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TBKB1_MOUSE
ID   TBKB1_MOUSE             Reviewed;         611 AA.
AC   A2A9T0; A2A9S9; Q6PFF1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=TANK-binding kinase 1-binding protein 1;
DE            Short=TBK1-binding protein 1;
DE   AltName: Full=Similar to NAP1 TBK1 adapter;
GN   Name=Tbkbp1 {ECO:0000312|MGI:MGI:1920424};
GN   Synonyms=Sintbad {ECO:0000303|PubMed:17568778};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:AAH57590.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:AAH57590.1};
RC   TISSUE=Brain {ECO:0000312|EMBL:AAH57590.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH TBK1 AND IKBKE, AND HOMODIMER.
RX   PubMed=17568778; DOI=10.1038/sj.emboj.7601743;
RA   Ryzhakov G., Randow F.;
RT   "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-
RT   binding domain with NAP1 and TANK.";
RL   EMBO J. 26:3180-3190(2007).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-400, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Lung;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Adapter protein which constitutively binds TBK1 and IKBKE
CC       playing a role in antiviral innate immunity. Essential for the
CC       efficient induction of IRF-dependent transcription following infection
CC       with Sendai virus. {ECO:0000269|PubMed:17568778}.
CC   -!- SUBUNIT: Homodimer (PubMed:17568778). May form a heterodimer with NAP1.
CC       Interacts with TKB1 and IKBKE (PubMed:17568778). Weakly interacts with
CC       DDX3X (By similarity). {ECO:0000250|UniProtKB:A7MCY6,
CC       ECO:0000269|PubMed:17568778}.
CC   -!- INTERACTION:
CC       A2A9T0; Q9WUN2: Tbk1; NbExp=2; IntAct=EBI-7987134, EBI-764193;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A2A9T0-1; Sequence=Displayed;
CC       Name=2 {ECO:0000269|PubMed:15489334};
CC         IsoId=A2A9T0-2; Sequence=VSP_032344, VSP_052716;
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DR   EMBL; AL627445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC057590; AAH57590.1; -; mRNA.
DR   CCDS; CCDS88239.1; -. [A2A9T0-1]
DR   RefSeq; NP_932768.2; NM_198100.2.
DR   RefSeq; XP_006534398.1; XM_006534335.1.
DR   RefSeq; XP_006534399.1; XM_006534336.2.
DR   RefSeq; XP_006534400.1; XM_006534337.2.
DR   AlphaFoldDB; A2A9T0; -.
DR   SMR; A2A9T0; -.
DR   BioGRID; 215817; 4.
DR   IntAct; A2A9T0; 1.
DR   MINT; A2A9T0; -.
DR   STRING; 10090.ENSMUSP00000103240; -.
DR   iPTMnet; A2A9T0; -.
DR   PhosphoSitePlus; A2A9T0; -.
DR   EPD; A2A9T0; -.
DR   MaxQB; A2A9T0; -.
DR   PaxDb; A2A9T0; -.
DR   PRIDE; A2A9T0; -.
DR   ProteomicsDB; 254830; -. [A2A9T0-1]
DR   ProteomicsDB; 254831; -. [A2A9T0-2]
DR   Antibodypedia; 30174; 159 antibodies from 27 providers.
DR   DNASU; 73174; -.
DR   Ensembl; ENSMUST00000066078; ENSMUSP00000065461; ENSMUSG00000038517. [A2A9T0-1]
DR   Ensembl; ENSMUST00000107614; ENSMUSP00000103239; ENSMUSG00000038517. [A2A9T0-1]
DR   GeneID; 73174; -.
DR   KEGG; mmu:73174; -.
DR   CTD; 9755; -.
DR   MGI; MGI:1920424; Tbkbp1.
DR   VEuPathDB; HostDB:ENSMUSG00000038517; -.
DR   eggNOG; ENOG502QVP4; Eukaryota.
DR   GeneTree; ENSGT00940000153704; -.
DR   InParanoid; A2A9T0; -.
DR   OMA; QRHSPIQ; -.
DR   OrthoDB; 621943at2759; -.
DR   PhylomeDB; A2A9T0; -.
DR   TreeFam; TF331289; -.
DR   BioGRID-ORCS; 73174; 5 hits in 72 CRISPR screens.
DR   PRO; PR:A2A9T0; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; A2A9T0; protein.
DR   Bgee; ENSMUSG00000038517; Expressed in granulocyte and 183 other tissues.
DR   ExpressionAtlas; A2A9T0; baseline and differential.
DR   Genevisible; A2A9T0; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR   InterPro; IPR024581; TBD.
DR   Pfam; PF12845; TBD; 1.
DR   PROSITE; PS51905; ZF_UBZ1; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Immunity; Innate immunity;
KW   Metal-binding; Phosphoprotein; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..611
FT                   /note="TANK-binding kinase 1-binding protein 1"
FT                   /id="PRO_0000324655"
FT   ZN_FING         579..605
FT                   /note="UBZ1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT   REGION          1..280
FT                   /note="Homodimerization"
FT   REGION          281..330
FT                   /note="Interaction with TBK1 and IKBKE"
FT                   /evidence="ECO:0000269|PubMed:17568778"
FT   REGION          328..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          48..162
FT                   /evidence="ECO:0000255"
FT   COILED          218..277
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        328..343
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..435
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         582
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT   BINDING         585
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT   BINDING         601
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT   BINDING         605
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01253"
FT   MOD_RES         184
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A7MCY6"
FT   MOD_RES         365
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A7MCY6"
FT   MOD_RES         372
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A7MCY6"
FT   MOD_RES         379
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A7MCY6"
FT   MOD_RES         385
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A7MCY6"
FT   MOD_RES         400
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         415
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A7MCY6"
FT   MOD_RES         500
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A7MCY6"
FT   MOD_RES         530
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A7MCY6"
FT   VAR_SEQ         212
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_032344"
FT   VAR_SEQ         364..377
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_052716"
SQ   SEQUENCE   611 AA;  67001 MW;  B2AF8DF98F1C6EF9 CRC64;
     MESMFEDDIS ILTQEALGPS EVWLDGPGDP SLGGDMCSAS HFALITAYGD IKERLGGLER
     ENATLRRRLK VYEIKYPLIT DFGEEHGFPL YELKDGSLLE VEKVSLQQRL NQFQHELQKS
     KEQEEQLGEM IQAYEKLCVE KSDLETELGE MRALVETHLR QICGLEKQLQ QQQGLRDAAF
     SSLSPPAVPA SACPDLDLHY LALRGGPALG HAGWPGPTSV SVSELERRRL EEALEAAQGE
     ARGAQLREEQ LQAECERLQG ELKQLQETRA QDLASNQSEC DMAWVKRVGD DQVNLALAYT
     ELTEELGRLR ELSSLQGRIL RTLLQEQARN AGQRHSPLSQ RHSPAPACPS PSPPARPPPC
     APCQSPAAQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS PVPPSCQSPS PQRRSPVPPS
     CPAPQPRPPP PPGERTLAER VYAKPPSHHA KAGFQGRRSY SELAEGAAYA GASPAWLQAE
     AATLPKPRAY GGELYGRPLS PRRAFEGIRL RFEKQPSEEE EWAMPASPPS PEAGTIRCAS
     FCAGFPIPES PAATAYAHAE HAQSWPSINL LMETVGSDIR SCPLCQLGFP VGYPDDALIK
     HIDSHLENSK I
 
 
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