ID   TBCD7_DANRE             Reviewed;         294 AA.
AC   F1QRX7; Q6PBQ9;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=TBC1 domain family member 7;
GN   Name=tbc1d7;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the TSC-TBC complex, that contains tbc1d7 in
CC       addition to the TSC1-TSC2 complex and consists of the functional
CC       complex possessing GTPase-activating protein (GAP) activity toward rheb
CC       in response to alterations in specific cellular growth conditions. The
CC       small GTPase rheb is a direct activator of the protein kinase activity
CC       of mTORC1 and the TSC-TBC complex acts as a negative regulator of
CC       mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the TSC-TBC complex (also named Rhebulator
CC       complex). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}.
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DR   EMBL; CABZ01076171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01076172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01076173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC059618; AAH59618.1; -; mRNA.
DR   RefSeq; NP_957071.1; NM_200777.1.
DR   AlphaFoldDB; F1QRX7; -.
DR   SMR; F1QRX7; -.
DR   STRING; 7955.ENSDARP00000040264; -.
DR   PaxDb; F1QRX7; -.
DR   PRIDE; F1QRX7; -.
DR   Ensembl; ENSDART00000040265; ENSDARP00000040264; ENSDARG00000029581.
DR   GeneID; 393750; -.
DR   KEGG; dre:393750; -.
DR   CTD; 51256; -.
DR   ZFIN; ZDB-GENE-040426-1747; tbc1d7.
DR   eggNOG; ENOG502QPZD; Eukaryota.
DR   GeneTree; ENSGT00390000009122; -.
DR   InParanoid; F1QRX7; -.
DR   OMA; VMHTMWL; -.
DR   OrthoDB; 1440539at2759; -.
DR   PhylomeDB; F1QRX7; -.
DR   TreeFam; TF323655; -.
DR   PRO; PR:F1QRX7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 20.
DR   Bgee; ENSDARG00000029581; Expressed in muscle tissue and 20 other tissues.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; ISS:UniProtKB.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0070848; P:response to growth factor; ISS:UniProtKB.
DR   Gene3D; 1.10.8.680; -; 1.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR039842; TBC1D7.
DR   InterPro; IPR043039; TBC1D7_dom2.
DR   PANTHER; PTHR13530; PTHR13530; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; GTPase activation; Reference proteome.
FT   CHAIN           1..294
FT                   /note="TBC1 domain family member 7"
FT                   /id="PRO_0000419487"
FT   DOMAIN          50..232
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   CONFLICT        103
FT                   /note="P -> Q (in Ref. 2; AAH59618)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        254
FT                   /note="M -> I (in Ref. 2; AAH59618)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        260
FT                   /note="I -> V (in Ref. 2; AAH59618)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   294 AA;  33989 MW;  97E784D56165A2EA CRC64;
     MADDPQRNFR SAYYEKVGFR GVEEKKSLEI LLKDNPLDVE KLSTFSQRFP LPSMYRIHVW
     KVLLGILPPH SDSHALVRQY RVDQFEDVSC ALTVMRFIHA STPQTEIYLR MFQLENHTLP
     RRTELRPPDA EDENFLAIAR AMEEIVDDPV DCFWLVRCFI NQFKHKFGDS IPHLPKSLEH
     FLSQEDVCLL SHLKASGALA LLPYSLWFRR CFAGCLPESS LQRVWDKVIS GSCKILVFVA
     VEILLSHKIV IMGMNQPDAI YHFLSNMPQE NTDAIVTKAI DLWHKYCGTP MHSV