TBL2_MOUSE
ID TBL2_MOUSE Reviewed; 442 AA.
AC Q9R099; Q8CFY0;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Transducin beta-like protein 2;
GN Name=Tbl2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10575226; DOI=10.1159/000015319;
RA Perez Jurado L.A., Wang Y.-K., Francke U., Cruces J.;
RT "TBL2, a novel transducin family member in the WBS deletion:
RT characterization of the complete sequence, genomic structure,
RT transcriptional variants and the mouse ortholog.";
RL Cytogenet. Cell Genet. 86:277-284(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AF097523; AAF06825.1; -; mRNA.
DR EMBL; AK132366; BAE21128.1; -; mRNA.
DR EMBL; AK165686; BAE38338.1; -; mRNA.
DR EMBL; BC039273; AAH39273.1; -; mRNA.
DR EMBL; BC048185; AAH48185.1; -; mRNA.
DR CCDS; CCDS19735.1; -.
DR RefSeq; NP_038791.2; NM_013763.2.
DR AlphaFoldDB; Q9R099; -.
DR SMR; Q9R099; -.
DR BioGRID; 205175; 4.
DR IntAct; Q9R099; 1.
DR STRING; 10090.ENSMUSP00000115011; -.
DR iPTMnet; Q9R099; -.
DR PhosphoSitePlus; Q9R099; -.
DR SwissPalm; Q9R099; -.
DR EPD; Q9R099; -.
DR jPOST; Q9R099; -.
DR MaxQB; Q9R099; -.
DR PaxDb; Q9R099; -.
DR PRIDE; Q9R099; -.
DR ProteomicsDB; 254667; -.
DR Antibodypedia; 2315; 193 antibodies from 27 providers.
DR DNASU; 27368; -.
DR Ensembl; ENSMUST00000153183; ENSMUSP00000115011; ENSMUSG00000005374.
DR GeneID; 27368; -.
DR KEGG; mmu:27368; -.
DR UCSC; uc008zxu.1; mouse.
DR CTD; 26608; -.
DR MGI; MGI:1351652; Tbl2.
DR VEuPathDB; HostDB:ENSMUSG00000005374; -.
DR eggNOG; KOG2096; Eukaryota.
DR GeneTree; ENSGT00390000013836; -.
DR HOGENOM; CLU_047173_1_0_1; -.
DR InParanoid; Q9R099; -.
DR OMA; WDINVRY; -.
DR OrthoDB; 778808at2759; -.
DR PhylomeDB; Q9R099; -.
DR TreeFam; TF315054; -.
DR BioGRID-ORCS; 27368; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Tbl2; mouse.
DR PRO; PR:Q9R099; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9R099; protein.
DR Bgee; ENSMUSG00000005374; Expressed in spermatocyte and 233 other tissues.
DR ExpressionAtlas; Q9R099; baseline and differential.
DR Genevisible; Q9R099; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0051219; F:phosphoprotein binding; ISO:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0031369; F:translation initiation factor binding; ISO:MGI.
DR GO; GO:0042149; P:cellular response to glucose starvation; ISO:MGI.
DR GO; GO:0071456; P:cellular response to hypoxia; ISO:MGI.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; ISO:MGI.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR042410; WBSCR13.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR44321; PTHR44321; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Isopeptide bond; Phosphoprotein; Reference proteome; Repeat;
KW Ubl conjugation; WD repeat.
FT CHAIN 1..442
FT /note="Transducin beta-like protein 2"
FT /id="PRO_0000051271"
FT REPEAT 84..123
FT /note="WD 1"
FT REPEAT 130..170
FT /note="WD 2"
FT REPEAT 182..222
FT /note="WD 3"
FT REPEAT 224..263
FT /note="WD 4"
FT REPEAT 273..312
FT /note="WD 5"
FT REPEAT 323..362
FT /note="WD 6"
FT REPEAT 366..404
FT /note="WD 7"
FT REGION 36..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 428
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y4P3"
FT CROSSLNK 164
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9Y4P3"
FT CONFLICT 156
FT /note="T -> S (in Ref. 1; AAF06825)"
FT /evidence="ECO:0000305"
FT CONFLICT 357
FT /note="G -> A (in Ref. 1; AAF06825)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 442 AA; 49584 MW; 483685E07C66BA40 CRC64;
MELPQMPELM GLSLLVGLLA LVATAAVARG WLRAEEKPSQ PVCQKENEPK KSGSKKQKQN
QRVRKEKPQQ HSFTHPLLAA ALKSHSGNIS CMDFSSNGKY LATCADDRTV RIWSTKDFLQ
REHRSMRANV ELDHATLVRF SPDCRAFIVW LANGDTLRVF KMTKREDGGF TFTATPEDFP
KKHKAPIINI GIADTGKFIM TASSDTTVLI WNLKGQVLST INTNQMNNSH AVISPCSRFV
GSCGFTPDVK VWEVCFGKKG EFQEVLRAFE LKGHSASVHS FAFSNDSRRM ASVSKDGTWK
LWDTDVEYKK QQDPYLLRTG RFEEASTMPC RLALSPDTHV LALATGTNIH LFNTRRGEKE
EYFECVHGEC IADLTFDITG RFLASCGDRA VRLFHNTPGH RAVVEEMQSL LKRASSESTR
QRLQQQLTQA QEALKSLGAL KK
