TBL40_ARATH
ID TBL40_ARATH Reviewed; 364 AA.
AC Q67XC4; F4IPX4; F4IPX5; O82273; Q84W32; Q8LAX5;
DT 19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT 19-FEB-2014, sequence version 2.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Protein trichome birefringence-like 40;
GN Name=TBL40; OrderedLocusNames=At2g31110; ORFNames=T16B12.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-364 (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=17316173; DOI=10.1111/j.1365-313x.2006.02994.x;
RA Xin Z., Mandaokar A., Chen J., Last R.L., Browse J.;
RT "Arabidopsis ESK1 encodes a novel regulator of freezing tolerance.";
RL Plant J. 49:786-799(2007).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20388664; DOI=10.1104/pp.110.153320;
RA Bischoff V., Nita S., Neumetzler L., Schindelasch D., Urbain A., Eshed R.,
RA Persson S., Delmer D., Scheible W.R.;
RT "TRICHOME BIREFRINGENCE and its homolog AT5G01360 encode plant-specific
RT DUF231 proteins required for cellulose biosynthesis in Arabidopsis.";
RL Plant Physiol. 153:590-602(2010).
RN [8]
RP 3D-STRUCTURE MODELING.
RX PubMed=20657172; DOI=10.4161/psb.5.8.12414;
RA Bischoff V., Selbig J., Scheible W.R.;
RT "Involvement of TBL/DUF231 proteins into cell wall biology.";
RL Plant Signal. Behav. 5:1057-1059(2010).
CC -!- FUNCTION: May act as a bridging protein that binds pectin and other
CC cell wall polysaccharides. Probably involved in maintaining
CC esterification of pectins (By similarity). May be involved in the
CC specific O-acetylation of cell wall polymers (By similarity).
CC {ECO:0000250|UniProtKB:Q9FG35, ECO:0000250|UniProtKB:Q9LY46}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q67XC4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q67XC4-2; Sequence=VSP_053695;
CC -!- MISCELLANEOUS: Contains 2 motifs that are conserved in esterases, but
CC it is unlikely that this protein belongs to the catalytically active
CC pectin esterases. {ECO:0000305|PubMed:20657172}.
CC -!- SIMILARITY: Belongs to the PC-esterase family. TBL subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC63848.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005311; AAC63848.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08494.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08495.1; -; Genomic_DNA.
DR EMBL; AK176895; BAD44658.1; -; mRNA.
DR EMBL; AY087549; AAM65091.1; -; mRNA.
DR EMBL; BT004296; AAO42294.1; -; mRNA.
DR PIR; F84716; F84716.
DR RefSeq; NP_001077985.1; NM_001084516.2. [Q67XC4-1]
DR RefSeq; NP_180669.2; NM_128667.2. [Q67XC4-2]
DR AlphaFoldDB; Q67XC4; -.
DR SMR; Q67XC4; -.
DR STRING; 3702.AT2G31110.2; -.
DR PaxDb; Q67XC4; -.
DR PRIDE; Q67XC4; -.
DR ProteomicsDB; 234264; -. [Q67XC4-1]
DR EnsemblPlants; AT2G31110.1; AT2G31110.1; AT2G31110. [Q67XC4-2]
DR EnsemblPlants; AT2G31110.2; AT2G31110.2; AT2G31110. [Q67XC4-1]
DR GeneID; 817667; -.
DR Gramene; AT2G31110.1; AT2G31110.1; AT2G31110. [Q67XC4-2]
DR Gramene; AT2G31110.2; AT2G31110.2; AT2G31110. [Q67XC4-1]
DR KEGG; ath:AT2G31110; -.
DR Araport; AT2G31110; -.
DR TAIR; locus:2055878; AT2G31110.
DR eggNOG; ENOG502QQWH; Eukaryota.
DR OMA; TRSCKSE; -.
DR PRO; PR:Q67XC4; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q67XC4; baseline and differential.
DR Genevisible; Q67XC4; AT.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016413; F:O-acetyltransferase activity; IBA:GO_Central.
DR InterPro; IPR026057; PC-Esterase.
DR InterPro; IPR029962; TBL.
DR InterPro; IPR025846; TBL_N.
DR PANTHER; PTHR32285; PTHR32285; 1.
DR Pfam; PF13839; PC-Esterase; 1.
DR Pfam; PF14416; PMR5N; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..364
FT /note="Protein trichome birefringence-like 40"
FT /id="PRO_0000425405"
FT TRANSMEM 9..25
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT MOTIF 118..120
FT /note="GDS motif"
FT MOTIF 341..355
FT /note="DCXHWCLPGXXDXWN motif"
FT VAR_SEQ 1..156
FT /note="MGLCFQLNLASLSLILFSSFPGLLAQSQQHFLGQNNTSLLSGGRCNLARGKW
FT VYDSSYPLYSAFSCPFIDSEFNCQKAGRPDTNYQHFRWQPFSCPLPRFDGANFMRRMRG
FT KKIMMVGDSLSLNMFESLACLLHASLPNAKYSLRRSQPLTSLTFQ -> MTVKPKEK
FT (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_053695"
FT CONFLICT 2
FT /note="G -> V (in Ref. 4; AAM65091)"
FT /evidence="ECO:0000305"
FT CONFLICT 233
FT /note="V -> M (in Ref. 3; BAD44658)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 364 AA; 41768 MW; 6F03BC7BCF0BE93B CRC64;
MGLCFQLNLA SLSLILFSSF PGLLAQSQQH FLGQNNTSLL SGGRCNLARG KWVYDSSYPL
YSAFSCPFID SEFNCQKAGR PDTNYQHFRW QPFSCPLPRF DGANFMRRMR GKKIMMVGDS
LSLNMFESLA CLLHASLPNA KYSLRRSQPL TSLTFQDYGV TINLYRTQFL VDVVQEKAGR
VLVLDSIKQA DAWLGMDVLI FNSWHWWTHT SGLQPWDYMR EGNQLYKDMN RLVAYYKGLN
TWARWINNNI VPSRTQVFFQ GVSPVHYDGR EWNEPLKSCN GQTQPFMGQR YPGGLPLGWV
VVNKVLSRIR KPVHLLDLTT LSEYRKDAHP SLYNGISKDL DCSHWCLPGL PDTWNLLLYS
SLTS