5E9C4; baseline and differential.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR GO; GO:0033596; C:TSC1-TSC2 complex; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0090630; P:activation of GTPase activity; ISS:UniProtKB.
DR GO; GO:1902018; P:negative regulation of cilium assembly; IEA:Ensembl.
DR GO; GO:0032007; P:negative regulation of TOR signaling; ISS:UniProtKB.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; ISS:UniProtKB.
DR GO; GO:0070848; P:response to growth factor; ISS:UniProtKB.
DR Gene3D; 1.10.8.680; -; 1.
DR InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR InterPro; IPR039842; TBC1D7.
DR InterPro; IPR043039; TBC1D7_dom2.
DR PANTHER; PTHR13530; PTHR13530; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SUPFAM; SSF47923; SSF47923; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; GTPase activation; Reference proteome.
FT CHAIN 1..293
FT /note="TBC1 domain family member 7"
FT /id="PRO_0000208030"
FT DOMAIN 50..231
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT CONFLICT 108
FT /note="Y -> C (in Ref. 1; AAX09013 and 3; AAI18161)"
FT /evidence="ECO:0000305"
FT CONFLICT 155
FT /note="M -> T (in Ref. 1; AAX09013 and 3; AAI18161)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 293 AA; 33904 MW; 9EC5D2023F8CBC68 CRC64;
MTEDSQRNFR SVYYEKVGFR GVEEKKSLEI LLKDDRLDIE KLCTFSQRFP LPSMYRALVW
KVLLGILPPH HESHVQVMTY RKEQYSDVLH ALKVIRFVSD ATPQSEVYLY MHRLESGKLP
RSPSFPLEPE DEVFLAIAKA MEEMVEDSVD CYWIMRCFVN QLNSKYRDTL PQLPKAFEQY
LNLEDSRLLS HLKACCAVST LPYELWFKKC FAGCLPESSL QRIWDKVVSG SCKILVFVAV
EILLTFKIKV MALNSAEKIT KFLENIPQDS SDAIVSKAID LWHKHCGTPV HSA
