TBG_CAEEL
ID TBG_CAEEL Reviewed; 444 AA.
AC P34475;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Tubulin gamma chain;
DE AltName: Full=Gamma-tubulin;
GN Name=tbg-1; ORFNames=F58A4.8;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11034903; DOI=10.1242/jcs.113.21.3747;
RA Bobinnec Y., Fukuda M., Nishida E.;
RT "Identification and characterization of Caenorhabditis elegans gamma-
RT tubulin in dividing cells and differentiated tissues.";
RL J. Cell Sci. 113:3747-3759(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [4]
RP SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=26586219; DOI=10.1242/dev.126615;
RA Quintin S., Wang S., Pontabry J., Bender A., Robin F., Hyenne V.,
RA Landmann F., Gally C., Oegema K., Labouesse M.;
RT "Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to
RT promote C. elegans elongation.";
RL Development 143:160-173(2016).
CC -!- FUNCTION: Tubulin is the major constituent of microtubules. The gamma
CC chain is found at microtubule organizing centers (MTOC) such as the
CC spindle poles or the centrosome, suggesting that it is involved in the
CC minus-end nucleation of microtubule assembly.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000305}. Cell junction, hemidesmosome
CC {ECO:0000269|PubMed:26586219}. Cell junction, adherens junction
CC {ECO:0000269|PubMed:26586219}.
CC -!- DEVELOPMENTAL STAGE: Expressed in between seam cells at the lima-bean,
CC 1.5-fold and 3-fold stages of embryonic development.
CC {ECO:0000269|PubMed:26586219}.
CC -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR EMBL; AF287259; AAG24513.1; -; mRNA.
DR EMBL; Z22179; CAA80164.1; -; Genomic_DNA.
DR PIR; S40980; S40980.
DR RefSeq; NP_499131.1; NM_066730.6.
DR AlphaFoldDB; P34475; -.
DR SMR; P34475; -.
DR BioGRID; 41556; 16.
DR DIP; DIP-26367N; -.
DR IntAct; P34475; 5.
DR STRING; 6239.F58A4.8; -.
DR EPD; P34475; -.
DR PaxDb; P34475; -.
DR PeptideAtlas; P34475; -.
DR EnsemblMetazoa; F58A4.8.1; F58A4.8.1; WBGene00006540.
DR GeneID; 176361; -.
DR KEGG; cel:CELE_F58A4.8; -.
DR UCSC; F58A4.8.1; c. elegans.
DR CTD; 176361; -.
DR WormBase; F58A4.8; CE00224; WBGene00006540; tbg-1.
DR eggNOG; KOG1374; Eukaryota.
DR GeneTree; ENSGT00940000174463; -.
DR HOGENOM; CLU_015718_1_0_1; -.
DR InParanoid; P34475; -.
DR OMA; EHGINKE; -.
DR OrthoDB; 687389at2759; -.
DR PhylomeDB; P34475; -.
DR SignaLink; P34475; -.
DR PRO; PR:P34475; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00006540; Expressed in adult organism and 4 other tissues.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR GO; GO:0030056; C:hemidesmosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005819; C:spindle; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; ISS:WormBase.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR GO; GO:0016048; P:detection of temperature stimulus; IGI:UniProtKB.
DR GO; GO:0051661; P:maintenance of centrosome location; IGI:UniProtKB.
DR GO; GO:0000212; P:meiotic spindle organization; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007020; P:microtubule nucleation; IMP:WormBase.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; IMP:WormBase.
DR GO; GO:0007052; P:mitotic spindle organization; IMP:WormBase.
DR GO; GO:0009794; P:regulation of mitotic cell cycle, embryonic; IGI:UniProtKB.
DR GO; GO:1903436; P:regulation of mitotic cytokinetic process; IGI:UniProtKB.
DR CDD; cd02188; gamma_tubulin; 1.
DR Gene3D; 1.10.287.600; -; 1.
DR Gene3D; 3.30.1330.20; -; 1.
DR Gene3D; 3.40.50.1440; -; 1.
DR InterPro; IPR002454; Gamma_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; PTHR11588; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01164; GAMMATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SUPFAM; SSF52490; SSF52490; 1.
DR SUPFAM; SSF55307; SSF55307; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cytoplasm; Cytoskeleton; GTP-binding; Microtubule;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..444
FT /note="Tubulin gamma chain"
FT /id="PRO_0000048448"
FT BINDING 144..150
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
SQ SEQUENCE 444 AA; 49929 MW; F96CB905B014D6A3 CRC64;
MSGTGALMTV HVGQCGNQLA QAFWKSMVDE HGINERGQTT HEDDMNDKKD LLFYQADDDH
YVPRAVLVDL EPRVINGMMQ SPNFSNLFNT DNIFMSDHGG GAGNNWASGY CQGQEVQEKI
MDIIIREAEN TNNLDGILFT HSVSGGTGSG TGSLLLERLR EAFPKKVIQT YSVFANSDTS
TDVVVHPYNW VLSMQRLIEN PDHVVVLDNA ALHRLAAGKF KTDTPTFDHI NSLVARIMST
STAPYRFNSA MCPSIRYLDL APFPPMHFIQ SAISPVVDPN ENFTRKTSVA DVTRFLLKPT
SMMVSTASRV RPNDCMLSAY MFLQGQIEAH TIMTAEQNVD FAIRRPPFYM LKPLRMMHAP
LSPYVRPQYK VSGLLLNNST SVAPLFESLL SKYDKLRSKR AFIDKFEKID NFSLDMMDDA
MHIVQDLLDE YKAVVQKDYL TRGL
