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TBP1_ENTHI
ID   TBP1_ENTHI              Reviewed;         234 AA.
AC   P52653; B1N4X3;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=TATA-box-binding protein 1;
DE            Short=EhTBP;
DE   AltName: Full=TATA sequence-binding protein;
DE   AltName: Full=TATA-binding factor;
DE   AltName: Full=TATA-box factor;
DE   AltName: Full=Transcription initiation factor TFIID TBP subunit;
GN   Name=TBP; ORFNames=EHI_020610;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 30459 / HM-1:IMSS;
RX   PubMed=9033007;
RA   Hernandez R., Luna-Arias J.P., Orozco E.;
RT   "Comparison of the Entamoeba histolytica TATA-binding protein (TBP)
RT   structure with other TBP.";
RL   Arch. Med. Res. 28:43-45(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 30459 / HM-1:IMSS;
RX   PubMed=15729342; DOI=10.1038/nature03291;
RA   Loftus B.J., Anderson I., Davies R., Alsmark U.C., Samuelson J., Amedeo P.,
RA   Roncaglia P., Berriman M., Hirt R.P., Mann B.J., Nozaki T., Suh B., Pop M.,
RA   Duchene M., Ackers J., Tannich E., Leippe M., Hofer M., Bruchhaus I.,
RA   Willhoeft U., Bhattacharya A., Chillingworth T., Churcher C.M., Hance Z.,
RA   Harris B., Harris D., Jagels K., Moule S., Mungall K.L., Ormond D.,
RA   Squares R., Whitehead S., Quail M.A., Rabbinowitsch E., Norbertczak H.,
RA   Price C., Wang Z., Guillen N., Gilchrist C., Stroup S.E., Bhattacharya S.,
RA   Lohia A., Foster P.G., Sicheritz-Ponten T., Weber C., Singh U.,
RA   Mukherjee C., El-Sayed N.M.A., Petri W.A., Clark C.G., Embley T.M.,
RA   Barrell B.G., Fraser C.M., Hall N.;
RT   "The genome of the protist parasite Entamoeba histolytica.";
RL   Nature 433:865-868(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 30459 / HM-1:IMSS;
RA   Lorenzi H., Amedeo P., Inman J., Schobel S., Caler E.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION.
RX   PubMed=20026212; DOI=10.1016/j.pep.2009.12.007;
RA   Castanon-Sanchez C.A., Luna-Arias J.P., de Dios-Bravo M.G.,
RA   Herrera-Aguirre M.E., Olivares-Trejo J.J., Orozco E., Hernandez J.M.;
RT   "Entamoeba histolytica: a unicellular organism containing two active genes
RT   encoding for members of the TBP family.";
RL   Protein Expr. Purif. 70:48-59(2010).
CC   -!- FUNCTION: General transcription factor that functions at the core of
CC       the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA
CC       box is the initial transcriptional step of the pre-initiation complex
CC       (PIC), playing a role in the activation of eukaryotic genes transcribed
CC       by RNA polymerase II. {ECO:0000269|PubMed:20026212}.
CC   -!- SUBUNIT: Belongs to the TFIID complex together with the TBP-associated
CC       factors (TAFs). Binds DNA as monomer.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; Z48307; CAA88304.1; -; Genomic_DNA.
DR   EMBL; DS571521; EDS88986.1; -; Genomic_DNA.
DR   RefSeq; XP_001914239.1; XM_001914204.1.
DR   AlphaFoldDB; P52653; -.
DR   SMR; P52653; -.
DR   STRING; 5759.rna_EHI_020610-1; -.
DR   GeneID; 6220268; -.
DR   KEGG; ehi:EHI_020610; -.
DR   VEuPathDB; AmoebaDB:EHI5A_043810; -.
DR   VEuPathDB; AmoebaDB:EHI7A_023660; -.
DR   VEuPathDB; AmoebaDB:EHI8A_114190; -.
DR   VEuPathDB; AmoebaDB:EHI_020610; -.
DR   VEuPathDB; AmoebaDB:KM1_049680; -.
DR   eggNOG; KOG3302; Eukaryota.
DR   InParanoid; P52653; -.
DR   OMA; FHFKIAD; -.
DR   Proteomes; UP000001926; Partially assembled WGS sequence.
DR   GO; GO:0005669; C:transcription factor TFIID complex; IC:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   GO; GO:0060261; P:positive regulation of transcription initiation from RNA polymerase II promoter; IDA:UniProtKB.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IDA:UniProtKB.
DR   CDD; cd04516; TBP_eukaryotes; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   InterPro; IPR033710; TBP_eukaryotic.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..234
FT                   /note="TATA-box-binding protein 1"
FT                   /id="PRO_0000153972"
FT   REPEAT          52..136
FT                   /note="1"
FT   REPEAT          142..223
FT                   /note="2"
SQ   SEQUENCE   234 AA;  25967 MW;  FD2EFF20C1DBCB30 CRC64;
     MSTPGDFSLS PFILGGAVDP RSMSQLGNIC HADYMSTSTE SQERSLNNPN DTHPEIVNVV
     STFQLGVKLE LRKIVQKARN AEYNPKRFAG AIMRISSPKS TALIFQTGKI VCTGTRSIEE
     SKIASKKYAK IIKKIGYPIH YSNFNVQNIV GSCDVKFQIA LRTLVDSYLA FCQYEPEVFP
     GLVYRMASPK VTLLVFSTGK VVLTGAKDEE SLNLAYKNIY PILLANRKED ISNQ
 
 
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