ID   TBP2_HALVD              Reviewed;         186 AA.
AC   D4H071;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=TATA-box-binding protein 2;
DE   AltName: Full=Box A-binding protein 2;
DE            Short=BAP 2;
DE   AltName: Full=TATA sequence-binding protein 2;
DE            Short=TBP 2;
DE   AltName: Full=TATA-box factor 2;
GN   Name=tbp2; OrderedLocusNames=HVO_1727;
OS   Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 /
OS   NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC   Haloferacaceae; Haloferax.
OX   NCBI_TaxID=309800;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM
RC   B-1768 / DS2;
RX   PubMed=20333302; DOI=10.1371/journal.pone.0009605;
RA   Hartman A.L., Norais C., Badger J.H., Delmas S., Haldenby S., Madupu R.,
RA   Robinson J., Khouri H., Ren Q., Lowe T.M., Maupin-Furlow J.,
RA   Pohlschroder M., Daniels C., Pfeiffer F., Allers T., Eisen J.A.;
RT   "The complete genome sequence of Haloferax volcanii DS2, a model
RT   archaeon.";
RL   PLoS ONE 5:E9605-E9605(2010).
RN   [2]
RP   SAMPYLATION AT LYS-53 AND LYS-63, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=20054389; DOI=10.1038/nature08659;
RA   Humbard M.A., Miranda H.V., Lim J.M., Krause D.J., Pritz J.R., Zhou G.,
RA   Chen S., Wells L., Maupin-Furlow J.A.;
RT   "Ubiquitin-like small archaeal modifier proteins (SAMPs) in Haloferax
RT   volcanii.";
RL   Nature 463:54-60(2010).
CC   -!- FUNCTION: General factor that plays a role in the activation of
CC       archaeal genes transcribed by RNA polymerase. Binds specifically to the
CC       TATA box promoter element which lies close to the position of
CC       transcription initiation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000305}.
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DR   EMBL; CP001956; ADE04912.1; -; Genomic_DNA.
DR   RefSeq; WP_004041616.1; NZ_AOHU01000030.1.
DR   AlphaFoldDB; D4H071; -.
DR   SMR; D4H071; -.
DR   STRING; 309800.C498_03989; -.
DR   PRIDE; D4H071; -.
DR   EnsemblBacteria; ADE04912; ADE04912; HVO_1727.
DR   GeneID; 8924973; -.
DR   KEGG; hvo:HVO_1727; -.
DR   eggNOG; arCOG01764; Archaea.
DR   HOGENOM; CLU_060161_4_3_2; -.
DR   OMA; VYRMDEP; -.
DR   OrthoDB; 83880at2157; -.
DR   Proteomes; UP000008243; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   CDD; cd04518; TBP_archaea; 1.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR033711; TBP_archaea.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Isopeptide bond; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Ubl conjugation.
FT   CHAIN           1..186
FT                   /note="TATA-box-binding protein 2"
FT                   /id="PRO_0000397111"
FT   REPEAT          10..86
FT                   /note="1"
FT   REPEAT          101..179
FT                   /note="2"
FT   CROSSLNK        53
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SAMP2)"
FT   CROSSLNK        63
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SAMP2)"
SQ   SEQUENCE   186 AA;  19882 MW;  2C41752D0C3FAEB0 CRC64;
     MSGPADSIEI QNVVASTGIG QELDLEALAD DLPGADFNPD NFPGLVYRTQ DPKAAALIFR
     SGKIVCTGAK SIDDVHDALG IIFDKLRELK IPVDDEPEIT VQNIVSSADL GHNLNLNALA
     IGLGLEDVEY EPEQFPGLVY RMDEPKVVIL LFGSGKIVIT GGKRTDDAET AVEEIVERID
     ALGLLG