ID   TBCD7_XENTR             Reviewed;         293 AA.
AC   F6UMY3; F6RRZ2; Q0VA74; Q28GE3;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=TBC1 domain family member 7;
GN   Name=tbc1d7; ORFNames=TEgg086p06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the TSC-TBC complex, that contains tbc1d7 in
CC       addition to the TSC1-TSC2 complex and consists of the functional
CC       complex possessing GTPase-activating protein (GAP) activity toward rheb
CC       in response to alterations in specific cellular growth conditions. The
CC       small GTPase rheb is a direct activator of the protein kinase activity
CC       of mTORC1 and the TSC-TBC complex acts as a negative regulator of
CC       mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the TSC-TBC complex (also named Rhebulator
CC       complex). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=F6UMY3-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=F6UMY3-2; Sequence=VSP_044197;
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DR   EMBL; CR761423; CAJ82285.1; -; mRNA.
DR   EMBL; AAMC01015138; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC121213; AAI21214.1; -; mRNA.
DR   RefSeq; NP_001016332.2; NM_001016332.3.
DR   RefSeq; XP_012820148.1; XM_012964694.2.
DR   AlphaFoldDB; F6UMY3; -.
DR   SMR; F6UMY3; -.
DR   STRING; 8364.ENSXETP00000002327; -.
DR   PaxDb; F6UMY3; -.
DR   DNASU; 549086; -.
DR   GeneID; 549086; -.
DR   KEGG; xtr:549086; -.
DR   CTD; 51256; -.
DR   Xenbase; XB-GENE-489046; tbc1d7.
DR   eggNOG; ENOG502QPZD; Eukaryota.
DR   HOGENOM; CLU_082520_0_0_1; -.
DR   InParanoid; F6UMY3; -.
DR   OMA; WIRCGGA; -.
DR   OrthoDB; 1440539at2759; -.
DR   TreeFam; TF323655; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; ISS:UniProtKB.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; ISS:UniProtKB.
DR   GO; GO:0070848; P:response to growth factor; ISS:UniProtKB.
DR   Gene3D; 1.10.8.680; -; 1.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   InterPro; IPR039842; TBC1D7.
DR   InterPro; IPR043039; TBC1D7_dom2.
DR   PANTHER; PTHR13530; PTHR13530; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasmic vesicle; GTPase activation;
KW   Reference proteome.
FT   CHAIN           1..293
FT                   /note="TBC1 domain family member 7"
FT                   /id="PRO_0000419488"
FT   DOMAIN          50..231
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   VAR_SEQ         1
FT                   /note="M -> MRPSFSILTTDAVQIM (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_044197"
FT   CONFLICT        69
FT                   /note="H -> Q (in Ref. 1; CAJ82285 and 3; AAI21214)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        251
FT                   /note="T -> M (in Ref. 3; AAI21214)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   293 AA;  34283 MW;  B99EAD9861138038 CRC64;
     MSEDSQRNFR SVYYEKVGFR GVEEKKSLEI LLKDDRLDIE KLCTFSQRFP LPSMYRILVW
     KVLLGILPHH QESHPMVMEY RREQYQDVYH ALQVIHFISE ATPKIEVFLY MYHLETGKLS
     QSQPYPMEPE DDIFLAIAST MEEMVDDDVD CYWLIRNFVN HFDSKFKDSK LQLHKAFEHY
     LNLEDSRLVA HLKASSALEK LPYDLWFKKC FAGCLSASSL QRVWDKLVSG SCKILVFVAV
     EILLTYKLKV TALNNAESIN KFLEKIPEDN TDPIVSKAID LWHKHCGIPA HSI