ID   TBD2B_XENTR             Reviewed;         943 AA.
AC   Q28CB1;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=TBC1 domain family member 2B;
GN   Name=tbc1d2b; ORFNames=TGas126k13.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: GTPase-activating protein that plays a role in the early
CC       steps of endocytosis. {ECO:0000250|UniProtKB:Q9UPU7}.
CC   -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q9UPU7}.
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DR   EMBL; CR942358; CAJ81581.1; -; mRNA.
DR   EMBL; BC121891; AAI21892.1; -; mRNA.
DR   RefSeq; NP_001039198.1; NM_001045733.1.
DR   AlphaFoldDB; Q28CB1; -.
DR   SMR; Q28CB1; -.
DR   STRING; 8364.ENSXETP00000021491; -.
DR   PaxDb; Q28CB1; -.
DR   GeneID; 734055; -.
DR   KEGG; xtr:734055; -.
DR   CTD; 23102; -.
DR   Xenbase; XB-GENE-5932742; tbc1d2b.
DR   eggNOG; KOG2058; Eukaryota.
DR   InParanoid; Q28CB1; -.
DR   OrthoDB; 1162786at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; GTPase activation; Reference proteome.
FT   CHAIN           1..943
FT                   /note="TBC1 domain family member 2B"
FT                   /id="PRO_0000315715"
FT   DOMAIN          32..129
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          642..836
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          315..514
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   943 AA;  109377 MW;  AFA1282D879C1545 CRC64;
     MPGVEDPCDS QGTPPEEPST SVAPGEAAKE QSPRLCGYLA KLSGKGPLRS FKNRWFVLDP
     RKCQFYYFKH HQDAQPLGQI DIGDASFSYD LEAEEGQFEI HSAGRVSILR APSRHAMTYW
     LQELQQKRWE YCNSFGALKR ESVINPASTK VPIGLVARES PDYMGIPNIN DAERARNQFA
     VETCPSVLGD QTSAEQASNN PAAVQVLLRQ WSNDIRSSMQ HLRPGKSSDC RKSTFYTNEE
     WELLNPTPKE LEESLLHVEK RKPPTEGIKG STGMSFPFDF GRIPQRARRP LREIMGVNKN
     RTECLADSLP VSDSRMESDV LLKLQSQEEE LERLKKDLLS QKELVRLLQQ SLRSSQYDKY
     FASPFCDGLS KEHLHLLQQK DTQIQELNHL LERQTLEKDH LHQEVEELKC SVKELKDQLN
     MMMETIQAKD EVIMRLSRQL SKYEQHTPSS TVAAEIPVAP QLEELNRLQD SLQGYKAQNT
     FLNKEILELS ALRRNAERRE REMEARYSNL EAKMCQIESK YLVLLQEMKT PVCSDDQGTA
     REFVNQLLED ALKVENAEQP EHTFVKPHTV SKYDIHGFLI VPEDDEEEEK LVAKVRALDL
     KTLSLTENQE ISNVVKWDNY FASTVNREMA CSPELKALVR NGIPHEHRSR MWKWFTNLHI
     KKLKDEAAPG YFQSLLQNAL EKQNPASKQI ELDLMRTLPN NKHYTSPTSE GIQKLRNVLL
     AYSWRNPDIG YCQGINRLAA IALLYLDQED AFWCLVTIVE AFMPRDYYTK TLLGSQVDQR
     VFKDLMNEKL PRLCAHFEQY KVDYTLITFN WFLVVFVDSV VSDILFRIWD SLLYEGSKVI
     FRFALGLFKY KEEEILKLQD SMSIFKYLRY FSRTILDARK LCNIAFVDMN PFPLRQIRNR
     RTYHLEKVRL ELSELEAIRA DFIRERETNP ERRDLISDDE EDS