ID   TBG_NEUCR               Reviewed;         461 AA.
AC   P53377; Q7RV77; V5ILK0;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Tubulin gamma chain;
DE   AltName: Full=Gamma-tubulin;
GN   Name=tbg; Synonyms=tub4; ORFNames=G17A4.160, NCU03954;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9358070; DOI=10.1016/s0378-1119(97)00410-1;
RA   Heckmann S., Schliwa M., Kube-Granderath E.;
RT   "Primary structure of Neurospora crassa gamma-tubulin.";
RL   Gene 199:303-309(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Tubulin is the major constituent of microtubules. The gamma
CC       chain is found at microtubule organizing centers (MTOC) such as the
CC       spindle poles or the centrosome, suggesting that it is involved in the
CC       minus-end nucleation of microtubule assembly.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, spindle pole body {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR   EMBL; X97753; CAA66348.1; -; mRNA.
DR   EMBL; BX908812; CAF06151.1; -; Genomic_DNA.
DR   EMBL; CM002241; ESA42244.1; -; Genomic_DNA.
DR   EMBL; CM002241; ESA42245.1; -; Genomic_DNA.
DR   RefSeq; XP_011394889.1; XM_011396587.1.
DR   RefSeq; XP_011394890.1; XM_011396588.1.
DR   AlphaFoldDB; P53377; -.
DR   SMR; P53377; -.
DR   STRING; 5141.EFNCRP00000003724; -.
DR   PRIDE; P53377; -.
DR   EnsemblFungi; ESA42244; ESA42244; NCU03954.
DR   EnsemblFungi; ESA42245; ESA42245; NCU03954.
DR   GeneID; 3873683; -.
DR   KEGG; ncr:NCU03954; -.
DR   VEuPathDB; FungiDB:NCU03954; -.
DR   HOGENOM; CLU_015718_1_0_1; -.
DR   InParanoid; P53377; -.
DR   OMA; EHGINKE; -.
DR   Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0000923; C:equatorial microtubule organizing center; IEA:EnsemblFungi.
DR   GO; GO:0000930; C:gamma-tubulin complex; IBA:GO_Central.
DR   GO; GO:0061496; C:half bridge of mitotic spindle pole body; IEA:EnsemblFungi.
DR   GO; GO:0061497; C:inner plaque of mitotic spindle pole body; IEA:EnsemblFungi.
DR   GO; GO:0031021; C:interphase microtubule organizing center; IEA:EnsemblFungi.
DR   GO; GO:0043332; C:mating projection tip; IEA:EnsemblFungi.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0071957; C:old mitotic spindle pole body; IEA:EnsemblFungi.
DR   GO; GO:0061499; C:outer plaque of mitotic spindle pole body; IEA:EnsemblFungi.
DR   GO; GO:0005819; C:spindle; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR   GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:InterPro.
DR   GO; GO:0000212; P:meiotic spindle organization; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007020; P:microtubule nucleation; IBA:GO_Central.
DR   GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:1902408; P:mitotic cytokinesis, site selection; IEA:EnsemblFungi.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR   GO; GO:0051256; P:mitotic spindle midzone assembly; IEA:EnsemblFungi.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   CDD; cd02188; gamma_tubulin; 1.
DR   Gene3D; 1.10.287.600; -; 1.
DR   Gene3D; 3.30.1330.20; -; 1.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR002454; Gamma_tubulin.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR   InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR023123; Tubulin_C.
DR   InterPro; IPR017975; Tubulin_CS.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   Pfam; PF03953; Tubulin_C; 1.
DR   PRINTS; PR01164; GAMMATUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SMART; SM00864; Tubulin; 1.
DR   SMART; SM00865; Tubulin_C; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
DR   SUPFAM; SSF55307; SSF55307; 1.
DR   PROSITE; PS00227; TUBULIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..461
FT                   /note="Tubulin gamma chain"
FT                   /id="PRO_0000048474"
FT   BINDING         142..148
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   461 AA;  51598 MW;  70D0CBEA224B6343 CRC64;
     MPREIITIQA GQCGNSIGSQ FWQQLCLEHG ISQDGTIEDF ATEGGDRKDV FFYQSDDTRY
     IPRSILIDLE PRVINTIQTG PYRNIYNPEN FYVGKSGLGA GNNWGDGYQT GEQVHEEIME
     MIEREADGSD SLEGFMMLHS IAGGTGSGLG SFLLERLNDR FPKKIIQTYS VFPDTTSAGD
     VVVHPYNSLL AMRRLTQNAD SVVVLDNGAL SHIAADRLHV QEPSFQQTNQ LVSTVMSAST
     TTLRYPGYMH NDLVSILASL IPTPRCHFLM TSYTPFTGDQ VEQAKTVRKT TVLDVMRRLL
     QPKNRMVSTV PGKKSCYISI LNVIQGDVDP TDVHKSLLRI RERRLATFIP WGPASIQVAL
     TKRSPYVTMA HRVSGLMLAN HTSIATLFKR IVRQYDGMRK RNAFMEAYKK TAPFSENLNE
     FDEAREVVMD LIADYEAAED ANYLNPELGE NASADTDKRM A