ID   TBP2_METAC              Reviewed;         185 AA.
AC   Q8TU94;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=TATA-box-binding protein 2 {ECO:0000255|HAMAP-Rule:MF_00408};
DE   AltName: Full=Box A-binding protein 2 {ECO:0000255|HAMAP-Rule:MF_00408};
DE            Short=BAP 2 {ECO:0000255|HAMAP-Rule:MF_00408};
DE   AltName: Full=TATA sequence-binding protein 2 {ECO:0000255|HAMAP-Rule:MF_00408};
DE            Short=TBP 2 {ECO:0000255|HAMAP-Rule:MF_00408};
DE   AltName: Full=TATA-box factor 2 {ECO:0000255|HAMAP-Rule:MF_00408};
GN   Name=tbp2 {ECO:0000255|HAMAP-Rule:MF_00408}; Synonyms=tbp-2;
GN   OrderedLocusNames=MA_0179;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
CC   -!- FUNCTION: General factor that plays a role in the activation of
CC       archaeal genes transcribed by RNA polymerase. Binds specifically to the
CC       TATA box promoter element which lies close to the position of
CC       transcription initiation. {ECO:0000255|HAMAP-Rule:MF_00408}.
CC   -!- SIMILARITY: Belongs to the TBP family. {ECO:0000255|HAMAP-
CC       Rule:MF_00408}.
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DR   EMBL; AE010299; AAM03632.1; -; Genomic_DNA.
DR   RefSeq; WP_011020237.1; NC_003552.1.
DR   AlphaFoldDB; Q8TU94; -.
DR   SMR; Q8TU94; -.
DR   STRING; 188937.MA_0179; -.
DR   EnsemblBacteria; AAM03632; AAM03632; MA_0179.
DR   GeneID; 1472071; -.
DR   KEGG; mac:MA_0179; -.
DR   HOGENOM; CLU_060161_4_3_2; -.
DR   InParanoid; Q8TU94; -.
DR   OMA; ITGCEVR; -.
DR   OrthoDB; 83880at2157; -.
DR   PhylomeDB; Q8TU94; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0140223; F:general transcription initiation factor activity; IBA:GO_Central.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IBA:GO_Central.
DR   Gene3D; 3.30.310.10; -; 2.
DR   HAMAP; MF_00408; TATA_bind_prot_arch; 1.
DR   InterPro; IPR000814; TBP.
DR   InterPro; IPR030491; TBP_CS.
DR   InterPro; IPR012295; TBP_dom_sf.
DR   PANTHER; PTHR10126; PTHR10126; 1.
DR   Pfam; PF00352; TBP; 2.
DR   PRINTS; PR00686; TIFACTORIID.
DR   PROSITE; PS00351; TFIID; 2.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..185
FT                   /note="TATA-box-binding protein 2"
FT                   /id="PRO_0000154006"
FT   REPEAT          7..84
FT                   /note="1"
FT   REPEAT          100..178
FT                   /note="2"
SQ   SEQUENCE   185 AA;  20347 MW;  4A7B2F0B7DF9655A CRC64;
     MEPTITIENI VASTRLAEDF DLQKLLDTGL KGAVYNKNKF PGLVYRIENP KAAFLIFASG
     KVVCTGTKNV ENSRIALFNL ANELNSIGYK GIYLKPEIHV QNVVASANLR TSLNLNAVLS
     AFGVENVEYE PEVFPGLVYK LADPRVVVLV FRTGKLVITG GKCPEDCEEG LRIIKTQLDN
     LGLLY