TBP1_ORYSJ
ID TBP1_ORYSJ Reviewed; 633 AA.
AC Q9LL45; Q6K9S3; Q6K9S4;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Telomere-binding protein 1;
DE AltName: Full=Protein RTBP1;
GN Name=TBP1; OrderedLocusNames=Os02g0817800, LOC_Os02g57270;
GN ORFNames=OJ1136_C12.18-1, OJ1136_C12.18-2, OJ1202_E07.1-1, OJ1202_E07.1-2;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, HOMODIMERIZATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=10811811; DOI=10.1074/jbc.m003250200;
RA Yu E.Y., Kim S.E., Kim J.H., Ko J.H., Cho M.H., Chung I.K.;
RT "Sequence-specific DNA recognition by the Myb-like domain of plant
RT telomeric protein RTBP1.";
RL J. Biol. Chem. 275:24208-24214(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17586654; DOI=10.1105/tpc.107.051953;
RA Hong J.-P., Byun M.Y., Koo D.-H., An K., Bang J.-W., Chung I.K., An G.,
RA Kim W.T.;
RT "Suppression of RICE TELOMERE BINDING PROTEIN 1 results in severe and
RT gradual developmental defects accompanied by genome instability in rice.";
RL Plant Cell 19:1770-1781(2007).
RN [6]
RP STRUCTURE BY NMR OF 506-615, AND REGION.
RX PubMed=19152316; DOI=10.1021/bi801270g;
RA Ko S., Yu E.Y., Shin J., Yoo H.H., Tanaka T., Kim W.T., Cho H.-S., Lee W.,
RA Chung I.K.;
RT "Solution structure of the DNA binding domain of rice telomere binding
RT protein RTBP1.";
RL Biochemistry 48:827-838(2009).
CC -!- FUNCTION: Binds the telomeric double-stranded 5'TTTAGGG-3' repeat and
CC regulates telomere length and structure. {ECO:0000269|PubMed:10811811,
CC ECO:0000269|PubMed:17586654}.
CC -!- SUBUNIT: Homodimer.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10811811}.
CC -!- DISRUPTION PHENOTYPE: Severe developmental abnormalities of vegetative
CC organs and impaired reproductive organ formation. Chromosomal fusion in
CC mother pollen cells. Increased telomere length and frequency of
CC anaphase bridges containing telomeric repeat DNA.
CC {ECO:0000269|PubMed:17586654}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD21526.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAD21527.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAD22954.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAD22955.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAF10438.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF242298; AAF97508.1; -; mRNA.
DR EMBL; AP004028; BAD21526.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP004028; BAD21527.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP004048; BAD22954.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP004048; BAD22955.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008208; BAF10438.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015625433.1; XM_015769947.1.
DR RefSeq; XP_015625434.1; XM_015769948.1.
DR PDB; 2ROH; NMR; -; A=506-615.
DR PDBsum; 2ROH; -.
DR AlphaFoldDB; Q9LL45; -.
DR BMRB; Q9LL45; -.
DR SMR; Q9LL45; -.
DR STRING; 4530.OS02T0817800-02; -.
DR PaxDb; Q9LL45; -.
DR PRIDE; Q9LL45; -.
DR EnsemblPlants; Os02t0817800-03; Os02t0817800-03; Os02g0817800.
DR GeneID; 4331151; -.
DR Gramene; Os02t0817800-03; Os02t0817800-03; Os02g0817800.
DR KEGG; osa:4331151; -.
DR eggNOG; ENOG502QPSZ; Eukaryota.
DR HOGENOM; CLU_768125_0_0_1; -.
DR InParanoid; Q9LL45; -.
DR OrthoDB; 302274at2759; -.
DR EvolutionaryTrace; Q9LL45; -.
DR Proteomes; UP000000763; Chromosome 2.
DR Proteomes; UP000059680; Chromosome 2.
DR ExpressionAtlas; Q9LL45; baseline and differential.
DR Genevisible; Q9LL45; OS.
DR GO; GO:0000781; C:chromosome, telomeric region; IC:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR GO; GO:0042162; F:telomeric DNA binding; IDA:UniProtKB.
DR GO; GO:0032204; P:regulation of telomere maintenance; IMP:UniProtKB.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR031105; TRP_plant.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR21717; PTHR21717; 2.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chromosome; DNA-binding; Reference proteome; Telomere.
FT CHAIN 1..633
FT /note="Telomere-binding protein 1"
FT /id="PRO_0000387498"
FT DOMAIN 351..430
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT DOMAIN 529..588
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN ?534..?584
FT /note="SANT"
FT DNA_BIND 557..584
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 253..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 506..615
FT /note="Sufficient for telomeric DNA binding"
FT CONFLICT 416
FT /note="C -> Y (in Ref. 1; AAF97508)"
FT /evidence="ECO:0000305"
FT HELIX 539..552
FT /evidence="ECO:0007829|PDB:2ROH"
FT STRAND 553..555
FT /evidence="ECO:0007829|PDB:2ROH"
FT HELIX 557..565
FT /evidence="ECO:0007829|PDB:2ROH"
FT STRAND 566..568
FT /evidence="ECO:0007829|PDB:2ROH"
FT HELIX 573..588
FT /evidence="ECO:0007829|PDB:2ROH"
FT TURN 591..593
FT /evidence="ECO:0007829|PDB:2ROH"
FT HELIX 601..615
FT /evidence="ECO:0007829|PDB:2ROH"
SQ SEQUENCE 633 AA; 69509 MW; 93494F3C67BD30E4 CRC64;
MVLQKRLDYG SHGHRAPIKP RVATLAPVKR STRIRKKQMY ALDLLATAAE KLLADQDNLS
SGPNINETPE GYVTSMKPVK AEQFDEAFPL RSVAVKKDDC KGCTVGCAGI CGFLRQANMC
LAENSSTQNL ADSVLESLTA KPDVLAKDSF VSSKKSCRLG FGLGTIPEYG SVGVCQPWST
RSAEVKQVHR ARPTAIRSQE DSDAAALCAL VETMDLDTKP LAEASSGSNS GVHICGPDRG
HNSHPSCLAK VQHAADRDDD ENSSGCVHPS TSGNNRGYIP HYIGDRRIRR LFASRLRKAA
RNRICGEMSC KGNKLSLCEK KMPTTRRRVQ QTTLKRKRLA QLYSEKSSDE VKLTIKSFNI
PELLIEIPEN ATVGSLKKTV SDAVTTIIER GLRVGILLQG KNIQNDNKTL RQAGICRGKK
LNDIGFTLEC EAGQDSHPGV IVPEEMDFVG ASVVDKSATV KCEEPAENQQ LMQDFPGCSL
SDPGSVDYPV EWSTQETSAS SQAIVPFADP NSLALANVPL SRSKRPDFGQ RRIRRPFTVA
EVELLVEAVE HLGTGRWRDV KFRAFENVHH RTYVDLKDKW KTLVHTASIA PQQRRGAPVP
QELLDRVLAA QAYWSEQQAK LHGDPPVPEI CPT
