TBL43_ARATH
ID TBL43_ARATH Reviewed; 368 AA.
AC Q6DR10; O80855; Q84N42; Q84N43;
DT 19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Protein trichome birefringence-like 43;
GN Name=TBL43; OrderedLocusNames=At2g30900; ORFNames=AT1G29050.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=cv. Columbia;
RX PubMed=16244158; DOI=10.1104/pp.105.063479;
RA Xiao Y.-L., Smith S.R., Ishmael N., Redman J.C., Kumar N., Monaghan E.L.,
RA Ayele M., Haas B.J., Wu H.C., Town C.D.;
RT "Analysis of the cDNAs of hypothetical genes on Arabidopsis chromosome 2
RT reveals numerous transcript variants.";
RL Plant Physiol. 139:1323-1337(2005).
RN [5]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=17316173; DOI=10.1111/j.1365-313x.2006.02994.x;
RA Xin Z., Mandaokar A., Chen J., Last R.L., Browse J.;
RT "Arabidopsis ESK1 encodes a novel regulator of freezing tolerance.";
RL Plant J. 49:786-799(2007).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20388664; DOI=10.1104/pp.110.153320;
RA Bischoff V., Nita S., Neumetzler L., Schindelasch D., Urbain A., Eshed R.,
RA Persson S., Delmer D., Scheible W.R.;
RT "TRICHOME BIREFRINGENCE and its homolog AT5G01360 encode plant-specific
RT DUF231 proteins required for cellulose biosynthesis in Arabidopsis.";
RL Plant Physiol. 153:590-602(2010).
RN [7]
RP 3D-STRUCTURE MODELING.
RX PubMed=20657172; DOI=10.4161/psb.5.8.12414;
RA Bischoff V., Selbig J., Scheible W.R.;
RT "Involvement of TBL/DUF231 proteins into cell wall biology.";
RL Plant Signal. Behav. 5:1057-1059(2010).
CC -!- FUNCTION: May act as a bridging protein that binds pectin and other
CC cell wall polysaccharides. Probably involved in maintaining
CC esterification of pectins (By similarity). May be involved in the
CC specific O-acetylation of cell wall polymers (By similarity).
CC {ECO:0000250|UniProtKB:Q9FG35, ECO:0000250|UniProtKB:Q9LY46}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6DR10-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6DR10-2; Sequence=VSP_053699;
CC -!- MISCELLANEOUS: Contains 2 motifs that are conserved in esterases, but
CC it is unlikely that this protein belongs to the catalytically active
CC pectin esterases. {ECO:0000305|PubMed:20657172}.
CC -!- SIMILARITY: Belongs to the PC-esterase family. TBL subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC20724.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAP22495.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC004669; AAC20724.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002685; AEC08454.1; -; Genomic_DNA.
DR EMBL; AY649305; AAT69222.1; -; mRNA.
DR EMBL; AY262050; AAP22494.1; -; mRNA.
DR EMBL; AY262051; AAP22495.1; ALT_INIT; mRNA.
DR PIR; A84714; A84714.
DR RefSeq; NP_180647.2; NM_128642.2. [Q6DR10-1]
DR AlphaFoldDB; Q6DR10; -.
DR SMR; Q6DR10; -.
DR STRING; 3702.AT2G30900.1; -.
DR iPTMnet; Q6DR10; -.
DR PaxDb; Q6DR10; -.
DR PRIDE; Q6DR10; -.
DR ProteomicsDB; 234136; -. [Q6DR10-1]
DR EnsemblPlants; AT2G30900.1; AT2G30900.1; AT2G30900. [Q6DR10-1]
DR GeneID; 817640; -.
DR Gramene; AT2G30900.1; AT2G30900.1; AT2G30900. [Q6DR10-1]
DR KEGG; ath:AT2G30900; -.
DR Araport; AT2G30900; -.
DR TAIR; locus:2052856; AT2G30900.
DR eggNOG; ENOG502QVJM; Eukaryota.
DR HOGENOM; CLU_020953_3_0_1; -.
DR InParanoid; Q6DR10; -.
DR OMA; CNITRFN; -.
DR OrthoDB; 730219at2759; -.
DR PhylomeDB; Q6DR10; -.
DR PRO; PR:Q6DR10; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q6DR10; baseline and differential.
DR Genevisible; Q6DR10; AT.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016413; F:O-acetyltransferase activity; IBA:GO_Central.
DR InterPro; IPR026057; PC-Esterase.
DR InterPro; IPR029962; TBL.
DR InterPro; IPR025846; TBL_N.
DR PANTHER; PTHR32285; PTHR32285; 1.
DR Pfam; PF13839; PC-Esterase; 1.
DR Pfam; PF14416; PMR5N; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..368
FT /note="Protein trichome birefringence-like 43"
FT /id="PRO_0000425408"
FT TRANSMEM 9..25
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT MOTIF 117..119
FT /note="GDS motif"
FT MOTIF 344..358
FT /note="DCXHWCLPGXXDXWN motif"
FT VAR_SEQ 216..368
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16244158"
FT /id="VSP_053699"
FT CONFLICT 205
FT /note="H -> R (in Ref. 4; AAP22494/AAP22495)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 368 AA; 41248 MW; 8CB29EEB50FAA811 CRC64;
MMRGAAPTGV VSVMVLMILV LLKQIESASA NGSSLGLPPR KFCNIYQGSW VYDKSYPLYD
SKNCPFIERQ FNCKSNGRPD SEYLKYRWQP SGCNLPRFNG LDFLGRIMKG KKLMFVGDSL
SLNQWQSLTC LLHNAAPKAN STSTRSPSGL SVFSFPAYNS SIMFSRNAFL VDIVGAPPKR
VMKLDSISSG SLWKTADVLV FNSWHWWLHT DRKQPWDAIM SGNVTVKDMD RLVAYEKAMM
TWAKWIDQNI DPSKTKVFFQ GISPDHGRAR EWSKQGGKGS CIGETKPIMG SSYLAGPHAA
EMVVAKVIKT MKNQARLMDV TLMSQLRKDG HPSVYGFGGH RMADCSHWCL SGVPDSWNQL
LYSELFHS
