TBL3_MOUSE
ID TBL3_MOUSE Reviewed; 801 AA.
AC Q8C4J7; Q3TNP3; Q3UDS9; Q8VE90;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Transducin beta-like protein 3;
GN Name=Tbl3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone, Bone marrow, Head, and Ovary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
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DR EMBL; AK081966; BAC38381.1; -; mRNA.
DR EMBL; AK137554; BAE23405.1; -; mRNA.
DR EMBL; AK149940; BAE29182.1; -; mRNA.
DR EMBL; AK165125; BAE38045.1; -; mRNA.
DR EMBL; BC019504; AAH19504.1; -; mRNA.
DR CCDS; CCDS28493.1; -.
DR RefSeq; NP_663371.2; NM_145396.4.
DR AlphaFoldDB; Q8C4J7; -.
DR SMR; Q8C4J7; -.
DR BioGRID; 229469; 5.
DR STRING; 10090.ENSMUSP00000120911; -.
DR iPTMnet; Q8C4J7; -.
DR PhosphoSitePlus; Q8C4J7; -.
DR SwissPalm; Q8C4J7; -.
DR EPD; Q8C4J7; -.
DR MaxQB; Q8C4J7; -.
DR PaxDb; Q8C4J7; -.
DR PeptideAtlas; Q8C4J7; -.
DR PRIDE; Q8C4J7; -.
DR ProteomicsDB; 259360; -.
DR Antibodypedia; 23366; 75 antibodies from 17 providers.
DR DNASU; 213773; -.
DR Ensembl; ENSMUST00000126319; ENSMUSP00000120911; ENSMUSG00000040688.
DR GeneID; 213773; -.
DR KEGG; mmu:213773; -.
DR UCSC; uc008axv.1; mouse.
DR CTD; 10607; -.
DR MGI; MGI:2384863; Tbl3.
DR VEuPathDB; HostDB:ENSMUSG00000040688; -.
DR eggNOG; KOG0319; Eukaryota.
DR GeneTree; ENSGT00940000157651; -.
DR HOGENOM; CLU_009276_1_0_1; -.
DR InParanoid; Q8C4J7; -.
DR OMA; PYVQRHF; -.
DR OrthoDB; 1112002at2759; -.
DR PhylomeDB; Q8C4J7; -.
DR TreeFam; TF314872; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 213773; 29 hits in 76 CRISPR screens.
DR ChiTaRS; Tbl3; mouse.
DR PRO; PR:Q8C4J7; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8C4J7; protein.
DR Bgee; ENSMUSG00000040688; Expressed in spermatocyte and 235 other tissues.
DR ExpressionAtlas; Q8C4J7; baseline and differential.
DR Genevisible; Q8C4J7; MM.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; IEA:InterPro.
DR GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 4.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR013934; SSU_processome_Utp13.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF08625; Utp13; 1.
DR Pfam; PF00400; WD40; 9.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 13.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 9.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Ubl conjugation; WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q12788"
FT CHAIN 2..801
FT /note="Transducin beta-like protein 3"
FT /id="PRO_0000362980"
FT REPEAT 64..105
FT /note="WD 1"
FT REPEAT 107..146
FT /note="WD 2"
FT REPEAT 149..190
FT /note="WD 3"
FT REPEAT 193..232
FT /note="WD 4"
FT REPEAT 245..284
FT /note="WD 5"
FT REPEAT 290..329
FT /note="WD 6"
FT REPEAT 332..372
FT /note="WD 7"
FT REPEAT 374..413
FT /note="WD 8"
FT REPEAT 419..459
FT /note="WD 9"
FT REPEAT 477..516
FT /note="WD 10"
FT REPEAT 519..560
FT /note="WD 11"
FT REPEAT 562..602
FT /note="WD 12"
FT REPEAT 604..642
FT /note="WD 13"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q12788"
FT MOD_RES 257
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q12788"
FT CROSSLNK 407
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q12788"
FT CONFLICT 18
FT /note="E -> G (in Ref. 1; BAE29182)"
FT /evidence="ECO:0000305"
FT CONFLICT 457
FT /note="A -> AN (in Ref. 2; AAH19504)"
FT /evidence="ECO:0000305"
FT CONFLICT 475
FT /note="R -> Q (in Ref. 2; AAH19504)"
FT /evidence="ECO:0000305"
FT CONFLICT 483
FT /note="N -> K (in Ref. 1; BAE38045)"
FT /evidence="ECO:0000305"
FT CONFLICT 797
FT /note="A -> V (in Ref. 2; AAH19504)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 801 AA; 88266 MW; 1B5AEE0CCB3D1B3D CRC64;
MAETAAGLCR FKANYAVERK IEPFYKGGKA QLDQTGHYLF CVCGTKVNIL DVASGALLRS
LEQEDQEDIT SFDLSPDDEV LVTASRALLL AQWAWREGTV TRLWKAIHTA PVASMAFDAT
STLLATGGCD GAVRVWDIVQ HYGTHHFRGS PGVVHLVAFH PDPTRLLLFS SAVDTSIRVW
SLQDRSCLAV LTAHYSAVTS LSFSEGGHTM LSSGRDKICI VWDLQSYQTT RTVPVFESVE
ASVLLPEQPA PALGVKSSGL HFLTAGDQGI LRVWEAASGQ CVYTQPQMPG LRQELTHCTL
ARAADLLLTV TADHNLLLYE AHSLQLQKQF AGYSEEVLDV RFLGPSDSHI VVASNSPCLK
VFELQTLACQ ILHGHTDIVL ALDVFRKGWL FASCAKDQSI RIWKMNKAGQ VACVAQGSGH
THSVGTICCS RLKESFLVTG SQDCTVKLWP LPEALLAKST AADSGPVLLQ AQTTRRCHDK
DINSLAVSPN DKLLATGSQD RTAKLWALPQ CQLLGVFTGH RRGLWNVQFS PTDQVLATAS
ADGTIKLWAL QDFSCLKTFE GHDASVLKVA FVSRGSQLLS SGSDGLLKLW TIKSNECVRT
LDAHEDKVWG LHCSQLDDHA ITGGSDSRII LWKDVTEAEQ AEEQAKREEQ VIKQQELDNL
LHEKRYLRAL GLAISLDRPH TVLTVIQAIR RDPEACEKLE ATVLRLRRDQ KEALLRFCVT
WNTNSRHCHE AQAVLGVLLR HEAPEELLAY DGVRGSLEAL LPYTERHFQR LSRTLQAATF
LDFLWHNMKL SPCPAAAPPA L
