ID   TBCEL_RAT               Reviewed;         424 AA.
AC   Q5PQJ7;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Tubulin-specific chaperone cofactor E-like protein;
DE   AltName: Full=Leucine-rich repeat-containing protein 35;
GN   Name=Tbcel; Synonyms=Lrrc35;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Acts as a regulator of tubulin stability. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
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DR   EMBL; BC087163; AAH87163.1; -; mRNA.
DR   RefSeq; NP_001014111.1; NM_001014089.1.
DR   AlphaFoldDB; Q5PQJ7; -.
DR   SMR; Q5PQJ7; -.
DR   STRING; 10116.ENSRNOP00000056698; -.
DR   iPTMnet; Q5PQJ7; -.
DR   PhosphoSitePlus; Q5PQJ7; -.
DR   jPOST; Q5PQJ7; -.
DR   PaxDb; Q5PQJ7; -.
DR   GeneID; 315591; -.
DR   KEGG; rno:315591; -.
DR   UCSC; RGD:1308880; rat.
DR   CTD; 219899; -.
DR   RGD; 1308880; Tbcel.
DR   VEuPathDB; HostDB:ENSRNOG00000032364; -.
DR   eggNOG; KOG2982; Eukaryota.
DR   HOGENOM; CLU_017716_1_1_1; -.
DR   InParanoid; Q5PQJ7; -.
DR   OMA; TYLDWAC; -.
DR   OrthoDB; 1495296at2759; -.
DR   PhylomeDB; Q5PQJ7; -.
DR   PRO; PR:Q5PQJ7; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000032364; Expressed in testis and 18 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0043014; F:alpha-tubulin binding; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007023; P:post-chaperonin tubulin folding pathway; IBA:GO_Central.
DR   GO; GO:0007021; P:tubulin complex assembly; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR044994; TBCE.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR15140; PTHR15140; 1.
DR   Pfam; PF14560; Ubiquitin_2; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Leucine-rich repeat; Phosphoprotein;
KW   Reference proteome; Repeat.
FT   CHAIN           1..424
FT                   /note="Tubulin-specific chaperone cofactor E-like protein"
FT                   /id="PRO_0000239670"
FT   REPEAT          73..98
FT                   /note="LRR 1"
FT   REPEAT          99..123
FT                   /note="LRR 2"
FT   REPEAT          124..147
FT                   /note="LRR 3"
FT   REPEAT          150..172
FT                   /note="LRR 4"
FT   REPEAT          173..197
FT                   /note="LRR 5"
FT   REPEAT          199..224
FT                   /note="LRR 6"
FT   REPEAT          226..250
FT                   /note="LRR 7"
FT   DOMAIN          262..303
FT                   /note="LRRCT"
FT   DOMAIN          334..424
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   COILED          350..375
FT                   /evidence="ECO:0000255"
FT   MOD_RES         18
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         41
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5QJ74"
SQ   SEQUENCE   424 AA;  48046 MW;  33F3840D27566B7F CRC64;
     MDQPSGRSFM QVLCEKYSPE NFPYRRGPGM GVHVPATPQG SPMKDRLNLP SVLVLNSCGI
     TCAGDEREIA AFCAHVSELD LSDNKLQDWH EVSKIVSNVP QLEFLNLSSN PLSLSVLERT
     CAGSFSGVRK LVLNNSKASW ETVHTILQEL PDLEELFLCL NDYETVSCPS VCCHSLKLLH
     ITDNNLQEWT EIRKLGVMFP SLDTLVLANN HVNAIEEPAD SLARLFPNLR SISLHKSGLQ
     SWEDIDKLNS FPKLEEVRLL GIPLLQPYTT EERRKLVVAR LPSVSKLNGS VVTDGEREDS
     ERFFIRYYVD VPQEEVPFRY HELITKYGKL EPLAEVDLRP QSSAKVEVHF NDQVEEVSIR
     LDQTVAELKR QLKTLVQLPT SSMLLYYFDH EAPFGPEEMK YSSRALHSFG IRDGDKIFVE
     SKTK