TBL4_ARATH
ID TBL4_ARATH Reviewed; 457 AA.
AC Q9FJ06;
DT 19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Protein trichome birefringence-like 4;
GN Name=TBL4; OrderedLocusNames=At5g49340; ORFNames=K21P3.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=17316173; DOI=10.1111/j.1365-313x.2006.02994.x;
RA Xin Z., Mandaokar A., Chen J., Last R.L., Browse J.;
RT "Arabidopsis ESK1 encodes a novel regulator of freezing tolerance.";
RL Plant J. 49:786-799(2007).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20388664; DOI=10.1104/pp.110.153320;
RA Bischoff V., Nita S., Neumetzler L., Schindelasch D., Urbain A., Eshed R.,
RA Persson S., Delmer D., Scheible W.R.;
RT "TRICHOME BIREFRINGENCE and its homolog AT5G01360 encode plant-specific
RT DUF231 proteins required for cellulose biosynthesis in Arabidopsis.";
RL Plant Physiol. 153:590-602(2010).
RN [6]
RP 3D-STRUCTURE MODELING.
RX PubMed=20657172; DOI=10.4161/psb.5.8.12414;
RA Bischoff V., Selbig J., Scheible W.R.;
RT "Involvement of TBL/DUF231 proteins into cell wall biology.";
RL Plant Signal. Behav. 5:1057-1059(2010).
CC -!- FUNCTION: May act as a bridging protein that binds pectin and other
CC cell wall polysaccharides. Probably involved in maintaining
CC esterification of pectins (By similarity). May be involved in the
CC specific O-acetylation of cell wall polymers (By similarity).
CC {ECO:0000250|UniProtKB:Q9FG35, ECO:0000250|UniProtKB:Q9LY46}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Contains 2 motifs that are conserved in esterases, but
CC it is unlikely that this protein belongs to the catalytically active
CC pectin esterases. {ECO:0000305|PubMed:20657172}.
CC -!- SIMILARITY: Belongs to the PC-esterase family. TBL subfamily.
CC {ECO:0000305}.
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DR EMBL; AB016872; BAB10352.1; -; Genomic_DNA.
DR EMBL; AB023034; BAB10352.1; JOINED; Genomic_DNA.
DR EMBL; CP002688; AED95799.1; -; Genomic_DNA.
DR RefSeq; NP_199745.1; NM_124311.2.
DR AlphaFoldDB; Q9FJ06; -.
DR SMR; Q9FJ06; -.
DR PaxDb; Q9FJ06; -.
DR PRIDE; Q9FJ06; -.
DR EnsemblPlants; AT5G49340.1; AT5G49340.1; AT5G49340.
DR GeneID; 834994; -.
DR Gramene; AT5G49340.1; AT5G49340.1; AT5G49340.
DR KEGG; ath:AT5G49340; -.
DR Araport; AT5G49340; -.
DR TAIR; locus:2155874; AT5G49340.
DR eggNOG; ENOG502QSN1; Eukaryota.
DR HOGENOM; CLU_020953_0_2_1; -.
DR InParanoid; Q9FJ06; -.
DR OMA; FQEGSHV; -.
DR OrthoDB; 637009at2759; -.
DR PhylomeDB; Q9FJ06; -.
DR PRO; PR:Q9FJ06; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FJ06; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016413; F:O-acetyltransferase activity; IBA:GO_Central.
DR InterPro; IPR026057; PC-Esterase.
DR InterPro; IPR029962; TBL.
DR InterPro; IPR025846; TBL_N.
DR InterPro; IPR029989; TBR/TBL4.
DR PANTHER; PTHR32285; PTHR32285; 1.
DR PANTHER; PTHR32285:SF22; PTHR32285:SF22; 1.
DR Pfam; PF13839; PC-Esterase; 1.
DR Pfam; PF14416; PMR5N; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..457
FT /note="Protein trichome birefringence-like 4"
FT /id="PRO_0000425370"
FT TRANSMEM 19..37
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT MOTIF 173..175
FT /note="GDS motif"
FT MOTIF 420..434
FT /note="DCXHWCLPGXXDXWN motif"
SQ SEQUENCE 457 AA; 52302 MW; 3557BB97943E8912 CRC64;
MADLKNLFLI TKHPSTTQIF LTSLFFLSLF LLSSSSLSDF SPSLIVSSFT SRLLTAANFF
SSPSSYTSSA SDTTMFLSSV SPRRINEPKI DSETKELASC DIFDGTWVFD DSEPVYLPGY
CPFVEDKFNC FKNGRPDSGF LRHRWQPHGC SIPRFDGKKM LKMLRGKRVV FVGDSLNRNM
WESLVCSLRS TLEDKNRVSK IIGKQSNLPN EGFYGFRFND FECSIDFIKS PFLVQESEVV
DVYGKRRETL RLDMIQRSMT KIYKNADIVI FNTGHWWTHQ KTYEGKGYYQ EGNRVYERLE
VKEAYTKAIH TWADWVDSNI NSTKTRVFFV GYSSSHFRKG AWNSGGQCDG ETRPIQNETY
TGVYPWMMKV VESVISEMKT PVFYMNITKM TWYRTDGHPS VYRQPADPRG TSPAAGMYQD
CSHWCLPGVP DSWNQLLYAT LLVSHGSLPD KSLGSLL
