ID   TBE_MOUSE               Reviewed;         475 AA.
AC   Q9D6T1;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Tubulin epsilon chain;
DE   AltName: Full=Epsilon-tubulin;
GN   Name=Tube1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   SUBUNIT, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=29459677; DOI=10.1038/s41588-018-0054-7;
RA   Breslow D.K., Hoogendoorn S., Kopp A.R., Morgens D.W., Vu B.K.,
RA   Kennedy M.C., Han K., Li A., Hess G.T., Bassik M.C., Chen J.K.,
RA   Nachury M.V.;
RT   "A CRISPR-based screen for Hedgehog signaling provides insights into
RT   ciliary function and ciliopathies.";
RL   Nat. Genet. 50:460-471(2018).
CC   -!- SUBUNIT: Found in a complex with TEDC1, TEDC2, TUBE1 and TUBD1.
CC       {ECO:0000269|PubMed:29459677}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q9UJT0}. Note=Associated with
CC       pericentriolar material. {ECO:0000250|UniProtKB:Q9UJT0}.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR   EMBL; AK010005; BAB26636.1; -; mRNA.
DR   EMBL; AK148039; BAE28305.1; -; mRNA.
DR   EMBL; BC062179; AAH62179.1; -; mRNA.
DR   CCDS; CCDS23787.1; -.
DR   RefSeq; NP_082282.1; NM_028006.2.
DR   AlphaFoldDB; Q9D6T1; -.
DR   SMR; Q9D6T1; -.
DR   BioGRID; 215035; 36.
DR   IntAct; Q9D6T1; 34.
DR   STRING; 10090.ENSMUSP00000019991; -.
DR   PhosphoSitePlus; Q9D6T1; -.
DR   EPD; Q9D6T1; -.
DR   MaxQB; Q9D6T1; -.
DR   PaxDb; Q9D6T1; -.
DR   PeptideAtlas; Q9D6T1; -.
DR   PRIDE; Q9D6T1; -.
DR   ProteomicsDB; 263137; -.
DR   Antibodypedia; 19362; 196 antibodies from 25 providers.
DR   DNASU; 71924; -.
DR   Ensembl; ENSMUST00000019991; ENSMUSP00000019991; ENSMUSG00000019845.
DR   GeneID; 71924; -.
DR   KEGG; mmu:71924; -.
DR   UCSC; uc007evu.1; mouse.
DR   CTD; 51175; -.
DR   MGI; MGI:1919174; Tube1.
DR   VEuPathDB; HostDB:ENSMUSG00000019845; -.
DR   eggNOG; KOG1375; Eukaryota.
DR   GeneTree; ENSGT00940000155723; -.
DR   HOGENOM; CLU_015718_1_0_1; -.
DR   InParanoid; Q9D6T1; -.
DR   OMA; FPSACDD; -.
DR   OrthoDB; 1166669at2759; -.
DR   PhylomeDB; Q9D6T1; -.
DR   TreeFam; TF330882; -.
DR   BioGRID-ORCS; 71924; 7 hits in 70 CRISPR screens.
DR   PRO; PR:Q9D6T1; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q9D6T1; protein.
DR   Bgee; ENSMUSG00000019845; Expressed in metanephric cortical collecting duct and 187 other tissues.
DR   ExpressionAtlas; Q9D6T1; baseline and differential.
DR   Genevisible; Q9D6T1; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR   Gene3D; 1.10.287.600; -; 1.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR004057; Epsilon_tubulin.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR023123; Tubulin_C.
DR   InterPro; IPR017975; Tubulin_CS.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   PANTHER; PTHR11588:SF317; PTHR11588:SF317; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   Pfam; PF03953; Tubulin_C; 1.
DR   PRINTS; PR01519; EPSLNTUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SMART; SM00864; Tubulin; 1.
DR   SMART; SM00865; Tubulin_C; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
DR   SUPFAM; SSF55307; SSF55307; 1.
DR   PROSITE; PS00227; TUBULIN; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..475
FT                   /note="Tubulin epsilon chain"
FT                   /id="PRO_0000233352"
FT   BINDING         148..154
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   475 AA;  52652 MW;  D5CA050DD7DE0DD1 CRC64;
     MTQSVVVQVG QCGNQIGCCF WDLALREHAA VNQKGIYDDA ISSFFRNVDT RAVGDGGSIS
     KGRISSLKAR AVLIDMEEGV VNEILQGPLR DVFDSKQLIT DISGSGNNWA VGHKVFGCLY
     REQILEKLRK SAEQCDCLQC FFIIHSMGGG TGSGLGTFLL KVLEDEFPEV YRFVTAVYPS
     SEDDVITSPY NSMLAMKELN EHADCVLPID NQSLFDIISK IDLVVNSGKL GSAVKPKSLI
     TSNMGAVKKH HKKPFDAMNN IVANLLLSLT SSARFEGSLN MDLNEISMNL VPFPKLHYLV
     SSLTPLYTLA DVNIPPRRLD QMFSDAFSKD HQLIQADPRH SLYLACALIV RGNVQISDLR
     RNIERLKPAL QFVSWNQEGW KTSLCSVPPV GHSHSLLALA NNTCVKPTFM ELRERFTRLY
     KKKAHLHHYL QVDGMEESTF TEAVSSLSAL IQEYSDLDAT KSLPVPDVPR LSVAL