ID   TBG1_BOVIN              Reviewed;         451 AA.
AC   Q0VCD2;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Tubulin gamma-1 chain;
DE   AltName: Full=Gamma-1-tubulin;
GN   Name=TUBG1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Tubulin is the major constituent of microtubules. The gamma
CC       chain is found at microtubule organizing centers (MTOC) such as the
CC       spindle poles or the centrosome. Pericentriolar matrix component that
CC       regulates alpha/beta chain minus-end nucleation, centrosome duplication
CC       and spindle formation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TUBGCP2, TUBGCP3 and B9D2. Interacts with
CC       CDK5RAP2; the interaction is leading to centrosomal localization of
CC       TUBG1 and CDK5RAP2. Interacts with PIFO. Interacts with SAS6 and NUP62
CC       at the centrosome (By similarity). Interacts with EML3 (phosphorylated
CC       form) and HAUS8 (By similarity). {ECO:0000250|UniProtKB:P23258,
CC       ECO:0000250|UniProtKB:P83887}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:P23258}. Cytoplasm,
CC       cytoskeleton, spindle {ECO:0000250|UniProtKB:P23258}. Note=Localizes to
CC       mitotic spindle microtubules. {ECO:0000250|UniProtKB:P23258}.
CC   -!- PTM: Phosphorylation at Ser-131 by BRSK1 regulates centrosome
CC       duplication, possibly by mediating relocation of gamma-tubulin and its
CC       associated proteins from the cytoplasm to the centrosome.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR   EMBL; BC120225; AAI20226.1; -; mRNA.
DR   RefSeq; NP_001069723.1; NM_001076255.2.
DR   AlphaFoldDB; Q0VCD2; -.
DR   SMR; Q0VCD2; -.
DR   BioGRID; 197666; 1.
DR   STRING; 9913.ENSBTAP00000055684; -.
DR   PaxDb; Q0VCD2; -.
DR   PRIDE; Q0VCD2; -.
DR   Ensembl; ENSBTAT00000064686; ENSBTAP00000055684; ENSBTAG00000048152.
DR   GeneID; 541101; -.
DR   KEGG; bta:541101; -.
DR   CTD; 7283; -.
DR   VEuPathDB; HostDB:ENSBTAG00000048152; -.
DR   VGNC; VGNC:49987; TUBG1.
DR   eggNOG; KOG1374; Eukaryota.
DR   GeneTree; ENSGT00940000156957; -.
DR   HOGENOM; CLU_015718_1_0_1; -.
DR   InParanoid; Q0VCD2; -.
DR   OMA; EHGINKE; -.
DR   OrthoDB; 687389at2759; -.
DR   TreeFam; TF300477; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000048152; Expressed in choroid plexus and 106 other tissues.
DR   GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR   GO; GO:0031252; C:cell leading edge; IEA:Ensembl.
DR   GO; GO:0005814; C:centriole; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0000794; C:condensed nuclear chromosome; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005881; C:cytoplasmic microtubule; IEA:Ensembl.
DR   GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:1990498; C:mitotic spindle microtubule; ISS:UniProtKB.
DR   GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR   GO; GO:0097730; C:non-motile cilium; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000242; C:pericentriolar material; IEA:Ensembl.
DR   GO; GO:0005827; C:polar microtubule; ISS:UniProtKB.
DR   GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR   GO; GO:0005819; C:spindle; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR   GO; GO:0000212; P:meiotic spindle organization; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   CDD; cd02188; gamma_tubulin; 1.
DR   Gene3D; 1.10.287.600; -; 1.
DR   Gene3D; 3.30.1330.20; -; 1.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR002454; Gamma_tubulin.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR   InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR023123; Tubulin_C.
DR   InterPro; IPR017975; Tubulin_CS.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   Pfam; PF03953; Tubulin_C; 1.
DR   PRINTS; PR01164; GAMMATUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SMART; SM00864; Tubulin; 1.
DR   SMART; SM00865; Tubulin_C; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
DR   SUPFAM; SSF55307; SSF55307; 1.
DR   PROSITE; PS00227; TUBULIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..451
FT                   /note="Tubulin gamma-1 chain"
FT                   /id="PRO_0000288846"
FT   BINDING         142..148
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         131
FT                   /note="Phosphoserine; by BRSK1"
FT                   /evidence="ECO:0000250|UniProtKB:P83887"
SQ   SEQUENCE   451 AA;  51148 MW;  AC40C01635CA7854 CRC64;
     MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV FFYQADDEHY
     IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA GNNWASGFSQ GEKIHEDIFD
     IIDREADGSD SLEGFVLCHS IAGGTGSGLG SYLLERLNDR YPKKLVQTYS VFPNQDEMSD
     VVVQPYNSLL TLKRLTQNAD CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST
     TTLRYPGYMN NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP
     KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP WGPASIQVAL
     SRKSPYLPSA HRVSGLMMAN HTSISSLFER TCRQYDKLRK REAFLEQFRK EDIFKENFDE
     LDTSREIVQQ LIDEYHAATR PDYISWGTQE Q