ID   TBD_CANLF               Reviewed;         453 AA.
AC   Q8HZV4;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Tubulin delta chain;
DE   AltName: Full=Delta-tubulin;
GN   Name=TUBD1; Synonyms=TUBD;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12047234; DOI=10.1046/j.1365-2052.2002.0831d.x;
RA   Sidjanin D.J., Zangerl B., Johnson J.L., Xue F., Mellersh C.,
RA   Ostrander E.A., Acland G.M., Aguirre G.D.;
RT   "Cloning of the canine delta tubulin cDNA (TUBD) and mapping to CFA9.";
RL   Anim. Genet. 33:161-162(2002).
CC   -!- FUNCTION: Acts as a positive regulator of hedgehog signaling and
CC       regulates ciliary function. {ECO:0000250|UniProtKB:Q9R1K7}.
CC   -!- SUBUNIT: Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1.
CC       {ECO:0000250|UniProtKB:Q9R1K7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9R1K7}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9R1K7}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q9R1K7}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9R1K7}. Note=Associated with centrioles. Both
CC       cytoplasmic and nuclear. In the elongating spermatid it is associated
CC       with the manchette, a specialized microtubule system present during
CC       reshaping of the sperm head. {ECO:0000250|UniProtKB:Q9R1K7}.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF416724; AAN32643.1; -; mRNA.
DR   RefSeq; NP_001003024.1; NM_001003024.1.
DR   RefSeq; XP_005624378.1; XM_005624321.2.
DR   RefSeq; XP_013971935.1; XM_014116460.1.
DR   AlphaFoldDB; Q8HZV4; -.
DR   SMR; Q8HZV4; -.
DR   STRING; 9615.ENSCAFP00000052240; -.
DR   PaxDb; Q8HZV4; -.
DR   PRIDE; Q8HZV4; -.
DR   Ensembl; ENSCAFT00030008426; ENSCAFP00030007401; ENSCAFG00030004436.
DR   Ensembl; ENSCAFT00040003000; ENSCAFP00040002593; ENSCAFG00040001537.
DR   Ensembl; ENSCAFT00845045938; ENSCAFP00845036064; ENSCAFG00845025976.
DR   GeneID; 403546; -.
DR   KEGG; cfa:403546; -.
DR   CTD; 51174; -.
DR   VEuPathDB; HostDB:ENSCAFG00845025976; -.
DR   eggNOG; KOG1374; Eukaryota.
DR   GeneTree; ENSGT00940000157069; -.
DR   HOGENOM; CLU_015718_1_0_1; -.
DR   InParanoid; Q8HZV4; -.
DR   OMA; ACHPEYK; -.
DR   OrthoDB; 1166669at2759; -.
DR   TreeFam; TF329833; -.
DR   Proteomes; UP000002254; Chromosome 9.
DR   Bgee; ENSCAFG00000017668; Expressed in saliva-secreting gland and 46 other tissues.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR002967; Delta_tubulin.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR017975; Tubulin_CS.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   PANTHER; PTHR11588:SF4; PTHR11588:SF4; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   PRINTS; PR01224; DELTATUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SMART; SM00864; Tubulin; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
DR   SUPFAM; SSF55307; SSF55307; 1.
DR   PROSITE; PS00227; TUBULIN; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Developmental protein; GTP-binding; Microtubule; Nucleotide-binding;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..453
FT                   /note="Tubulin delta chain"
FT                   /id="PRO_0000048483"
FT   BINDING         143..149
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   453 AA;  50849 MW;  F7A20397DFD9DF2A CRC64;
     MSVVTVQLGQ CGNQIGFEVF DALYSDSHCP QGLCSERENE AYQASSKERF FSEEENGVSI
     ARAVLVDMEP KVINQTLSKA AQSGQWKYAQ HSCFCQKEGS GNNWAYGYSV HGPRHEESIM
     NLIQKEVEKC DSLSGFFIIM SMAGGTGSGL GAFVTQNLQD QYSNSLKMNQ IIWPYGTGEV
     IVQNYNSVLT LSHLYRSSDA LLVHENDAIH KICAKLMNIK QISFSDINQV LAHQLGSVFQ
     PTYSVEGSCH YRRNPLGDLM ENLVPHPEFK MLGIRNIPQM SENSLTYSTF TWAGLLKHLR
     QMLISNSKME EGINWQVRPP LPGLPTLGKV SLNRELHFNT SIANLVILRG KDVHSADLGG
     FKDPALYTSW LEPIDAFNVW KTQRAFSKYE KSAALVSNSQ FLLKPLDTIV GKAWNMFASK
     AYIHQYTKFG IEEEDFLDSF TLLEQVVASY CNL