ID   TBD_XENTR               Reviewed;         451 AA.
AC   Q6DIM3;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Tubulin delta chain;
DE   AltName: Full=Delta-tubulin;
GN   Name=tubd1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a positive regulator of hedgehog signaling and
CC       regulates ciliary function. {ECO:0000250|UniProtKB:Q9R1K7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9R1K7}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9R1K7}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q9R1K7}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9R1K7}. Note=Associated with centrioles. Both
CC       cytoplasmic and nuclear. In the elongating spermatid it is associated
CC       with the manchette, a specialized microtubule system present during
CC       reshaping of the sperm head. {ECO:0000250|UniProtKB:Q9R1K7}.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR   EMBL; BC075514; AAH75514.1; -; mRNA.
DR   RefSeq; NP_001006747.1; NM_001006746.1.
DR   AlphaFoldDB; Q6DIM3; -.
DR   SMR; Q6DIM3; -.
DR   PaxDb; Q6DIM3; -.
DR   DNASU; 448419; -.
DR   GeneID; 448419; -.
DR   KEGG; xtr:448419; -.
DR   CTD; 51174; -.
DR   Xenbase; XB-GENE-488049; tubd1.
DR   eggNOG; KOG1374; Eukaryota.
DR   InParanoid; Q6DIM3; -.
DR   OrthoDB; 1166669at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000010735; Expressed in testis and 13 other tissues.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.10.287.600; -; 1.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR002967; Delta_tubulin.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR023123; Tubulin_C.
DR   InterPro; IPR017975; Tubulin_CS.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   PANTHER; PTHR11588:SF4; PTHR11588:SF4; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   PRINTS; PR01224; DELTATUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SMART; SM00864; Tubulin; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
DR   SUPFAM; SSF55307; SSF55307; 1.
DR   PROSITE; PS00227; TUBULIN; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Cytoplasm; Cytoskeleton;
KW   GTP-binding; Microtubule; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN           1..451
FT                   /note="Tubulin delta chain"
FT                   /id="PRO_0000260090"
FT   BINDING         143..149
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   451 AA;  51244 MW;  1376B26DC0FAFCAB CRC64;
     MSVVTVQLGQ CGNQVGYEFF DILCSDLHSK PGHSTKREND YYQTVCKEQF FHEEECGDLV
     TRAVLVDMEP KVVSKTLSMA GRSGKWKYDI SSQFSQKQGC GNNWANGYCV HGPKHQDIVM
     DLVRKQVEKC DRLGGFFTIM SMAGGTGSGM GTFLTRCLRD AYPDSLLLNQ VIWPYGTGEV
     IVQNYNSILT LSHLYRSSDA LLVHENDIIH KVCSQLMNIK QISFRDVNKV IAHQLGSIFQ
     PVYTSEEALH YCRNPLGELM ECLVPHPEYK MLGLRNIPQM SEHSLAYSTF NWNGLLKHLR
     QMLIANAKME EGINWHVRPP SQPTAEKTSL RKELQFNTSV ANLAILRGKD VQTASLEGFR
     DPPLYTPWLS PDDAFTLWKT PRAFNKYEKS ATLVSNSQFL LKPLDNIVGK AWNMFASKAY
     VHQYTKFGID EEEFLETFTT LEQIIASYTN L