ID   TBFG_EPTST              Reviewed;         603 AA.
AC   Q90502;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Thread biopolymer filament subunit gamma;
OS   Eptatretus stoutii (Pacific hagfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Myxini;
OC   Myxiniformes; Myxinidae; Eptatretinae; Eptatretus.
OX   NCBI_TaxID=7765;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Slime gland;
RX   PubMed=8580093; DOI=10.1016/0141-8130(95)98156-s;
RA   Koch E.A., Spitzer R.H., Pithawalla R.B., Castillos F.A. III, Parry D.A.;
RT   "Hagfish biopolymer: a type I/type II homologue of epidermal keratin
RT   intermediate filaments.";
RL   Int. J. Biol. Macromol. 17:283-292(1995).
CC   -!- FUNCTION: Released extracellularly into seawater and provides physical
CC       and biological defense against invasive organism by modulation of the
CC       viscoelastic properties of mucus.
CC   -!- SUBUNIT: Coiled-coil heterodimer of an alpha and a gamma subunit.
CC       Assemble into 10 nm filaments. Forms a massive, conical, intermediate
CC       filament biopolymer of approximately 60 cm.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; U20546; AAA93157.1; -; mRNA.
DR   AlphaFoldDB; Q90502; -.
DR   SMR; Q90502; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   Pfam; PF00038; Filament; 1.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Intermediate filament; Secreted.
FT   CHAIN           1..603
FT                   /note="Thread biopolymer filament subunit gamma"
FT                   /id="PRO_0000063864"
FT   DOMAIN          158..476
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..191
FT                   /note="Head"
FT   REGION          193..227
FT                   /note="Coil 1A"
FT   REGION          228..240
FT                   /note="Linker 1"
FT   REGION          241..341
FT                   /note="Coil 1B"
FT   REGION          342..362
FT                   /note="Linker 12"
FT   REGION          363..381
FT                   /note="Coil 2A"
FT   REGION          382..389
FT                   /note="Linker 2"
FT   REGION          390..510
FT                   /note="Coil 2B"
FT   REGION          511..603
FT                   /note="Tail"
FT   REGION          562..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   603 AA;  62854 MW;  9389A783D28BE2DF CRC64;
     MASHSSVSYR SVRTGGTSAM IGSSGYGGSS SSRAMGLGMG AAGLSMGGGS FRVGSAGIGG
     MGISSGIGGM GISSRAGGMS AYGGAASGGA GGFVSGGVPM LGYGGGAGGF IGGVSPGIMA
     SPAFTAGRAI TSAGMSGVVG TLGPAGGMVP SLVSRDEVKN ILGTLNQRLA SYVDKVRQLT
     IENETMEEEL KNLTGGVPMS PDSTVNLENV ETQVTEMLTE VSNLTLERVR LEIDVDHLRA
     TADEIKSKYE FELGVRMQLE TDIANMKRDL EAANDMRVDL DSKFNFLTEE LTFQRKTQME
     ELNTLKQQFG RLGPVQTSVI ELDNVKSVNL TDALNVMREE YQQVVTKNVQ EAETYCKMQI
     DQIQGISTQT TEQISILDKE INTLEKELQP LNVEYQRLLT TYQTLGDRLT DLQNRESIDL
     VQFQNTYTRY EQEIEGNQVD LQRQLVTYQQ LLDVKTALDA EIATYKKLLE GQELMVRTAM
     ADDFAHATVV RSGTLGGASS SSVGYGASST TLGAISGGYS TGGGASYSAG AGGASYSAGA
     GGASYGVGGG YSGGSSAMME GSSSGGHSMY SSSSMKRSSS KSASASAGGY GTSGHDSTII
     LQQ