TBD_MOUSE
ID TBD_MOUSE Reviewed; 455 AA.
AC Q9R1K7;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Tubulin delta chain;
DE AltName: Full=Delta-tubulin;
GN Name=Tubd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=10753753; DOI=10.1016/s0960-9822(00)00418-8;
RA Smrzka O.W., Delgehyr N., Bornens M.;
RT "Tissue-specific expression and subcellular localisation of mammalian
RT delta-tubulin.";
RL Curr. Biol. 10:413-416(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=29290584; DOI=10.1016/j.devcel.2017.12.003;
RA Pusapati G.V., Kong J.H., Patel B.B., Krishnan A., Sagner A., Kinnebrew M.,
RA Briscoe J., Aravind L., Rohatgi R.;
RT "CRISPR screens uncover genes that regulate target cell sensitivity to the
RT morphogen sonic hedgehog.";
RL Dev. Cell 44:113-129(2018).
RN [4]
RP SUBUNIT, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=29459677; DOI=10.1038/s41588-018-0054-7;
RA Breslow D.K., Hoogendoorn S., Kopp A.R., Morgens D.W., Vu B.K.,
RA Kennedy M.C., Han K., Li A., Hess G.T., Bassik M.C., Chen J.K.,
RA Nachury M.V.;
RT "A CRISPR-based screen for Hedgehog signaling provides insights into
RT ciliary function and ciliopathies.";
RL Nat. Genet. 50:460-471(2018).
CC -!- FUNCTION: Acts as a positive regulator of hedgehog signaling and
CC regulates ciliary function (PubMed:29290584).
CC {ECO:0000269|PubMed:29290584}.
CC -!- SUBUNIT: Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1.
CC {ECO:0000269|PubMed:29459677}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000269|PubMed:29290584}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome, centriole {ECO:0000269|PubMed:10753753}.
CC Cytoplasm {ECO:0000269|PubMed:10753753}. Nucleus
CC {ECO:0000269|PubMed:10753753}. Note=Associated with centrioles
CC (PubMed:10753753). Both cytoplasmic and nuclear (PubMed:10753753). In
CC the elongating spermatid it is associated with the manchette, a
CC specialized microtubule system present during reshaping of the sperm
CC head (PubMed:10753753). {ECO:0000269|PubMed:10753753}.
CC -!- TISSUE SPECIFICITY: Highly expressed in testis.
CC -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR EMBL; AF081568; AAD52009.1; -; mRNA.
DR EMBL; BC026465; AAH26465.1; -; mRNA.
DR CCDS; CCDS25202.1; -.
DR RefSeq; NP_001185976.1; NM_001199047.1.
DR RefSeq; NP_062730.1; NM_019756.3.
DR AlphaFoldDB; Q9R1K7; -.
DR SMR; Q9R1K7; -.
DR BioGRID; 207971; 1.
DR STRING; 10090.ENSMUSP00000064383; -.
DR iPTMnet; Q9R1K7; -.
DR PhosphoSitePlus; Q9R1K7; -.
DR PRIDE; Q9R1K7; -.
DR ProteomicsDB; 263082; -.
DR Antibodypedia; 3899; 136 antibodies from 25 providers.
DR DNASU; 56427; -.
DR Ensembl; ENSMUST00000069503; ENSMUSP00000064383; ENSMUSG00000020513.
DR Ensembl; ENSMUST00000167178; ENSMUSP00000130909; ENSMUSG00000020513.
DR GeneID; 56427; -.
DR KEGG; mmu:56427; -.
DR UCSC; uc007kss.1; mouse.
DR CTD; 51174; -.
DR MGI; MGI:1891826; Tubd1.
DR VEuPathDB; HostDB:ENSMUSG00000020513; -.
DR eggNOG; KOG1374; Eukaryota.
DR GeneTree; ENSGT00940000157069; -.
DR HOGENOM; CLU_015718_1_0_1; -.
DR InParanoid; Q9R1K7; -.
DR OMA; ACHPEYK; -.
DR TreeFam; TF329833; -.
DR BioGRID-ORCS; 56427; 13 hits in 72 CRISPR screens.
DR ChiTaRS; Tubd1; mouse.
DR PRO; PR:Q9R1K7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9R1K7; protein.
DR Bgee; ENSMUSG00000020513; Expressed in spermatocyte and 150 other tissues.
DR ExpressionAtlas; Q9R1K7; baseline and differential.
DR Genevisible; Q9R1K7; MM.
DR GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IMP:UniProtKB.
DR Gene3D; 1.10.287.600; -; 1.
DR Gene3D; 3.40.50.1440; -; 1.
DR InterPro; IPR002967; Delta_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; PTHR11588; 1.
DR PANTHER; PTHR11588:SF4; PTHR11588:SF4; 1.
DR Pfam; PF00091; Tubulin; 1.
DR PRINTS; PR01224; DELTATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SUPFAM; SSF52490; SSF52490; 1.
DR SUPFAM; SSF55307; SSF55307; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW Developmental protein; GTP-binding; Microtubule; Nucleotide-binding;
KW Nucleus; Reference proteome.
FT CHAIN 1..455
FT /note="Tubulin delta chain"
FT /id="PRO_0000048485"
FT BINDING 143..149
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
SQ SEQUENCE 455 AA; 51023 MW; 97755668BC193092 CRC64;
MSIVTVQLGQ CGNQIGFEVF DALFRDSHCS QGLCSKRDNE AYQASCRERF FREEENGVPV
ARAVLVDMEP KVINQTLSKA AQSGRWNYGQ HTSFCQKQGS GNNWAYGYSV HGPKHEESIM
NLIQTEVEKC DSLSGFFIIM SMAGGTGSGL GAFVTQKLQD QYSSSLKMNQ IIWPYGTGEV
IVQNYNSILT LSHLYRSSDA LLIHENDAVH KICAKRMNIK QISFRDLNQV LAHQLGSVFQ
PTYSEDSSFH YRRNPLGDLM EHLVPHPEFK MLGVRNIPQM SAASLAYSAF TWAGLLKHLR
QMLISSAKME EGINWQVRPP LTGLPPIGKA SAHKEHHFNT SLANLVVLRG REVHSADVEG
FKDPALYTSW LEPVDAFSVW KTQRAFDKYE KSAALVSNSQ LLVKPLDMIV GKAWNMFSSK
AFIHQYTKFG MEEEDFLDSF ALLEQVVASY GSLGP
