ID   TBD_MACFA               Reviewed;         453 AA.
AC   Q4R7T7;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Tubulin delta chain;
DE   AltName: Full=Delta-tubulin;
GN   Name=TUBD1; ORFNames=QtsA-14412;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a positive regulator of hedgehog signaling and
CC       regulates ciliary function. {ECO:0000250|UniProtKB:Q9R1K7}.
CC   -!- SUBUNIT: Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1.
CC       {ECO:0000250|UniProtKB:Q9R1K7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9R1K7}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9R1K7}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q9R1K7}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9R1K7}. Note=Associated with centrioles. Both
CC       cytoplasmic and nuclear. In the elongating spermatid it is associated
CC       with the manchette, a specialized microtubule system present during
CC       reshaping of the sperm head. {ECO:0000250|UniProtKB:Q9R1K7}.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR   EMBL; AB168725; BAE00835.1; -; mRNA.
DR   RefSeq; NP_001272233.1; NM_001285304.1.
DR   AlphaFoldDB; Q4R7T7; -.
DR   SMR; Q4R7T7; -.
DR   STRING; 9541.XP_005583937.1; -.
DR   PRIDE; Q4R7T7; -.
DR   GeneID; 101865715; -.
DR   CTD; 51174; -.
DR   eggNOG; KOG1374; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.10.287.600; -; 1.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR002967; Delta_tubulin.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR023123; Tubulin_C.
DR   InterPro; IPR017975; Tubulin_CS.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   PANTHER; PTHR11588:SF4; PTHR11588:SF4; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   PRINTS; PR01224; DELTATUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SMART; SM00864; Tubulin; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
DR   SUPFAM; SSF55307; SSF55307; 1.
DR   PROSITE; PS00227; TUBULIN; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   Developmental protein; GTP-binding; Microtubule; Nucleotide-binding;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..453
FT                   /note="Tubulin delta chain"
FT                   /id="PRO_0000233351"
FT   BINDING         143..149
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   453 AA;  51035 MW;  A8573A9B05A05628 CRC64;
     MSIVTVQLGQ CGNQIGFEVF DALLSDSHSS QGLCCKRENE AYQASCKERF FSEEENGVPI
     ARAVLVDMEP KVINQTLSKA AQSGRWKYGQ HACFCQKQGS GNNWAYGYSV HGPRHEESIM
     DLIRKEVEKC DSFSGFFIIM SMAGGTGSGI GAFVTQNLQD QYSNSLKMNQ IIWPYGTGEV
     IVQNYNSILT LSHLYRSSDA LLVHENDAVH KICAKLMNIK QISFSDINQV LAHQLGSVFQ
     PTYSAESSFH YRRNPLGDLM EHLVPHPEFK MLSIRNVPHM SENSLAYSTF TWAGLLKHLR
     QMLISNAKME EGIDWHARPP LSGLPSLGKM SLNKDLHFNT SIANLVILRG KDVQSADVEG
     FKDPALYTSW LEPVNAFNVW KTQRAFSKYE KSAVLVSNSQ FLVKPLDMIV RKAWNMFASK
     AYIHQYTKFG IEEEDFLDSF TSLEQVVASY CNL